Research

Research Topics & Faculty – Grad Students

The School of Medicine is focused on advancing excellence in health outcomes, informatics, patient safety and community health, and it actively supports research in these areas. Through its esteemed faculty, exceptional students and residents, and more than 20 endowed chairs leading research efforts, UMKC School of Medicine is leading a successful effort to build biomedical research programs that are responsive to medical conditions in our community.

Anesthesiology, Surgery, Orthopaedic Surgery

Orthopaedics

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Affiliated Faculty

Photo of Xiang-Ping Chu, M.D., Ph.D.
Xiang-Ping Chu, M.D., Ph.D.
Associate Professor with Tenure Biomedical Sciences, Neuroscience Work M3-417 Work Phone: (816) 235-2248
  • Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Postdoctoral Fellowship (Neurobiology, 2004)
  • Fudan University Shanghai Medical College, Ph.D. (Physiology, 1999)
  • Fudan University Shanghai Medical College, MS (Physiology 1996)
  • Jiangsu University School of Medicine, MD (Clinical Medicine, 1989)
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Biography

Dr. Chu earned his medical degree from Jiangsu University School of Medicine in 1989, and his PhD degree from Fudan University Shanghai Medical College in 1999, both in the People’s Republic of China. He then came to America for postdoctoral training at the Legacy Research Institute in Portland, Oregon in 2000. He received a postdoctoral fellowship from the American Heart Association (AHA) in 2002 and subsequently received a beginning grant-in-aid in 2004 and scientist development grant in 2007, both from the AHA. While at the Legacy Research Institute, Dr. Chu was promoted from research associate to senior research associate, to assistant scientist. In 2008, he was recruited to the UMKC School of Medicine as a tenure-track Assistant Professor to establish an advanced, independent electrophysiology laboratory in a strategic expansion of neuroscience research program. In 2014, Dr. Chu was promoted to Associate Professor with tenure. His research focuses on the role of ion channels and membrane receptors in the pathogenesis of neurological disorders such as stroke and drug addiction. While at UMKC, his research has been supported by the National Institute of Health (NIH) and the AHA. Dr. Chu teaches medical neuroscience and physiology courses and is a member of UMKC’s doctoral faculty. He has published 3 book chapters and more than 50 peer-reviewed articles with an H-index of 18, and has served as a peer-reviewer for over 30 scientific journals. Dr. Chu currently serves on Editorial Boards for Advances in Neuroscience, International Journal of Physiology, Pathophysiology & Pharmacology (IJPPP), ISRN Physiology, and Scientific Reports. Dr. Chu also serves on grant study sections for the AHA, Medical Research Council of UK, Ataxia Foundation of UK, and the University of Missouri Research Board (UMRB).

Research Interest

One of my research interests is to understand the functional role of ion channels in ischemic brain injury. Brain ischemia induces various biochemical changes, which can activate various ion channels, including Acid-Sensing Ion Channels (ASICs). During hypoxia/ischemia, increased anerobic glycolysis due to the lack of blood and oxygen supply leads to lactic acid accumulation, causing a reduction in pH, and acidosis. For many years, acidosis has been known to play an important role in the pathology of neuronal injury. However, the cellular and molecular mechanisms underlying acidosis-induced injury remain elusive. Recently we have demonstrated that activation of newly described

ASICs contribute to neuronal injury, particularly those containing the ASIC1a subunit. My aim is to explore the potential mechanisms by which ASIC’s are involved in the pathogenesis of ischemic brain injury, particularly the extent to which they might be modulated/regulated by endogenous molecules (e.g. glucose and zinc). ASICs localize to synapses and proton as a neurotransmitter released from synaptic vesicles activates ASICs during neurotransmission. I am also interested in studying the functional role of ASICs in the brain and the interaction between ASICs and other ion channels/receptors (for example, glutamate receptors, dopamine receptors et al.,) during physiological or pathological conditions such as drug abuse. We want to determine whether ASICs play any roles in the pathogenesis of drug abuse or interact with other receptors in the brain in response to psychostimulants.

