Research

Research Topics & Faculty – JR Faculty

The School of Medicine is focused on advancing excellence in health outcomes, informatics, patient safety and community health, and it actively supports research in these areas. Through its esteemed faculty, exceptional students and residents, and more than 20 endowed chairs leading research efforts, UMKC School of Medicine is leading a successful effort to build biomedical research programs that are responsive to medical conditions in our community.

Anesthesiology, Surgery, Orthopaedic Surgery

Orthopaedics

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Affiliated Faculty

Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital
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Research Interests

I am willing to tailor projects to meet the needs of students; however, they should be in my discipline of Pediatric or Adult Physical Medicine and Rehabilitation. Some unique areas of interest are: Cerebral palsy Clinical pharmacology Spasticity management Adaptive sports Disability populations Concussion Traumatic brain or spinal cord injury.


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Gary Sutkin, M.D., M.B.A.
Gary Sutkin, M.D., M.B.A.
Professor and Program Director Associate Dean of Women’s HealthVictor and Caroline Schutte Chair in Women’s Health

Professor, Department of Biomedical and Health Informatics (Tenure) and Obstetrics and Gynecology

  • M.D. Degree: Northwestern University
  • M.B.A. Degree: J.L. Kellogg Graduate School of Management
  • Residency: Magee Womens Hospital, Pittsburgh, PA
  • Fellowship: Magee Womens Hospital, Pittsburgh, PA
  • Certification: American Board of Obstetricians and Gynecologists, Subspecialty Female Pelvic Medicine and Reconstructive Surgery
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Biography

Gary Sutkin is the Associate Dean and Victor and Caroline Schutte Chair in Women’s Health. He is a Professor with tenure in the Department of Obstetrics and Gynecology and the Department of Biomedical and Health Informatics.

Dr. Sutkin comes to the University of Missouri Kansas City from the University of Pittsburgh. There he was in the Academy of Master Educators and directed the Obstetrics and Gynecology core clerkship. His research centered on surgical education and the prevention of postoperative urinary tract infections. He was a co-investigator in the NIH Pelvic Floor Disease Network. He contributed to the establishment of the Nazarbayev School of Medicine in Astana Kazakhstan.

Dr. Sutkin’s research interests center on surgical safety and error prevention. He is interested in how communication between attending and resident surgeons impact patient outcome. He collaborates with a cognitive psychologist and members of the Department of Civil and Mechanical Engineering.

He is a practicing Urogynecologist and specializes in women with pelvic floor prolapse. He provides both reconstructive pelvic surgery and non-surgical treatments for women with pelvic organ prolapse, urinary incontinence, and other pelvic floor disorders.

Dr. Sutkin was born in San Antonio and grew up in Richardson, Texas. He attended Northwestern University’s Honors Program in Medical Education, worked at the federal Reserve bank in Chicago, and attained his BS, MD, and MBA degrees at Northwestern. He is an avid Northwestern fan.

Awards
  • Association of Professors of Gynecology and Obstetrics Teaching Award – 2002
  • Association of Professors of Gynecology and Obstetrics/Solvay Scholar – 2002-2003
  • Alpha Omega Alpha Society – 2003
  • Texas Tech University Health Sciences Center Dean’s Clinical Science Teaching Award – 2006
  • Council on Resident Education in Obstetrics and Gynecology Teaching Award – 2011
  • Residency Program Top 10% Golden Apple Teaching Award – 2011
  • Appointment to University of Pittsburgh School of Medicine Academy of Master Educators – 2012
  • Finalist, Patil Teaching Innovation Award – 2015
Research Interests
  • Surgical error prevention and communication
  • Intraoperative teaching
  • Midurethral sling surgery
  • Postoperative Urinary tract infections
Selected Publications
  1. Sutkin G, Littleton E, Kanter S. Intelligent cooperation: A framework of pedagogic practice in the operating room. Am J Surg. 2017 Publication Pending
  2. Oliphant S, Littleton E, Gosman G, Sutkin, G. Teaching the Retropubic Midurethral Sling  Using a Novel Cadaver and Model-Based Approach. Cureus. 2017; 9(5): e1214. DOI 10.7759/cureus.1214. PMID:PMC5453826.
  3. Paradis E, Sutkin G. Beyond a Good Story: From Hawthorne Effect to Reactivity in Health Professions Education Research. Medical Education. 2016 PMID: 27580703.
  4. Markland AD, Jelovsek E, Whitehead WE, Andy UU, Newman DK, Dyer K, Harm-Ernandes I, Cichowski S, McCormick J, Rardin C, Sutkin G, Shaffer A, Meikle S. Implementation of a Multi-site Manometric Biofeedback Intervention with Anorectal Manometry for the Treatment of Fecal Incontinence in Women. Neurogastroenterology and Motility. 2016 PMID: 27453154.
  5. Lowder J, Oliphant S, Shepherd J, Ghetti C, Sutkin G. Genital Hiatus Size is Associated with and Predictive of Apical Vaginal Support Loss. Am J Obstetrics Gynecology. 2015; PMID: 26719211
  6. J. Eric Jelovsek, Alayne D. Markland , William E. Whitehead, Matthew D. Barbe, Diane K. Newman, Rebecca G. Rogers, Keisha Dyer, Anthony Visco, Vivian W. Sung MD, Sutkin G, Susan F. Meikle Marie G. Gantz. Controlling anal incontinence by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods. Contemp Clin Trials. 2015;44, 164-74. PMID: 26291917
  7. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 2: Physical teaching guidance. Journal of Surgical Education. 2015; 72(2), 251-7. PMID: 25468768
  8. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 1: Verbal teaching guidance. Journal of Surgical Education. 2015;72(2), 243-50. PMID: 25456208
  9. Zimmern P, Litman HJ, Nager CW, Lemack GE, Richter HE, Sirls L, Kraus SR, Sutkin G, Mueller ER. Effect of aging on storage and voiding function in women with stress-predominant urinary incontinence. J Urol. 2014 Feb 8. pii: S0022-5347(14)00131-1. doi: 10.1016/j.juro.2014.01.092. PMID: 24518790.
  10. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013;2013:926313.  doi: 10.1155/2013/926313. Epub 2013 Sep 8. PMID: 24194763; PMCID: PMC3782123.
  11. Sutkin G, Dzialowski K. A gynaecologic clinic dedicated to student teaching. Clin Teach. 2013 Jun;10(3):181-5. doi: 10.1111/j.1743-498X.2012.00633.x. PMID: 23656681
  12. Nager CW, Brubaker L, Litman HJ, Zyczynski HM, Varner RE, Amundsen C, Sirls LT, Norton PA, Arisco AM, Chai TC, Zimmern P, Barber MD, Dandreo KJ, Menefee SA, Kenton K, Lowder J, Richter HE, Khandwala S, Nygaard I, Kraus SR, Johnson HW, Lemack GE, Mihova M, Albo ME, Mueller E, Sutkin G, Wilson TS, Hsu Y, Rozanski TA, Rickey LM, Rahn D, Tennstedt S, Kusek JW, Gormley EA; Urinary Incontinence Treatment Network. A randomized trial of urodynamic testing before stress-incontinence surgery. N Engl J Med. 2012 May 24;366(21):1987-97. doi: 10.1056/NEJMoa1113595. Epub 2012 May 2. PMID: 22551104; PMCID: PMC3386296
  13. Skoczylas LC, Littleton EB, Kanter SL, Sutkin G. Teaching techniques in the operating room: the importance of perceptual motor teaching. Acad Med. 2012 Mar;87(3):364-71. doi: 10.1097/ACM.0b013e31824484a0. PMID: 22373633.
  14. Nygaard I, Brubaker L, Chai TC, Markland AD, Menefee SA, Sirls L, Sutkin G, Zimmern P, Arisco A, Huang L, Tennstedt S, Stoddard A. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011 Oct;22(10):1255-65. doi: 10.1007/s00192-011-1429-9. Epub 2011 May 11.  PMID: 21560012.
  15. Martirosian Smith TE, Trowbridge ER, Pastore LM, Smith SC, Brennan MC, Dooley Y, Matthews CK, Ozel B, Sutkin G, Hullfish KL. Multicenter Urogynecology Study on Education: Medical Student Educational Experiences and Knowledge Outcomes During the OBGYN Clerkship. Female Pelvic Med Reconstr Surg. 2011 Mar;17(2):100-104. PMID: 22453697.
  16. Sutkin G, Daucher J, Zyczynski H. Prolapse in the Older Woman. European Urologic Review. 2010;5:64-8.
  17. Park AJ, Barber MD, Bent AE, Dooley YT, Dancz C, Sutkin G, Jelovsek JE. Assessment of intraoperative judgment during gynecologic surgery using the Script Concordance Test. Am J Obstet Gynecol. 2010 Sep;203(3):240.e1-6. doi: 10.1016/j.ajog.2010.04.010. Epub 2010 May 21. PMID: 20494330.
  18. Nager CW, Kraus SR, Kenton K, Sirls L, Chai TC, Wai C, Sutkin G, Leng W, Litman H, Huang L, Tennstedt S, Richter HE; Urinary Incontinence Treatment Network. Urodynamics, the supine empty bladder stress test, and incontinence severity. Neurourol Urodyn. 2010 Sep;29(7):1306-11. doi: 10.1002/nau.20836. PMID: 20127832.
  19. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug;21(8):955-61. doi: 10.1007/s00192-010-1137-x. Epub 2010 Mar 31. PMID: 20354678.
  20. Sutkin G, Littlefield JH, Laube DW. Nursing staff assessment of residents’ professionalism and communication skills. Med Educ. 2009 Nov;43(11):1104. doi: 10.1111/j.1365-2923.2009.03461.x. Epub 2009 Oct 2. PMID: 19799729.
  21. Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CISC) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Aug;20(8):933-8. doi: 10.1007/s00192-009-0885-y. Epub 2009 Apr 10. PMID: 19582384.
  22. Sutkin G, Aronoff CK. Resident front office experience: a systems-based practice activity. Med Educ Online. 2008 May 28;13:6. doi: 10.3885/meo.2008.T0000120. PMID: 20165536; PMCID: PMC2779599.
  23. Sutkin G, Wagner E, Harris I, Schiffer R. What makes a good clinical teacher in medicine? A review of the literature. Acad Med. 2008 May;83(5):452-66. doi: 10.1097/ACM.0b013e31816bee61. Review. PMID: 18448899.
  24. Sutkin G, Burley H, Zhang K, Arora N. Characteristics of good clinical educators from medical students perspectives: A Qualitative inquiry using a web-based survey system. International Journal of Healthcare Information Systems and Informatics. 2008;3(2):69-86.
  25. Sutkin G, Krohn MA, Heine RP, Sweet RL. Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. Obstet Gynecol. 2005 Mar;105(3):581-6. PMID: 15738028.
  26. Sutkin G, Mamlok V. Images in clinical medicine. Fetus papyraceus. N Engl J Med. 2004 Apr 15;350(16):1665. PMID: 15084699.

