Nilofer Qureshi, Ph.D.
Professor, Director - Molecular and Cellular Immunology
Department(s) of Biomedical Sciences
UMKC School of Medicine
Education and Background
Physiological Chemistry - University of Wisconsin
Meet Nilofer Qureshi
Specialties and Research/Medical Interests
To develop novel therapeutic approaches to treat septic shock and inflammation.
We were the first to establish the complete structure of the lipid A moiety of the enterobacterial lipopolysaccharide (LPS), developed monophosphoryl lipid A as an effective adjuvant and Rhodobacter sphaeroides diphosphoryl lipid A as a powerful LPS antagonist in both in vitro and in vivo systems. Our recent research centers on the biology of LPS, especially, with regards to its effect on the ubiquitin-proteasome pathway (UPP) in macrophages and septic shock. We initially demonstrated that the LPS-induced cytokines are dependent on the composition of proteasome’s subunits present in the macrophages. We are working on a novel therapeutic approach for septic shock based upon proteasome inhibitors and antibiotics. We are also establishing the identity of ubiquitinated proteins in the LPS-induced signal transduction that are degraded by the proteasome in murine macrophages and human cells. Our conclusion from these studies is that the proteasome is a central regulator of macrophage function and inflammation and is involved in several diseases such as septic shock, cardiovascular problems, cancer and asthma.
Qureshi N, Perera P-Y, Shen J, Zhang G, Lenschat A, Spptter G, Morrison DC, Vogel SN. The proteasome as a LPS-binding protein in macrophages: Differential effects of proteasome inhibition on LPS-induced events. J Immunol. 2003, 171:1515-1525.
Qureshi N, Vogel SN, Van Way III, Papasian C, Qureshi AA, Morrison DC. The proteasome, a central regulator of Inflammation and macrophage function. Immunologic Research 2005, 31/3:243-260.
Shen J, Reis J, Morrison DC, Papasian C, Sreekumar R, Kolbert C, Qureshi AA, Vogel SN and Qureshi N: Key Inflammatory signapng pathways are regulated by the proteasome. Shock 2006, 25:472-484.
Reis J, Guan X-Q, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, Van Way C III, Vogel SN, and Qureshi N. LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochemistry and Biophysics (in press 2010).
Reis J, Hassan F, Guan X-Q, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way C III, Vogel SN, Morrison DC, and Qureshi N. LMP Subunits of the proteasomes regulate the TRIF/TRAM pathway. Cell Biochemistry and Biophysics (in press 2010).