Mentoring Area

I am interested in mentoring students who have interests in neurological diseases such as drug abuse and ischemic brain injury using a combination of patch-clamp recording, fluorescence-imaging, gene transfection and knockdown, cell injury assay and behavior measurement techniques.

Recent Publications

*Chu XP, Grasing KA, Wang JQ. Acid-sensing ion channels contribute to neurotoxicity. Transl Stroke Res. 5(1):69-78, 2014. *Corresponding author.

Jing L, *Chu XP, *Zha XM. Three distinct motifs within the C-terminus of ASIC1a regulate its surface trafficking. Neuroscience. 247: 321-327, 2013. *Corresponding author.

Jiang Q, Wang CM, Fibuch EE, Wang JQ, *Chu XP. Differential regulation of locomotor activity to acute and chronic cocaine administration in acid-sensing ion channels 1a and 2 in adult mice. Neuroscience. 246C:170-178, 2013. *Corresponding author.

*Chu XP, Xiong ZG. Acid-sensing ion channels in pathological conditions. Adv Exp Med Biol. 961:419-31, 2013. *Corresponding author.

Jiang Q, Zha XM, *Chu XP. Inhibition of human acid-sensing ion channel 1b by zinc. Int J Physiol Pathophysiol Pharmacol4(2):84-93, 2012. *Corresponding author.

Wang JQ, Chu XP, Guo ML, Jin DZ, Xue B, Berry TJ, Fibuch EE, Mao LM. Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide. Front Physiol. 3:164, 2012.

*Chu XP, *Jing L,*Jiang YQ, Collier DM, Wang B, Jiang Q, Snyder PM and Zha XM. N-Glycosylation of ASIC1a regulates its trafficking and acidosis-induced spine remodeling. J Neurosci.  32(12):4080-4091, 2012. *These authors contributed equally.

*Chu XP, Xiong ZG. Physiological and pathological functions of acid-sensing ion channels in central nervous system. Curr Drug Targets. 13(2):263-271, 2012. *Corresponding author.

*Chu XP, Papasian CJ, Wang JQ and Xiong ZG. Modulation of Acid-Sensing Ion Channels: Molecular Mechanisms and Therapeutic Potential. Int J Physiol Pharmacol. 3(4):288-308, 2011. *Corresponding author.

Jing L, Jiang Q, Jiang YQ, Chu XP, and Zha XM. Interaction between the first transmembrane domain and the wrist of acid-sensing ion channel 1a is critical for its maturation and trafficking.  PLoS One, 6(10):e26909, 2011.

Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG, *Chu XP. Cysteine 149 in the extracellular finger domain of ASIC1b subunit is critical for zinc-mediated inhibition. Neuroscience, 193: 89-99, 2011. *Corresponding author.

Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 31: 2101-2112, 2011.

Van Dolah DK, Mao LM, Shaffer C, Guo ML, Fibuch EE, Chu XP, Buch S, Wang JQ. Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Bio Psychiatry. 69: 1035-1042, 2011.

Lin J, Chu XP, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong ZG. Inhibition of acid-sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 112:977-981, 2011.

*Chu XP, *Coombes E, *Jiang J, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiological relevant levels of hydrogen peroxide induces glutamate-independent neurodegeneration that involves activation of TRPM7 channels. Antioxid Redox Signal. 14: 1815-1827, 2011. *These authors contributed equally.

Suman A, Mehta B, Guo ML, Chu XP, Fibuch EE, Mao LM and Wang JQ. Alterations in acid-sensing ion channel expression in the rat forebrain following chronic amphetamine administration. Neurosci Res. 68: 1-8, 2010.

Jiang Q, Papasian CJ, Wang JQ, Xiong ZG and *Chu XP. Inhibitory regulation of acid-sensing ion channel 3 by zinc. Neuroscience. 169: 574-583, 2010. *Corresponding author.