Complete list of publications

Biochemistry & Cell Biology

Biochemistry

Affiliated Faculty

Photo of Charles S. Barnes, Ph.D.
Charles S. Barnes, Ph.D.
Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Our research is in Allergy, Asthma snd Immunology. We research the nature and disposition of allergic proteins in the environment. We have identified proteins to which people are allergic. We have developed assays for these proteins.We study where these proteins are in the environment. And we do research in controlling the exposure to these proteins.


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
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Research Interests

Investigate the roles and molecular mechanisms of nicotinamide phosphoribosyltransferase in acute respiratory distress syndrome, arthritis, drug induced liver injury.

Identify new genetic risk factors underlying complex diseases using next generation DNA sequencing technologies.

Apply Translational Bioinformatics to leverage ‘Big Data’ to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.


Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Dr. Sampath, a physician-scientist in Neonatology, is passionate about understanding the why and how behind babies developing severe lung (BPD) and intestinal (NEC) disease using his expertise in innate immune signaling. Laboratory members study various aspects of neonatal lung disease (BPD) and bowel disease (NEC) using a team science approach. We use complementary approaches involving transgenic mice, cell-culture experiments and human genetics to identify the mechanisms regulating development of these diseases. We hope that our research will provide novel insights into BPD and NEC pathogenesis in neonates that will translate to better options for disease diagnosis and treatment. Current projects include: 1. Regulation of lung endothelial inflammation in the developing lung, 2. Mechanisms underlying impaired vascular development in BPD, 3. Role of TRIP-1 role in lung injury and repair. 4. Animal models to dissect the role of aberrant innate immune signaling in NEC, 5. Genomic susceptibility of NEC and sepsis phenotypes in newborn babies, 6. Effect of sepsis on lung TGFβ signaling and abnormal lung development.


Photo of Michael Wacker, Ph.D.
Michael Wacker, Ph.D.
Assistant Dean of Medical Student Research Associate Teaching Professor, Vice-chair Biomedical SciencePhysiology, Biomedical Sciences Work Phone: (816) 235-6069
  • University of Kansas – Ph.D. (2003)
  • Texas Christian University – B.S. (1997)
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Biography

Dr. Wacker joined the Department of Basic Medical Science in the School of Medicine in 2007. He currently teaches physiology in the Human Structure Function series taught to the medical school students, as well as physiology courses in the Anesthesiologist Assistant program and the Physician Assistant program. Dr. Wacker is a member of the Muscle Biology Group at UMKC with expertise in cardiac muscle physiology. The interests in his laboratory focus on agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. Acutely, changes in calcium homeostasis can lead to arrhythmias and alteration of cardiac muscle contractility. More chronic alterations in calcium, however, can lead to remodeling of the heart as observed in cardiac hypertrophy and heart failure. Specifically, Dr. Wacker is interested in endocrine/paracrine agents which may directly alter calcium changes in cardiac myocytes via signaling mediated by membrane receptors. Recently, Dr. Wacker and the Muscle Biology Group have worked in collaboration with the UMKC Bone Biology Group on a NIH-funded project exploring mechanisms of bone-muscle crosstalk. Dr. Wacker’s laboratory has concentrated on a hormone, FGF23, released by bone cells that may play a role in directly altering cardiac function during chronic kidney disease. Additional interests in the laboratory focus on how thromboxane A2, intracellular phosphoinositide signaling, and fibrate drugs may directly alter cardiac muscle function.

Research Interests

My laboratory is interested in agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. I am specifically interested in endocrine/paracrine agents which may directly alter cardiac function. One main area of focus currently in the lab is on hormones/toxins (e.g. FGF23) that are elevated during chronic kidney disease that may cause heart disease. Typical experiments in the lab center around measuring cardiac contractility/ function, Langendorf perfusion of isolated hearts, calcium imaging of cardiac myocytes, cardiac gene/protein changes, exploring cardiac myocyte signal transduction mechanisms like IP3 signaling, and blood vessel function.