*Chu XP, *Mao LM, *Wang W, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ, Fibuch EE, Buch S, Chen JG, Wang JQ. Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12: 602-10, 2009. *These authors contributed equally.

Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, *Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 162: 55-66, 2009. *Corresponding author.

Zhang GC, Mao LM, Wang JQ, *Chu XP. Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo. Neurosci Lett. 459:119-22, 2009. *Corresponding author.

Jiang J, Li MH, Inoue K, Chu XP, Seeds J, and Xiong ZG. TRPM7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res.,67:10929-38, 2007.

Liu X, Chu XP, Mao L, Wang M, Lan H, Li MH, Zhang G, Parelkar NK, Haines M, Neve KA, Liu F, Xiong ZG, and Wang JQ. Modulation of D2R/NR2B interactions in response to cocaine. Neuron, 52, 897-909, 2006.

Chu XP, Close N, Saugstad JA, and Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J. Neurosci., 26:5329-5339, 2006.

Xiong ZG, *Chu XP, *Zhu XM, Minami M, Hey J, Wemmie JA, Price M, Welsh MJ, and Simon RP.  Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118(6): 687-698, 2004. *These authors contributed equally.

Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG.   Subunit-dependent High-Affinity Zinc Inhibition of Acid-Sensing Ion Channels. J. Neurosci., 24 (40): 8678-8689, 2004.


Photo of Jonathan Dubin M.D.
Jonathan Dubin M.D.
Assistant Professor – UMKC Truman Medical Center Hospital HillDepartment of Orthopaedic Surgery

A native of Kansas City, Dr. Jonathan Dubin joined the faculty in September 2013. He completed his undergraduate studies with a BS in Neuroscience at Tulane University in 2003 and his MD degree at the University of Kansas in 2007. He spent two years in the University of Illinois-Chicago Orthopaedic Surgery residency before transferring to the San Francisco Orthopaedic Surgery Residency Program, graduating in 2012. Dr. Dubin completed an Orthopaedic Trauma Fellowship at the University of Minnesota-Regions Hospital in 2013. He is board certified by the American Board of Orthopaedic Surgery


Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

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Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

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Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital

Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Kim Smolderen, Ph.D.
Kim Smolderen, Ph.D.
Assistant Professor — Implementation Science Department of Biomedical & Health Informatics
  • 2012, Post-Doctoral Fellowship in Outcomes Research PRT: American Heart Association, St. Luke’s Mid-America Heart Institute
  • 2009, PhD in Medical Psychology, Tilburg University, Tilburg Netherlands
  • Research Interests: Identification of subpopulations at-risk of suboptimal health status and clinical outcomes in cardiac populations, with focus on patients with peripheral arterial disease (PAD).

Photo of Gary Sutkin, M.D., M.B.A.
Gary Sutkin, M.D., M.B.A.
Professor and Program Director Associate Dean of Women’s HealthVictor and Caroline Schutte Chair in Women’s Health

Professor, Department of Biomedical and Health Informatics (Tenure) and Obstetrics and Gynecology

  • M.D. Degree: Northwestern University
  • M.B.A. Degree: J.L. Kellogg Graduate School of Management
  • Residency: Magee Womens Hospital, Pittsburgh, PA
  • Fellowship: Magee Womens Hospital, Pittsburgh, PA
  • Certification: American Board of Obstetricians and Gynecologists, Subspecialty Female Pelvic Medicine and Reconstructive Surgery
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Biography

Gary Sutkin is the Associate Dean and Victor and Caroline Schutte Chair in Women’s Health. He is a Professor with tenure in the Department of Obstetrics and Gynecology and the Department of Biomedical and Health Informatics.

Dr. Sutkin comes to the University of Missouri Kansas City from the University of Pittsburgh. There he was in the Academy of Master Educators and directed the Obstetrics and Gynecology core clerkship. His research centered on surgical education and the prevention of postoperative urinary tract infections. He was a co-investigator in the NIH Pelvic Floor Disease Network. He contributed to the establishment of the Nazarbayev School of Medicine in Astana Kazakhstan.

Dr. Sutkin’s research interests center on surgical safety and error prevention. He is interested in how communication between attending and resident surgeons impact patient outcome. He collaborates with a cognitive psychologist and members of the Department of Civil and Mechanical Engineering.

He is a practicing Urogynecologist and specializes in women with pelvic floor prolapse. He provides both reconstructive pelvic surgery and non-surgical treatments for women with pelvic organ prolapse, urinary incontinence, and other pelvic floor disorders.

Dr. Sutkin was born in San Antonio and grew up in Richardson, Texas. He attended Northwestern University’s Honors Program in Medical Education, worked at the federal Reserve bank in Chicago, and attained his BS, MD, and MBA degrees at Northwestern. He is an avid Northwestern fan.

Awards
  • Association of Professors of Gynecology and Obstetrics Teaching Award – 2002
  • Association of Professors of Gynecology and Obstetrics/Solvay Scholar – 2002-2003
  • Alpha Omega Alpha Society – 2003
  • Texas Tech University Health Sciences Center Dean’s Clinical Science Teaching Award – 2006
  • Council on Resident Education in Obstetrics and Gynecology Teaching Award – 2011
  • Residency Program Top 10% Golden Apple Teaching Award – 2011
  • Appointment to University of Pittsburgh School of Medicine Academy of Master Educators – 2012
  • Finalist, Patil Teaching Innovation Award – 2015
Research Interests
  • Surgical error prevention and communication
  • Intraoperative teaching
  • Midurethral sling surgery
  • Postoperative Urinary tract infections
Selected Publications
  1. Sutkin G, Littleton E, Kanter S. Intelligent cooperation: A framework of pedagogic practice in the operating room. Am J Surg. 2017 Publication Pending
  2. Oliphant S, Littleton E, Gosman G, Sutkin, G. Teaching the Retropubic Midurethral Sling  Using a Novel Cadaver and Model-Based Approach. Cureus. 2017; 9(5): e1214. DOI 10.7759/cureus.1214. PMID:PMC5453826.
  3. Paradis E, Sutkin G. Beyond a Good Story: From Hawthorne Effect to Reactivity in Health Professions Education Research. Medical Education. 2016 PMID: 27580703.
  4. Markland AD, Jelovsek E, Whitehead WE, Andy UU, Newman DK, Dyer K, Harm-Ernandes I, Cichowski S, McCormick J, Rardin C, Sutkin G, Shaffer A, Meikle S. Implementation of a Multi-site Manometric Biofeedback Intervention with Anorectal Manometry for the Treatment of Fecal Incontinence in Women. Neurogastroenterology and Motility. 2016 PMID: 27453154.
  5. Lowder J, Oliphant S, Shepherd J, Ghetti C, Sutkin G. Genital Hiatus Size is Associated with and Predictive of Apical Vaginal Support Loss. Am J Obstetrics Gynecology. 2015; PMID: 26719211
  6. J. Eric Jelovsek, Alayne D. Markland , William E. Whitehead, Matthew D. Barbe, Diane K. Newman, Rebecca G. Rogers, Keisha Dyer, Anthony Visco, Vivian W. Sung MD, Sutkin G, Susan F. Meikle Marie G. Gantz. Controlling anal incontinence by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods. Contemp Clin Trials. 2015;44, 164-74. PMID: 26291917
  7. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 2: Physical teaching guidance. Journal of Surgical Education. 2015; 72(2), 251-7. PMID: 25468768
  8. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 1: Verbal teaching guidance. Journal of Surgical Education. 2015;72(2), 243-50. PMID: 25456208
  9. Zimmern P, Litman HJ, Nager CW, Lemack GE, Richter HE, Sirls L, Kraus SR, Sutkin G, Mueller ER. Effect of aging on storage and voiding function in women with stress-predominant urinary incontinence. J Urol. 2014 Feb 8. pii: S0022-5347(14)00131-1. doi: 10.1016/j.juro.2014.01.092. PMID: 24518790.
  10. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013;2013:926313.  doi: 10.1155/2013/926313. Epub 2013 Sep 8. PMID: 24194763; PMCID: PMC3782123.