 

Recent Publications

Gallagher PM, Touchberry CD, Teson K, McCabe E, Tehel M, Wacker MJ. Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression. Applied Physiology, Nutrition, and Metabolism. 38 (5): 581-586, 2013. PMID: 23668768

Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, Girgis M, Vincent RJ, Wetmore LA, Dawn B, Bonewald L, Stubbs JR, Wacker MJ. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. American Journal of Physiology: Endocrinology and Metabolism. 304 (8): E863-873. 2013. PMID: 23443925

Bonewald LF, Wacker MJ. FGF23 Production by Osteocytes. Pediatric Nephrology. 28 (4): 563-568. 2013. PMID: 22983423

Silswal N, Parelkar NK, Wacker MJ, Badr M, Andresen J.   PPARa-Independent Arterial Smooth Muscle Relaxant Effects of PPARa Agonists. PPAR Research. 302495. 2012. PMID: 23008696

Wacker MJ, Tevis O, Hanke J, Howard T, Gilbert W, Orr JA. Characterization of thromboxane A2 receptor and TRPV1 mRNA in cultured sensory neurons. Neuroscience Letters. 515(1):12-7. 2012. PMID: 22425716

Silswal N, Parelkar N, Wacker MJ, Brotto M, Andresen J. Phosphatidylinositol 3,5-bisphosphate increases intracellular free calcium in arterial smooth muscle cells and elicits vasocontraction. American Journal of Physiology: Heart and Circulatory Physiology. 300 (6): H2016-26. 2011. PMID: 21421826

Touchberry CD, Elmore CJ, Nguyen TM, Andresen JJ, Zhao X, Orange M, Weisleder N, Brotto M, Claycomb WC, Wacker MJ. Store-Operated Calcium Entry is Present in HL-1 Cardiomyocytes and Contributes to Resting Calcium. Biochemical and Biophysical Research Communications. 416 (1-2): 45-50. 2011. PMID: 22079292

Touchberry CD, Bales IK, Stone JK, Rohrberg TJ, Parelkar NK, Nguyen T, Fuentes O, Liu X, Qu CK, Andresen JJ, Valdivia HH, Brotto M, Wacker MJ. Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility Via Activation of the Ryanodine Receptor. Journal of Biological Chemistry. 285 (51): 40312-21. 2010. PMID: 20947503

Biomedical & Health Informatics

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Biomedical and Health Informatics

Affiliated Faculty

Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
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Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

CDC funded use of laboratory and medical data warehouses to support quality improvement.

Pharmacogenomic knowledge representation and decision support.

Influence of patient context on health, what I refer to as the ‘Envirome’.

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Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital
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Research Interests

I am willing to tailor projects to meet the needs of students; however, they should be in my discipline of Pediatric or Adult Physical Medicine and Rehabilitation. Some unique areas of interest are: Cerebral palsy Clinical pharmacology Spasticity management Adaptive sports Disability populations Concussion Traumatic brain or spinal cord injury.


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

I lead multiple research projects in the areas of Autism Spectrum Disorders and Developmental Disabilities: One series of projects is focused on autism and developmental screening in primary care medical settings. We have an ongoing quality improvement initiate at Children’s Mercy, which has yielded a large health database. We have use this database for additional projects related to health disparities and health outcomes related to screening. I am interested in research related to parenting and autism/developmental disabilities, health care access, health & treatment outcomes, dissemination, and the education and training of healthcare professionals about developmental disabilities. Finally, I am the site PI for a large epidemiological study on autism and developmental disabilities funded by the Centers for Disease Control.


Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
More Info

Research Interests

Investigate the roles and molecular mechanisms of nicotinamide phosphoribosyltransferase in acute respiratory distress syndrome, arthritis, drug induced liver injury.

Identify new genetic risk factors underlying complex diseases using next generation DNA sequencing technologies.

Apply Translational Bioinformatics to leverage ‘Big Data’ to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.


Photo of Steve Simon, Ph.D.
Steve Simon, Ph.D.
Research Professor Department of Biomedical & Health Informatics
  • 1982 -University of Iowa
  • Research interests: Accrual problems in clinical trials, information theory, monitoring adverse events in clinical trials, research ethics and risk adjustment models.
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Research Summary

Most of my research is characterized as meta-research–research about the research process. One example is monitoring accrual patterns in prospective clinical trials. Another is mining the electronic health records to identify patients for clinical trials. A third example is comparing the initial IRB research application to what (if anything) gets published.


Cardiology

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Cardiology

Affiliated Faculty
Photo of Michael Wacker, Ph.D.
Michael Wacker, Ph.D.
Assistant Dean of Medical Student Research Associate Teaching Professor, Vice-chair Biomedical SciencePhysiology, Biomedical Sciences Work Phone: (816) 235-6069
  • University of Kansas – Ph.D. (2003)
  • Texas Christian University – B.S. (1997)
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Biography

Dr. Wacker joined the Department of Basic Medical Science in the School of Medicine in 2007. He currently teaches physiology in the Human Structure Function series taught to the medical school students, as well as physiology courses in the Anesthesiologist Assistant program and the Physician Assistant program. Dr. Wacker is a member of the Muscle Biology Group at UMKC with expertise in cardiac muscle physiology. The interests in his laboratory focus on agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. Acutely, changes in calcium homeostasis can lead to arrhythmias and alteration of cardiac muscle contractility. More chronic alterations in calcium, however, can lead to remodeling of the heart as observed in cardiac hypertrophy and heart failure. Specifically, Dr. Wacker is interested in endocrine/paracrine agents which may directly alter calcium changes in cardiac myocytes via signaling mediated by membrane receptors. Recently, Dr. Wacker and the Muscle Biology Group have worked in collaboration with the UMKC Bone Biology Group on a NIH-funded project exploring mechanisms of bone-muscle crosstalk. Dr. Wacker’s laboratory has concentrated on a hormone, FGF23, released by bone cells that may play a role in directly altering cardiac function during chronic kidney disease. Additional interests in the laboratory focus on how thromboxane A2, intracellular phosphoinositide signaling, and fibrate drugs may directly alter cardiac muscle function.

Research Interests

My laboratory is interested in agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. I am specifically interested in endocrine/paracrine agents which may directly alter cardiac function. One main area of focus currently in the lab is on hormones/toxins (e.g. FGF23) that are elevated during chronic kidney disease that may cause heart disease. Typical experiments in the lab center around measuring cardiac contractility/ function, Langendorf perfusion of isolated hearts, calcium imaging of cardiac myocytes, cardiac gene/protein changes, exploring cardiac myocyte signal transduction mechanisms like IP3 signaling, and blood vessel function.

 

Recent Publications

Gallagher PM, Touchberry CD, Teson K, McCabe E, Tehel M, Wacker MJ. Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression. Applied Physiology, Nutrition, and Metabolism. 38 (5): 581-586, 2013. PMID: 23668768

Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, Girgis M, Vincent RJ, Wetmore LA, Dawn B, Bonewald L, Stubbs JR, Wacker MJ. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. American Journal of Physiology: Endocrinology and Metabolism. 304 (8): E863-873. 2013. PMID: 23443925

Bonewald LF, Wacker MJ. FGF23 Production by Osteocytes. Pediatric Nephrology. 28 (4): 563-568. 2013. PMID: 22983423

Silswal N, Parelkar NK, Wacker MJ, Badr M, Andresen J.   PPARa-Independent Arterial Smooth Muscle Relaxant Effects of PPARa Agonists. PPAR Research. 302495. 2012. PMID: 23008696

Wacker MJ, Tevis O, Hanke J, Howard T, Gilbert W, Orr JA. Characterization of thromboxane A2 receptor and TRPV1 mRNA in cultured sensory neurons. Neuroscience Letters. 515(1):12-7. 2012. PMID: 22425716

Silswal N, Parelkar N, Wacker MJ, Brotto M, Andresen J. Phosphatidylinositol 3,5-bisphosphate increases intracellular free calcium in arterial smooth muscle cells and elicits vasocontraction. American Journal of Physiology: Heart and Circulatory Physiology. 300 (6): H2016-26. 2011. PMID: 21421826

Touchberry CD, Elmore CJ, Nguyen TM, Andresen JJ, Zhao X, Orange M, Weisleder N, Brotto M, Claycomb WC, Wacker MJ. Store-Operated Calcium Entry is Present in HL-1 Cardiomyocytes and Contributes to Resting Calcium. Biochemical and Biophysical Research Communications. 416 (1-2): 45-50. 2011. PMID: 22079292

Touchberry CD, Bales IK, Stone JK, Rohrberg TJ, Parelkar NK, Nguyen T, Fuentes O, Liu X, Qu CK, Andresen JJ, Valdivia HH, Brotto M, Wacker MJ. Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility Via Activation of the Ryanodine Receptor. Journal of Biological Chemistry. 285 (51): 40312-21. 2010. PMID: 20947503

Community & Family Medicine

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Community and Family Medicine

Affiliated Faculty
Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

I lead multiple research projects in the areas of Autism Spectrum Disorders and Developmental Disabilities: One series of projects is focused on autism and developmental screening in primary care medical settings. We have an ongoing quality improvement initiate at Children’s Mercy, which has yielded a large health database. We have use this database for additional projects related to health disparities and health outcomes related to screening. I am interested in research related to parenting and autism/developmental disabilities, health care access, health & treatment outcomes, dissemination, and the education and training of healthcare professionals about developmental disabilities. Finally, I am the site PI for a large epidemiological study on autism and developmental disabilities funded by the Centers for Disease Control.

Emergency Medicine

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Emergency Medicine

Affiliated Faculty

Photo of P. Charles Inboriboon, M.D., FACEP
P. Charles Inboriboon, M.D., FACEP
Associate Professor – UMKC Truman Medical Center Hospital Hill; Childrens Mercy Kansas CityDepartment of Emergency Medicine
  • Dept Position:  Associate Residency Program Director
  • Undergraduate School:  University of Illinois at Chicago
  • Medical School:  University of Illinois at Chicago
  • EM Residency:  University of Illinois at Chicago
  • Fellowship:  University of Rochester (International Emergency Medicine)
  • ABEM Diplomate:  2007
  • MPH:  University of Rochester, 2010
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Biography

Dr. Inboriboon was born and raised in Chicago, IL. He completed the combined BS/MD program at the University of Illinois at Chicago. Subsequently, he completed his emergency medicine residency training at the University of Illinois at Chicago where he served as chief resident. Following residency he completed a fellowship in international emergency medicine and obtained his masters in public health at the University of Rochester. During that time, he worked abroad in Thailand, India, Haiti, Kosovo, and Nicaragua. Following completion of his fellowship he stayed on as teaching faculty until he relocated to San Diego, where his wife pursued her fellowship training in Rheumatology. In 2012, he joined the Department of Emergency Medicine at UMKC where he serves as Director of International Emergency Medicine Programs and as part of the Residency Leadership. He works clinically at both Truman Medical Center and Children’s Mercy Hospital. His academic interests include medical education and technology, international emergency medicine systems development, and global health.

Research Interests

Current projects include: Sepsis: Evaluation of patients that are discharged from the ED that presented with SIRS criteria. We are looking at factors associated with return visits and 30 day mortality. We are also looking at mechanisms related to sepsis and how they can be potentially be modified. Human Factors/Medical Education: We are looking at developing a residency dashboard that will facilitate medical education activities included required administrative tasks and development of an online educational repository. Health Disparities/Global health: Looking at health disparities in asthma management.


Photo of Emily A, Hillman, MD
Emily A, Hillman, MD
Assistant Professor, Medical Director Simulation, UMKC Clinical Training Facility Truman Medical CentersDepartment of Emergency Medicine
  • Dept Positions:  Assistant Program Director & Student Clerkship Director
  • Undergraduate School:  University of Missouri-Kansas City
  • Medical School:  University of Missouri-Kansas City
  • EM Residency:  University of Missouri-Kansas City, Truman Medical Center
  • ABEM Diplomate:  2012
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Biography

I was born and raised in Overland Park, Kansas. I am a graduate of the UMKC 6-year combined BA/MD program. I did my residency training at UMKC/Truman Medical center and graduated in 2011. I worked for a year in community emergency medicine and I enjoyed the experience but I missed being at an academic center. I realized how much I enjoyed resident and medical student education. I became a full time faculty member with our residency program in the summer of 2012.

I am currently the assistant program director and student clerkship director. I am actively involved with our student interest group. I enjoy simulation education and I am presently involved with simulation research. I enjoy spending time with my husband, our daughter, and our 2 cocker spaniels.

Research Interests

Emergency Department iPads for the EM clerkship- assessing whether implementation and use improved NBME exam performance. Working on data analysis.

Mixed methods study assessing paramedic-physician hand off communication. Working on qualitative data analysis.

Assessment of pain med prescribing habits of ED providers. Working on abstract revision.

Survey on high school students regarding their participation in a summer simulation educational experience. Working on abstract/manuscript.


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 

Genetics & Developmental Biology

Genetics

Affiliated Faculty

Jessica A. Hellings, M.B.B.Ch.
Professor, University of Missouri-Kansas City Center for Behavioral MedicinePsychiatry
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Research Interests

Psychopharmacology studies of old drugs in autism: Loxapine, amitriptyline, dextroamphetamine, BDNF Attachment in Developmental Disabilities ADHD in ASD/DD Psychological mindedness Gluten allergy, celiac disease and neuropsychiatric illness; gut-brain biology in neuropsychiatric illness.


Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education
  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials
Research Interests

Bilirubin neurotoxicity, kernicterus, neurodevelopmental disorders, auditory neurology, movement disorders, clinical neurophysiology.

For additional information, please click here.

 


Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Dr. Sampath, a physician-scientist in Neonatology, is passionate about understanding the why and how behind babies developing severe lung (BPD) and intestinal (NEC) disease using his expertise in innate immune signaling. Laboratory members study various aspects of neonatal lung disease (BPD) and bowel disease (NEC) using a team science approach. We use complementary approaches involving transgenic mice, cell-culture experiments and human genetics to identify the mechanisms regulating development of these diseases. We hope that our research will provide novel insights into BPD and NEC pathogenesis in neonates that will translate to better options for disease diagnosis and treatment. Current projects include: 1. Regulation of lung endothelial inflammation in the developing lung, 2. Mechanisms underlying impaired vascular development in BPD, 3. Role of TRIP-1 role in lung injury and repair. 4. Animal models to dissect the role of aberrant innate immune signaling in NEC, 5. Genomic susceptibility of NEC and sepsis phenotypes in newborn babies, 6. Effect of sepsis on lung TGFβ signaling and abnormal lung development.

Internal Medicine-Adult, Oncology, Pathology

Pathology

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Affiliated Faculty

Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
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Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

CDC funded use of laboratory and medical data warehouses to support quality improvement.

Pharmacogenomic knowledge representation and decision support.

Influence of patient context on health, what I refer to as the ‘Envirome’.

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Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
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Research Interests

Dermatology case report, derm research project, book chapters and articles reviewing topics in derm, internal medicine, women’s health issues, domestic violence and intimate partner violence, physician burnout, ethics, humanities, reflective writing, creative video projects, empathy and humanism.


Photo of Gary Salzman, M.D.
Gary Salzman, M.D.
Professor of Medicine
  • Specialty: Pulmonary
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: Wake Forest University
  • Pulmonary Fellowship: University of Missouri-Kansas City
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Research Interests

In 1999 UMKC School of Medicine led by Gary A. Salzman MD, FCCP in partnership with Truman Medical Center and Children’s Mercy Hospital established the UMKC Asthma Clinical Research Center (ACRC) funded by a $500,000 grant over five years from the American Lung Association (ALA). In 2004 UMKC was awarded increased funding from the American Lung Association of $750,000 over 5 years.  Recently funding was extended for another 3 years until 2012.  The American Lung Association- Asthma Clinical Research Centers (ALA-ACRC) has successfully completed five clinical trials with several additional trials under way or in preparation. Currently there are 17 clinical centers and a data coordinating center at Johns Hopkins University.