  11. Sutkin G, Dzialowski K. A gynaecologic clinic dedicated to student teaching. Clin Teach. 2013 Jun;10(3):181-5. doi: 10.1111/j.1743-498X.2012.00633.x. PMID: 23656681
  12. Nager CW, Brubaker L, Litman HJ, Zyczynski HM, Varner RE, Amundsen C, Sirls LT, Norton PA, Arisco AM, Chai TC, Zimmern P, Barber MD, Dandreo KJ, Menefee SA, Kenton K, Lowder J, Richter HE, Khandwala S, Nygaard I, Kraus SR, Johnson HW, Lemack GE, Mihova M, Albo ME, Mueller E, Sutkin G, Wilson TS, Hsu Y, Rozanski TA, Rickey LM, Rahn D, Tennstedt S, Kusek JW, Gormley EA; Urinary Incontinence Treatment Network. A randomized trial of urodynamic testing before stress-incontinence surgery. N Engl J Med. 2012 May 24;366(21):1987-97. doi: 10.1056/NEJMoa1113595. Epub 2012 May 2. PMID: 22551104; PMCID: PMC3386296
  13. Skoczylas LC, Littleton EB, Kanter SL, Sutkin G. Teaching techniques in the operating room: the importance of perceptual motor teaching. Acad Med. 2012 Mar;87(3):364-71. doi: 10.1097/ACM.0b013e31824484a0. PMID: 22373633.
  14. Nygaard I, Brubaker L, Chai TC, Markland AD, Menefee SA, Sirls L, Sutkin G, Zimmern P, Arisco A, Huang L, Tennstedt S, Stoddard A. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011 Oct;22(10):1255-65. doi: 10.1007/s00192-011-1429-9. Epub 2011 May 11.  PMID: 21560012.
  15. Martirosian Smith TE, Trowbridge ER, Pastore LM, Smith SC, Brennan MC, Dooley Y, Matthews CK, Ozel B, Sutkin G, Hullfish KL. Multicenter Urogynecology Study on Education: Medical Student Educational Experiences and Knowledge Outcomes During the OBGYN Clerkship. Female Pelvic Med Reconstr Surg. 2011 Mar;17(2):100-104. PMID: 22453697.
  16. Sutkin G, Daucher J, Zyczynski H. Prolapse in the Older Woman. European Urologic Review. 2010;5:64-8.
  17. Park AJ, Barber MD, Bent AE, Dooley YT, Dancz C, Sutkin G, Jelovsek JE. Assessment of intraoperative judgment during gynecologic surgery using the Script Concordance Test. Am J Obstet Gynecol. 2010 Sep;203(3):240.e1-6. doi: 10.1016/j.ajog.2010.04.010. Epub 2010 May 21. PMID: 20494330.
  18. Nager CW, Kraus SR, Kenton K, Sirls L, Chai TC, Wai C, Sutkin G, Leng W, Litman H, Huang L, Tennstedt S, Richter HE; Urinary Incontinence Treatment Network. Urodynamics, the supine empty bladder stress test, and incontinence severity. Neurourol Urodyn. 2010 Sep;29(7):1306-11. doi: 10.1002/nau.20836. PMID: 20127832.
  19. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug;21(8):955-61. doi: 10.1007/s00192-010-1137-x. Epub 2010 Mar 31. PMID: 20354678.
  20. Sutkin G, Littlefield JH, Laube DW. Nursing staff assessment of residents’ professionalism and communication skills. Med Educ. 2009 Nov;43(11):1104. doi: 10.1111/j.1365-2923.2009.03461.x. Epub 2009 Oct 2. PMID: 19799729.
  21. Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CISC) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Aug;20(8):933-8. doi: 10.1007/s00192-009-0885-y. Epub 2009 Apr 10. PMID: 19582384.
  22. Sutkin G, Aronoff CK. Resident front office experience: a systems-based practice activity. Med Educ Online. 2008 May 28;13:6. doi: 10.3885/meo.2008.T0000120. PMID: 20165536; PMCID: PMC2779599.
  23. Sutkin G, Wagner E, Harris I, Schiffer R. What makes a good clinical teacher in medicine? A review of the literature. Acad Med. 2008 May;83(5):452-66. doi: 10.1097/ACM.0b013e31816bee61. Review. PMID: 18448899.
  24. Sutkin G, Burley H, Zhang K, Arora N. Characteristics of good clinical educators from medical students perspectives: A Qualitative inquiry using a web-based survey system. International Journal of Healthcare Information Systems and Informatics. 2008;3(2):69-86.
  25. Sutkin G, Krohn MA, Heine RP, Sweet RL. Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. Obstet Gynecol. 2005 Mar;105(3):581-6. PMID: 15738028.
  26. Sutkin G, Mamlok V. Images in clinical medicine. Fetus papyraceus. N Engl J Med. 2004 Apr 15;350(16):1665. PMID: 15084699.