Why did the ALA fund this large network? Health care providers caring for patients with asthma need answers quickly to provide the best care for their patients. Clinical studies performed at one center or even three or four centers may take up to five years to enroll enough subjects to answer such important questions.

The ALA recognized that 17 clinical centers will be able to enroll a large number of subjects in a relatively short period of time so the studies’ results can be published and health care providers can have the answers they need to provide the best evidence-based care to their patients with asthma.

Another advantage of a large network of clinical centers is the ability to enroll subjects from diverse populations. The populations represented in the ALA-ACRC studies include the same type of patients encountered by health care providers across the country.
Five practical and clinically important questions addressed by the ALA-ACRC are summarized below.

Vaccine safety

Is the influenza vaccine safe for patients with asthma?
The ALA-ACRC Network’s first endeavor was the Study of Inactivated Influenza Vaccine in Asthmatics (SIIVA). Influenza causes substantial morbidity in adults and children with asthma. However, the rate of vaccination for patients with asthma has been low partly due to fears of increased exacerbations from the vaccine.

The purpose of SIIVA was to evaluate the safety of the influenza vaccine in patients with asthma. The trial enrolled 2,032 participants in a three-month period between September and November 2000. Results showed rates of asthma exacerbations between vaccine and placebo injections were equivalent in a diverse population of adults and children with asthma, including severe asthma.  The results were published in the New England Journal of Medicine.

Health care providers should encourage patients with asthma to be immunized. Not only is the vaccine safe in this population, but vaccination also reduces the morbidity and mortality associated with influenza in patients with asthma.

Add-on controller medications

Which add-on controller medications work well for patients with uncontrolled asthma?
The ALA-ACRC Network’s second clinical trial was the Effectiveness of Low Dose Theophylline as Add-On Therapy in Treatment of Asthma (LODO).  Current guidelines recommend adding a controller medication to the treatment regimen of poorly controlled patients with asthma. Theophylline, a relatively inexpensive asthma medication, and anti-leukotriene agents such as montelukast, are convenient choices because both are once-a-day medications taken by mouth.
The comparative effectiveness of these two add-on treatments for poorly controlled asthma is unknown. LODO is the first clinical trial to directly compare theophylline to both active (montelukast) and placebo control.

The study enrolled 489 adolescents and adults with poorly controlled asthma over an 11-month period between 2001 and 2002.  The primary outcome was the rate of episodes of poor asthma control (EPACs). An EPAC is a composite measure of asthma control including measures of asthma control, need for medical care, and lung function.

Results showed neither low-dose theophylline nor montelukast decreased the rate of EPACs in patients with poorly controlled asthma as compared to the placebo group.  Both treatments did, however, improve lung function as measured by spirometry.

In a sub-group of patients not taking inhaled corticosteroids (ICS), monotherapy low-dose theophylline resulted in both statistically and clinically significant improvements in asthma control and symptoms. Montelukast was less effective in patients not on an ICS. As such, low-dose theophylline may provide an effective, safe and low-cost treatment alternative for patients with poorly controlled asthma who can’t or won’t use ICS because of side effects, preference, or cost.

Step-down therapy

Which step-down therapy options work well for patients with mild asthma?

Current guidelines for the treatment of patients with mild persistent asthma are to establish control of symptoms using inhaled corticosteroids and then “step-down” therapy to the minimum needed to maintain control. Although step-down therapy has been studied in patients with moderate to severe asthma, it hasn’t been systematically evaluated in patients with mild asthma. This was the purpose of the Leukotriene Modifier or Corticosteroids or Corticosteroid-Salmeterol (LOCCS) trial.

A large number of patients with asthma have a mild form of the disease. Encouraging patient adherence to asthma treatment regimens continues to present challenges. Providing patients with convenient, efficacious alternative treatments associated with fewer side effects could enhance adherence and reduce unnecessary medication exposure.

This clinical trial compared three alternative treatments for patients whose asthma was well controlled on low-dose inhaled corticosteroids. The treatment groups were fluticasone (100 mg twice a day), fluticasone plus salmeterol (100/50 mg once daily) or montelukast (10 mg or 5 mg daily for adults and children, respectively). The study randomized 500 children and adults; participant follow-up was completed in July 2005.

Results showed patients with asthma well controlled on twice-daily inhaled fluticasone can be stepped-down to once daily fluticasone/salmeterol without increased rates of treatment failure.

Stepping-down to montelukast resulted in an increase in treatment failures and decreased asthma control. Notably, however, there were a high number of symptom-free days for patients in all treatment groups, including 79 percent of days for patients taking montelukast over a four-month follow-up period.  Hence, oral montelukast isn’t as effective as either low-dose ICS (twice a day) or a low-dose ICS with salmeterol (once daily), but montelukast still provided good asthma control for most patients. The results were published in the New England Journal of Medicine.

Patient education

Are the effects of patient education real or not?

The Trial of Asthma Patient Education (TAPE) was designed to evaluate the effect of patient education on the treatment response to both placebo and montelukast. The National Heart Lung Blood Institute-funded trial completed enrollment in 2005, eight months ahead of schedule.

Patients randomized to montelukast or placebo was randomized again to receive either an enhanced presentation of the study treatment or a neutral presentation. The enhanced presentation was designed to increase expectancy of therapeutic benefit.

We compared effects of the enhanced presentation independently in the montelukast and placebo groups. This comparison addressed the question — does increasing expectancy improve outcomes equally in active treatment and placebo groups?

The usual care group was compared to the placebo group receiving the neutral presentation to estimate the placebo effect. Results showed the placebo and education effects were small for measures of lung function. However, there were effects on symptom indices such as Asthma Control Score.

Furthermore, “nocebo” effects were observed on side effects, such that more patients reported headache in the placebo group after receiving information about possible side effects than those on placebo who didn’t receive similar information. These results address the specific question about the best ways to evaluate new therapies for asthma and, more generally, how the use of placebo may affect the results of clinical trials.

The main results of the trial are currently being prepared for publication as well as results from several sub-studies evaluating adherence and education effects.

GERD & asthma

Can treatment with a proton pump inhibitor (PPI) of gastroesophogeal reflux disease improve asthma control?

GERD is common in patients with asthma, even in patients who have no symptoms of heartburn. It’s predicted that GERD may contribute to poor control of asthma but its unknown if empiric treatment of GERD in patients with poorly controlled asthma can improve control.

Two complementary clinical trials funded by the NHLBI in adults and children were  conducted by the ALA-ACRC. Both trials examine whether treatment with a PPI for GERD will improve asthma control in patients with poorly controlled asthma despite relatively high doses of inhaled steroids. Subjects undergo esophageal pH monitoring for the accurate diagnosis of GERD and have methacholine challenge testing to determine changes in bronchial reactivity. The adult study was completed in 2009 and demonstrated no improvement in asthma control with high dose proton pump inhibitor treatments. The results were published in the New England Journal of Medicine.  The pediatric study will be completed in 2011.

The ALA-ACRC has provided answers to important clinical questions for health care providers working in the trenches caring for asthma patients every day. Investigators on the ALA-ACRC steering committee are planning several future studies to improve the quality of life for adults and children living with asthma.  We recently have acquired funding from the NIH for two additional studies.  One study evaluates the administration of Soy supplements to uncontrolled asthmatics to determine if there is improved asthma control.  The other study evaluates the treatment of allergic rhinitis/sinusitis on asthma control.

The UMKC ACRC is one 17 centers nationwide undertaking a multi-center research approach to discovering improved methods to manage asthma with the long term goal to find a cure for asthma.  UMKC joins Johns Hopkins, Duke, Washington University in St. Louis, and many other prestigious universities in the largest industry independent research consortium to ever study asthma.

UMKC Lung Research Center

The Lung Research Center at UMKC was started by Dr. Salzman in 2005 to expand on the successes in clinical asthma research to include collaboration with UMKC basic science researchers.  Areas of planned studies include metabolic bone disease related to the use of systemic corticosteroids, discovery of novel mechanisms of disease in sarcoidosis, lung injury related to fat embolism from long bone fractures, and the genetic characteristics of asthma.

The collaboration of the clinical and basic science investigators with expertise in many aspects of lung disease will lead to significant discoveries that will be taken from bench to bedside to improve the treatment for many types of lung disease.  The addition of an endowed chair in lung research will serve as a catalyst for the expansion of research activities and funding.  Building on the strong foundation of existing funding and the talent of existing faculty the UMKC Lung Research Center will obtain international prominence in the next five years.

Peer Reviewed Publications

The American Lung Association Asthma clinical Research Centers (including GA Salzman). Clinical Trial of Low-dose Theophylline and Montelukast in Patients with Poorly Controlled Asthma. AJRCCM 2007. 175:235-242

The American Lung Association Asthma Clinical Research Centers (including GA Salzman). Randomized Comparison of Strategies for Reducing Treatment in Mild Persistent Asthma. N Eng J Med 2007; 356:2027-2039

Salzman GA. Smoking Ruins, The Prevention of Lung Disease. Missouri Medicine 2007; 104 (3): 208-209.

Khan ZU, Salzman GA. Management of Sepsis: The Surviving Sepsis Guidelines for Early Therapy. Hospital Physician 2007; 55:21-30.

The American Lung Association Asthma Clinical Research Center (including GA Salzman). Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma. N Engl J Med 2009;360:1487-99.

M Das, GA Salzman. Pulmonary Alveolar Proteinosis: An Overview for Internists and Hospital Physicians. Hospital Practice 2010;38(1):277-280.

Cox LS, Faseru B, Mayo MS, Krebill R, Snow TS, Bronars CA, Nollen NL, Choi WS, Okuyemi KS, Salzman GA, Benowitz NL, Tyndale RF, Ahluwalia JS. Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials 2011, 12:22

Jallu SS, Salzman GA. A Case-Based Approach to Noninvasive Positive Pressure Ventilation. Hospital Practice 2011; 39(3):168-175.

The American Lung Association Asthma Clinical Research Center (including GA Salzman). Lansoprazole for Children with Poorly Controlled Asthma. JAMA. 2012;307(4):373-381

Saettele TM, Mohr J. Evaluation and Management of Acute Kidney Injury in the Intensive Care Unit. Missouri Medicine 2012:109(5):379-383

Research Support

The Leukotriene Modifier Or Corticosteroids Trial (The LOCS Trial):

A Comparison of Continued Low-Dose Inhaled Corticosteroids versus Leukotriene Modifier for Asthmatic Patients Well Controlled with Low Dose Inhaled Corticosteroids, Principal investigator. Funding from GlaxoSmithKline $4,633,888 total funding over 5 years to Asthma Clinical Research Centers 2001-2006 One of 19 principal investigators.

The Trial of Asthma Patient Education, Funding from National Heart, Blood and Lung Institute $2,570,617 total funding over 4 years to Asthma Clinical Research Centers 2002-2006. One of 19 principal investigators

Study of Acid Reflux in Asthma, Funding from National Heart, Blood and Lung Institute $3,800,627 total funding over 5 years to Asthma Clinical Research Centers 2004-2009. One of 19 principal investigators

Study of Acid Reflux in Childhood Asthma, Funding from National Heart, Blood and Lung Institute $2,414,841 total funding over 5 years to Asthma Clinical Research Centers 2007-2012 One of 20 principal investigators

American Lung Association: Asthma Clinical Research Center: 2009-2012 for $300,000. Principal Investigator

Missouri Hospital Association Regional Health Partnership Grant for Asthma Education and Research Programs- $100,000; 2002-2006. Principal Investigator

Blue Cross and Blue Shield of Kansas City: $49,875. Developing a culturally tailored smoking cessation program for heavily addicted Chronic Obstructive Pulmonary Disease (COPD) patients; Principal Investigator 2007-2009

American Lung Association Asthma Clinical Research Centers (ACRC)
The Study of Soy Isoflavones in Asthma (SOYA) National Heart, Blood and Lung Institute: R01 HL0088367-01A2- total funding $1.5 million- one of 18 ACRC multi-center co-investigators 2010-2013

American Lung Association Asthma Clinical Research Centers (ACRC) Study of Asthma and Nasal Steroids (STAN) National Heart, Blood and Lung Institute: U01 HL00895101-01A2- total funding $2.1
One of 18 ACRC multi-center co-investigators 2010-2013

Geldmacher Pulmonary Fibrosis Research Center 2012-2017 $400,000 Principal Investigator


Photo of Lamont G. Weide, M.D., Ph.D.
Lamont G. Weide, M.D., Ph.D.
Professor Department of Internal Medicine
  • Specialty: Endocrinology and Metabolism
  • Medical School: University of Texas, San Antonio
  • Doctoral Degree: University of Texas, Dallas
  • Postdoctoral Training: University of Texas, San Antonio
  • Internal Medicine Residency: Indiana University Medical Center
  • Endocrinology and Metabolism Fellowship: Washington University, St. Louis
  • Research Interests: Diabetes, Thyroid Cancer

Medical Humanities & Bioethics

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Medical Humanities and Bioethics

Affiliated Faculty

Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
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Research Interests

Dermatology case report, derm research project, book chapters and articles reviewing topics in derm, internal medicine, women’s health issues, domestic violence and intimate partner violence, physician burnout, ethics, humanities, reflective writing, creative video projects, empathy and humanism.


Photo of Gary Sutkin, M.D., M.B.A.
Gary Sutkin, M.D., M.B.A.
Professor and Program Director Associate Dean of Women’s HealthVictor and Caroline Schutte Chair in Women’s Health

Professor, Department of Biomedical and Health Informatics (Tenure) and Obstetrics and Gynecology

  • M.D. Degree: Northwestern University
  • M.B.A. Degree: J.L. Kellogg Graduate School of Management
  • Residency: Magee Womens Hospital, Pittsburgh, PA
  • Fellowship: Magee Womens Hospital, Pittsburgh, PA
  • Certification: American Board of Obstetricians and Gynecologists, Subspecialty Female Pelvic Medicine and Reconstructive Surgery
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Biography

Gary Sutkin is the Associate Dean and Victor and Caroline Schutte Chair in Women’s Health. He is a Professor with tenure in the Department of Obstetrics and Gynecology and the Department of Biomedical and Health Informatics.

Dr. Sutkin comes to the University of Missouri Kansas City from the University of Pittsburgh. There he was in the Academy of Master Educators and directed the Obstetrics and Gynecology core clerkship. His research centered on surgical education and the prevention of postoperative urinary tract infections. He was a co-investigator in the NIH Pelvic Floor Disease Network. He contributed to the establishment of the Nazarbayev School of Medicine in Astana Kazakhstan.

Dr. Sutkin’s research interests center on surgical safety and error prevention. He is interested in how communication between attending and resident surgeons impact patient outcome. He collaborates with a cognitive psychologist and members of the Department of Civil and Mechanical Engineering.

He is a practicing Urogynecologist and specializes in women with pelvic floor prolapse. He provides both reconstructive pelvic surgery and non-surgical treatments for women with pelvic organ prolapse, urinary incontinence, and other pelvic floor disorders.

Dr. Sutkin was born in San Antonio and grew up in Richardson, Texas. He attended Northwestern University’s Honors Program in Medical Education, worked at the federal Reserve bank in Chicago, and attained his BS, MD, and MBA degrees at Northwestern. He is an avid Northwestern fan.