Complete list of publications


Photo of John Qiang Wang, M.D., Ph.D.
John Qiang Wang, M.D., Ph.D.
Acting Associate Dean for Research and Professor Departments of Anesthesiology & Biomedical Sciences Work M3-225 Work Phone: (816) 235-1907
  • Westport Anesthesia / Missouri Endowed Chair for Research
  • M.D. Degree: Tongji Medical University, Wuhan, China
  • MS Degree: Tongi Medical University, Wuhan, China
  • Ph.D, Degree: Shanghai Medical University, Shanghai China
  • Fellowship: Beijing Medical University, Beijing China
  • Fellowship: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
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Biography

John Q. Wang is a Westport Anesthesia/Missouri Endowed Chair in the Department of Anesthesiology and a Professor in the Departments of Anesthesiology and Basic Medical Science at UMKC School of Medicine since 2004. He earned his medical degree in Tongji Medical University in 1982 and his Ph.D. in Shanghai Medical University in 1988. Dr. Wang’s research primarily focuses on drug abuse and addiction. He currently leads a research team supported by NIH grants to conduct animal experiments from molecule to behavior and from in vitro to in vivo. In addition, Dr. Wang is interested in elucidating molecular mechanisms for anesthesia induction.

 

Selected Publications

Mao LM, Fibuch EE and Wang JQ. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron. 67: 679-681.

Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM and Wang JQ. (2010). CaMKIIα interacts with M4 muscarinic receptors to control receptor and psychomotor function. EMBO J. 29: 2070-2081.

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ and Buch S. (2010). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115: 4951-4962.

Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ. Fibuch EE, Buch S, Chen JG, Wang JQ. (2009). Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12:602-610. PMC2749993.

Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M and Wang JQ. (2009). Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 61:425-438. PMC2650276.

Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG and Wang JQ. (2006). Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 52:897-909.

Yang L, Mao L, Chen H, Catavsan M, Kozinn J, Arora A, Liu X and Wang JQ. (2006). A signaling mechanism from Gαq-protein-coupled glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J Neurosci. 26: 971-980.

Mao L, Yang L, Tang Q, Samdani S, Zhang G and Wang JQ. (2005). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 25: 2741-2752.

Yang L, Mao L, Tang Q, Samdani S, Liu Z and Wang JQ. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 24: 10846-10857.