Awards
  • Association of Professors of Gynecology and Obstetrics Teaching Award – 2002
  • Association of Professors of Gynecology and Obstetrics/Solvay Scholar – 2002-2003
  • Alpha Omega Alpha Society – 2003
  • Texas Tech University Health Sciences Center Dean’s Clinical Science Teaching Award – 2006
  • Council on Resident Education in Obstetrics and Gynecology Teaching Award – 2011
  • Residency Program Top 10% Golden Apple Teaching Award – 2011
  • Appointment to University of Pittsburgh School of Medicine Academy of Master Educators – 2012
  • Finalist, Patil Teaching Innovation Award – 2015
Research Interests
  • Surgical error prevention and communication
  • Intraoperative teaching
  • Midurethral sling surgery
  • Postoperative Urinary tract infections
Selected Publications
  1. Sutkin G, Littleton E, Kanter S. Intelligent cooperation: A framework of pedagogic practice in the operating room. Am J Surg. 2017 Publication Pending
  2. Oliphant S, Littleton E, Gosman G, Sutkin, G. Teaching the Retropubic Midurethral Sling  Using a Novel Cadaver and Model-Based Approach. Cureus. 2017; 9(5): e1214. DOI 10.7759/cureus.1214. PMID:PMC5453826.
  3. Paradis E, Sutkin G. Beyond a Good Story: From Hawthorne Effect to Reactivity in Health Professions Education Research. Medical Education. 2016 PMID: 27580703.
  4. Markland AD, Jelovsek E, Whitehead WE, Andy UU, Newman DK, Dyer K, Harm-Ernandes I, Cichowski S, McCormick J, Rardin C, Sutkin G, Shaffer A, Meikle S. Implementation of a Multi-site Manometric Biofeedback Intervention with Anorectal Manometry for the Treatment of Fecal Incontinence in Women. Neurogastroenterology and Motility. 2016 PMID: 27453154.
  5. Lowder J, Oliphant S, Shepherd J, Ghetti C, Sutkin G. Genital Hiatus Size is Associated with and Predictive of Apical Vaginal Support Loss. Am J Obstetrics Gynecology. 2015; PMID: 26719211
  6. J. Eric Jelovsek, Alayne D. Markland , William E. Whitehead, Matthew D. Barbe, Diane K. Newman, Rebecca G. Rogers, Keisha Dyer, Anthony Visco, Vivian W. Sung MD, Sutkin G, Susan F. Meikle Marie G. Gantz. Controlling anal incontinence by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods. Contemp Clin Trials. 2015;44, 164-74. PMID: 26291917
  7. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 2: Physical teaching guidance. Journal of Surgical Education. 2015; 72(2), 251-7. PMID: 25468768
  8. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 1: Verbal teaching guidance. Journal of Surgical Education. 2015;72(2), 243-50. PMID: 25456208
  9. Zimmern P, Litman HJ, Nager CW, Lemack GE, Richter HE, Sirls L, Kraus SR, Sutkin G, Mueller ER. Effect of aging on storage and voiding function in women with stress-predominant urinary incontinence. J Urol. 2014 Feb 8. pii: S0022-5347(14)00131-1. doi: 10.1016/j.juro.2014.01.092. PMID: 24518790.
  10. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013;2013:926313.  doi: 10.1155/2013/926313. Epub 2013 Sep 8. PMID: 24194763; PMCID: PMC3782123.
  11. Sutkin G, Dzialowski K. A gynaecologic clinic dedicated to student teaching. Clin Teach. 2013 Jun;10(3):181-5. doi: 10.1111/j.1743-498X.2012.00633.x. PMID: 23656681
  12. Nager CW, Brubaker L, Litman HJ, Zyczynski HM, Varner RE, Amundsen C, Sirls LT, Norton PA, Arisco AM, Chai TC, Zimmern P, Barber MD, Dandreo KJ, Menefee SA, Kenton K, Lowder J, Richter HE, Khandwala S, Nygaard I, Kraus SR, Johnson HW, Lemack GE, Mihova M, Albo ME, Mueller E, Sutkin G, Wilson TS, Hsu Y, Rozanski TA, Rickey LM, Rahn D, Tennstedt S, Kusek JW, Gormley EA; Urinary Incontinence Treatment Network. A randomized trial of urodynamic testing before stress-incontinence surgery. N Engl J Med. 2012 May 24;366(21):1987-97. doi: 10.1056/NEJMoa1113595. Epub 2012 May 2. PMID: 22551104; PMCID: PMC3386296
  13. Skoczylas LC, Littleton EB, Kanter SL, Sutkin G. Teaching techniques in the operating room: the importance of perceptual motor teaching. Acad Med. 2012 Mar;87(3):364-71. doi: 10.1097/ACM.0b013e31824484a0. PMID: 22373633.
  14. Nygaard I, Brubaker L, Chai TC, Markland AD, Menefee SA, Sirls L, Sutkin G, Zimmern P, Arisco A, Huang L, Tennstedt S, Stoddard A. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011 Oct;22(10):1255-65. doi: 10.1007/s00192-011-1429-9. Epub 2011 May 11.  PMID: 21560012.
  15. Martirosian Smith TE, Trowbridge ER, Pastore LM, Smith SC, Brennan MC, Dooley Y, Matthews CK, Ozel B, Sutkin G, Hullfish KL. Multicenter Urogynecology Study on Education: Medical Student Educational Experiences and Knowledge Outcomes During the OBGYN Clerkship. Female Pelvic Med Reconstr Surg. 2011 Mar;17(2):100-104. PMID: 22453697.
  16. Sutkin G, Daucher J, Zyczynski H. Prolapse in the Older Woman. European Urologic Review. 2010;5:64-8.
  17. Park AJ, Barber MD, Bent AE, Dooley YT, Dancz C, Sutkin G, Jelovsek JE. Assessment of intraoperative judgment during gynecologic surgery using the Script Concordance Test. Am J Obstet Gynecol. 2010 Sep;203(3):240.e1-6. doi: 10.1016/j.ajog.2010.04.010. Epub 2010 May 21. PMID: 20494330.
  18. Nager CW, Kraus SR, Kenton K, Sirls L, Chai TC, Wai C, Sutkin G, Leng W, Litman H, Huang L, Tennstedt S, Richter HE; Urinary Incontinence Treatment Network. Urodynamics, the supine empty bladder stress test, and incontinence severity. Neurourol Urodyn. 2010 Sep;29(7):1306-11. doi: 10.1002/nau.20836. PMID: 20127832.
  19. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug;21(8):955-61. doi: 10.1007/s00192-010-1137-x. Epub 2010 Mar 31. PMID: 20354678.
  20. Sutkin G, Littlefield JH, Laube DW. Nursing staff assessment of residents’ professionalism and communication skills. Med Educ. 2009 Nov;43(11):1104. doi: 10.1111/j.1365-2923.2009.03461.x. Epub 2009 Oct 2. PMID: 19799729.
  21. Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CISC) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Aug;20(8):933-8. doi: 10.1007/s00192-009-0885-y. Epub 2009 Apr 10. PMID: 19582384.
  22. Sutkin G, Aronoff CK. Resident front office experience: a systems-based practice activity. Med Educ Online. 2008 May 28;13:6. doi: 10.3885/meo.2008.T0000120. PMID: 20165536; PMCID: PMC2779599.
  23. Sutkin G, Wagner E, Harris I, Schiffer R. What makes a good clinical teacher in medicine? A review of the literature. Acad Med. 2008 May;83(5):452-66. doi: 10.1097/ACM.0b013e31816bee61. Review. PMID: 18448899.
  24. Sutkin G, Burley H, Zhang K, Arora N. Characteristics of good clinical educators from medical students perspectives: A Qualitative inquiry using a web-based survey system. International Journal of Healthcare Information Systems and Informatics. 2008;3(2):69-86.
  25. Sutkin G, Krohn MA, Heine RP, Sweet RL. Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. Obstet Gynecol. 2005 Mar;105(3):581-6. PMID: 15738028.
  26. Sutkin G, Mamlok V. Images in clinical medicine. Fetus papyraceus. N Engl J Med. 2004 Apr 15;350(16):1665. PMID: 15084699.

Complete list of publications


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

I lead multiple research projects in the areas of Autism Spectrum Disorders and Developmental Disabilities: One series of projects is focused on autism and developmental screening in primary care medical settings. We have an ongoing quality improvement initiate at Children’s Mercy, which has yielded a large health database. We have use this database for additional projects related to health disparities and health outcomes related to screening. I am interested in research related to parenting and autism/developmental disabilities, health care access, health & treatment outcomes, dissemination, and the education and training of healthcare professionals about developmental disabilities. Finally, I am the site PI for a large epidemiological study on autism and developmental disabilities funded by the Centers for Disease Control.


Photo of Erin M. Guest, M.D.
Erin M. Guest, M.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Cancer genomics research, Infant leukemia, clinical and genomics research.

Neurology/Neuroscience, Psychiatry

Neurology

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Affiliated Faculty

Photo of Nash N. Boutros, MBBCH
Nash N. Boutros, MBBCH
Department Chair and Professor Center for Behavioral MedicinePsychiatry
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Research Interests

Coherence abnormalities in panic disorder; relationship to epilepsy. Coherence abnormality in psychogeneic non-epileptic seizures. EEG and MEG abnormalities in schizophrenia.


Photo of Keith Coffman, M.D.
Keith Coffman, M.D.
Associate Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology
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Education
  • Medical School: Pennsylvania State University College of Medicine
  • Residency: Children’s Hospital of Pittsburgh – Neurodevelopmental Disabilities
  • Fellowship: University of Pittsburgh School of Medicine – Pediatric Scientist Development Program
Research Interests
  • Analysis of androgens in Tourette Syndrome. We hypothesize that patients with Tourette Syndrome have higher excretion of androgens compared to age matched controls. This may be part of the reason that Tourette is more common in young men, and typically worsens around the onset of puberty.
  • Repetitive transcranial magnetic stimulation (rTMS)to treat Tourette Syndrome. There is early data to indicate that rTMS may be effective for treating Tourette. We have partnered with an external colleague who has a novel, patented rTMS device that we will be trialing as a treatment for patients affected by Tourette.
  • Prospective, multicenter analysis of sleep disorders in medication naïve patients with Tourette Syndrome. We have some preliminary data that indicates that patients with Tourette may have higher rates of restless leg syndrome and other sleep disorders. We will use standardized sleep questionnaires, analysis of serum ferritin levels, and Yale Global Tic Severity scales to assess these patients.
  • Neuropsychological profiles of patients with Tourette Syndrome. Out neuropsychologist, Josh Hall, has accumulated years of data on patients with Tourette. There is precious little data on the neuropsychological deficits seen in Tourette. We plan to analyze the accumulated clinical data on our patient population and see if specific patterns of deficits are present in this patient population.
  • Behavioral patterns of patients with Tourette. One of our nurse practitioners, Laura Banning, plans to analyze patterns of maladaptive behavior in patients with Tourette using the Child Behavior Checklist (CBCL).

For additional information, please click here.

 


Jessica A. Hellings, M.B.B.Ch.
Professor, University of Missouri-Kansas City Center for Behavioral MedicinePsychiatry
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Research Interests

Psychopharmacology studies of old drugs in autism: Loxapine, amitriptyline, dextroamphetamine, BDNF Attachment in Developmental Disabilities ADHD in ASD/DD Psychological mindedness Gluten allergy, celiac disease and neuropsychiatric illness; gut-brain biology in neuropsychiatric illness.



Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital
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Research Interests

I am willing to tailor projects to meet the needs of students; however, they should be in my discipline of Pediatric or Adult Physical Medicine and Rehabilitation. Some unique areas of interest are: Cerebral palsy Clinical pharmacology Spasticity management Adaptive sports Disability populations Concussion Traumatic brain or spinal cord injury.


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

I lead multiple research projects in the areas of Autism Spectrum Disorders and Developmental Disabilities: One series of projects is focused on autism and developmental screening in primary care medical settings. We have an ongoing quality improvement initiate at Children’s Mercy, which has yielded a large health database. We have use this database for additional projects related to health disparities and health outcomes related to screening. I am interested in research related to parenting and autism/developmental disabilities, health care access, health & treatment outcomes, dissemination, and the education and training of healthcare professionals about developmental disabilities. Finally, I am the site PI for a large epidemiological study on autism and developmental disabilities funded by the Centers for Disease Control.


Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education
  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials
Research Interests

Bilirubin neurotoxicity, kernicterus, neurodevelopmental disorders, auditory neurology, movement disorders, clinical neurophysiology.

For additional information, please click here.

 

Obstetrics & Gynecology

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Obstetrics and Gynecology

Affiliated Faculty
Photo of Timothy G. Myrick, M.D.
Timothy G. Myrick, M.D.
Assistant Professor, University of Missouri-Kansas City Truman Medical CenterCommunity & Family Medicine
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Research Interests

Vaginal lacerations.

Pediatrics

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Pediatrics

Affiliated Faculty

Photo of Susana Chavez-Bueno, M.D.
Susana Chavez-Bueno, M.D.
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Discovery of virulence factors in Escherichia coli strains that cause neonatal sepsis. Molecular epidemiology of neonatal Escherichia coli bacteremia strains.


Photo of Erin M. Guest, M.D.
Erin M. Guest, M.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Cancer genomics research, Infant leukemia, clinical and genomics research.


Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
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Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

CDC funded use of laboratory and medical data warehouses to support quality improvement.

Pharmacogenomic knowledge representation and decision support.

Influence of patient context on health, what I refer to as the ‘Envirome’.

View CV


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

I lead multiple research projects in the areas of Autism Spectrum Disorders and Developmental Disabilities: One series of projects is focused on autism and developmental screening in primary care medical settings. We have an ongoing quality improvement initiate at Children’s Mercy, which has yielded a large health database. We have use this database for additional projects related to health disparities and health outcomes related to screening. I am interested in research related to parenting and autism/developmental disabilities, health care access, health & treatment outcomes, dissemination, and the education and training of healthcare professionals about developmental disabilities. Finally, I am the site PI for a large epidemiological study on autism and developmental disabilities funded by the Centers for Disease Control.


Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
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Research Interests

Investigate the roles and molecular mechanisms of nicotinamide phosphoribosyltransferase in acute respiratory distress syndrome, arthritis, drug induced liver injury.

Identify new genetic risk factors underlying complex diseases using next generation DNA sequencing technologies.

Apply Translational Bioinformatics to leverage ‘Big Data’ to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.


Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics
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Research Interests

Dr. Sampath, a physician-scientist in Neonatology, is passionate about understanding the why and how behind babies developing severe lung (BPD) and intestinal (NEC) disease using his expertise in innate immune signaling. Laboratory members study various aspects of neonatal lung disease (BPD) and bowel disease (NEC) using a team science approach. We use complementary approaches involving transgenic mice, cell-culture experiments and human genetics to identify the mechanisms regulating development of these diseases. We hope that our research will provide novel insights into BPD and NEC pathogenesis in neonates that will translate to better options for disease diagnosis and treatment. Current projects include: 1. Regulation of lung endothelial inflammation in the developing lung, 2. Mechanisms underlying impaired vascular development in BPD, 3. Role of TRIP-1 role in lung injury and repair. 4. Animal models to dissect the role of aberrant innate immune signaling in NEC, 5. Genomic susceptibility of NEC and sepsis phenotypes in newborn babies, 6. Effect of sepsis on lung TGFβ signaling and abnormal lung development.


Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education
  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials
Research Interests

Bilirubin neurotoxicity, kernicterus, neurodevelopmental disorders, auditory neurology, movement disorders, clinical neurophysiology.

For additional information, please click here.

 

Radiology

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Radiology

Under Construction