Biochemistry & Cell Biology

Biochemistry

Affiliated Faculty

Photo of Charles S. Barnes, Ph.D.
Charles S. Barnes, Ph.D.
Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Fu-Sheng Chou, M.D., Ph.D.
Fu-Sheng Chou, M.D., Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics


Photo of Mingui Fu, Ph.D.
Mingui Fu, Ph.D.
Associate Professor Immunology, Shock/Trauma Research CenterBiomedical Sciences Work MG-101A Work Phone: (816) 235-2193
  • M.S.:   Xian Medical University, China, 1994
  • Ph.D.:   Peking University Health Science Center, China, 2000
  • Postdoctoral Fellow: Morehouse School of Medicine, Atlanta, 2003 and UT Southwestern Medical Center, Dallas, 2006
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Research Area:

Molecular Insights in Inflammation and Inflammatory Diseases

Topics of Interest:
  • Regulatory mechanisms of septic shock
  • Signal transduction in macrophage activation
  • RNA metabolism in immune regulation
  • Negative regulation of Toll-like receptor signaling
  • Molecular signaling of vascular endothelial inflammation, injury and repair
  • Novel therapeutic targets for human inflammatory diseases including atherosclerosis, sepsis and viral infection
Recent Projects:
  1. The Roles of CCCH-Zinc Finger Proteins in the Regulation of Inflammation.
         Nearly 60 CCCH-zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation, and decay. Several CCCH-zinc finger proteins, such as tristetraprolin, Roquin and MCPIP1, are crucial for many aspects of immune responses via targeting mRNA degradation and other mechanisms. Others are involved in the regulation of cell differentiation and cancer cell growth. In the past ten years, we have been working on a novel CCCH-zinc finger containing protein, MCPIP1, in the regulation of both innate and adaptive immunity. Using transgenic and knockout mouse models, we are studying the physiological role and mechanisms of MCPIP1 in inflammatory response and immunity and the involvement of MCPIP1 in septic shock, atherosclerosis and autoimmune diseases.
  2. Novel Molecular Regulators in Vascular Endothelial Inflammation, Injury and Repair.
         Vascular endothelium is a multifunctional and critical interface between blood stream and vascular wall. Meanwhile, vascular endothelium is also the largest endocrine, paracrine and metabolic organ. Recent studies suggest that there is endothelial dysfunction at the early stage of cardiovascular diseases and stroke caused by atherosclerosis, hypertension and diabetes. In addition, the initial event in bacterial and viral infection-caused multi-organ injury is vascular endothelial damage and dysfunction. So that vascular endothelial inflammation and dysfunction is a common pathological step and basis for cardiovascular diseases and stroke and acute organ injury. Improving the function of vascular endothelium and repairing the damaged vascular endothelium would be a critical step for treatment of cardiovascular diseases and stroke and acute organ injury. Using expression profiling and bioinformatics, we recently identified an adipocyte-enriched protein, adiporedoxin, as a negative regulator of endothelial activation (Sci Rep, 2016). In addition, we have identified a TRIM protein as a novel determinant of vascular endothelial inflammation via targeting VCAM-1 degradation. Currently, we are studying the roles and mechanisms of these proteins in vascular inflammation, atherosclerosis, sepsis and cerebral small vascular disease.
Selected Publications:
  1. Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M#. A novel CCCH-Zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem. 2008, 283:6337-6346.
  2. Liang J, Lei T, Song Y, Yanes N and Fu M#. RNA-destabilizing factor Tristetraprolin negatively regulates NF-κB signaling. J Biol Chem. 2009, 284: 29383-29390.
  3. Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, Kolattukudy PE and Fu M#. MCP-induced protein 1 deubiquitinating TRAFs and negatively regulate JNK and NF-κB signaling. J Exp Med, 2010, 207:2959-73.
  4. Qi D, Huang S, Miao R, She ZG, Quinn T, Chang Y, Liu J, Fan D, Chen YE, Fu M#. Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress. J Biol Chem. 2011, 286(48):41692-700.
  5. Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom AR, Kliewer SA, Mangelsdorf DJ, Schulman IG. Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest, 2012, 122(5):1688-99.
  6. Zhang J, Zhang Y, Sun T, Chandalia M, Abate N, Fan D, Xin HB, Chen YE# and Fu M#. Dietary obesity induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2. Sci Rep. 2013, 3:1476.
  7. Niu J, Shi Y, Xue J, Xu M, Miao R, Huang S, Chen ZJ, Fu M, Wu Z-H. DNA damage-induced MCPIP1 negatively regulates NF-κB activation by facilitating USP10-dependent disassembly of linear polyubiquitin chain. EMBO J, 2013, 32:3206-3219.
  8. Liu S, Qiu C, Miao R, Zhou J, Fu W, Zhu L, Zhang L, Xu J, Fan D, Li K, Fu M#, Wang T#. MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells. Proc Natl Acad Sci U S A., 2013, 110(47):19083-8.
  9. Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K, Fu M, Hu G, Kolattukudy P, Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun. 2014. 5:4386.
  10. Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M & Heissmeyer V. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation. Nat Immunol. 2014, 15(11):1079-1089.
  11. Huang S, Liu S, Fu JJ, Tony Wang T, Yao X, Kumar A, Liu G, Fu M#. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. J Biol Chem. 2015 Aug 21;290(34):20782-92.
  12. He H, Guo F, Li Y, Saaoud F, Kimmis BD, Sandhu J, Fan M, Maulik D, Lessner S, Fan D, Jiang ZS#, and Fu M#. Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling. Sci Rep. 2016 (in press).
  13. Jiang MX, Hong X, Liao BB, Shi SZ, Lai XF, Zheng HY, Xie L, Wang Y, Wang XL, Xin HB, Fu M#, and Deng KY#. Expression profiling identifies a novel group of TRIM proteins involving in the proinflammatory activation of macrophages. Sci Rep. 2016 (in press).


Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

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Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
  • Research Interests: Next generation DNA sequencing, Translational Bioinformatics and integrative strategy of animal model, biochemical, cellular, molecular and omic approaches to identify new diagnostic biomarkers and novel therapeutic targets to complex human diseases such as acute respiratory distress syndrome, coronary heart disease, chronic kidney disease and drug induced liver injury.

Photo of Nilofer Qureshi, Ph.D.
Nilofer Qureshi, Ph.D.
Director – Molecular & Cellular Immunology, Professor Immunology Work MG-CO5E Home Phone: (816) 235-1965
  • Ph. D. in Physiological Chemistry, Medical School, University of Wisconsin, Madison, WI
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Research Interests:

To develop novel therapeutic approaches to treat septic shock and inflammation.

We were the first to establish the complete structure of the lipid A moiety of the enterobacterial lipopolysaccharide (LPS), developed monophosphoryl lipid A as an effective adjuvant and Rhodobacter sphaeroides diphosphoryl lipid A as a powerful LPS antagonist in both in vitro and in vivo systems. Our recent research centers on the biology of LPS, especially, with regards to its effect on the ubiquitin-proteasome pathway (UPP) in macrophages and septic shock. We initially demonstrated that the LPS-induced cytokines are dependent on the composition of proteasome’s subunits present in the macrophages. We are working on a novel therapeutic approach for septic shock based upon proteasome inhibitors and antibiotics. We are also establishing the identity of ubiquitinated proteins in the LPS-induced signal transduction that are degraded by the proteasome in murine macrophages and human cells. Our conclusion from these studies is that the proteasome is a central regulator of macrophage function and inflammation and is involved in several diseases such as septic shock, cardiovascular problems, cancer and asthma.

 

Selected Publications : out of a total of over 130

Qureshi N, Perera P-Y, Shen J, Zhang G, Lenschat A, Spptter G, Morrison DC, Vogel SN. The proteasome as a LPS-binding protein in macrophages: Differential effects of proteasome inhibition on LPS-induced events. J Immunol. 2003, 171:1515-1525.

Qureshi N, Vogel SN, Van Way III, Papasian C, Qureshi AA, Morrison DC. The proteasome, a central regulator of Inflammation and macrophage function. Immunologic Research 2005, 31/3:243-260.

Shen J, Reis J, Morrison DC, Papasian C, Sreekumar R, Kolbert C, Qureshi AA, Vogel SN and Qureshi N: Key Inflammatory signapng pathways are regulated by the proteasome. Shock 2006, 25:472-484.

Reis J, Guan X-Q, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, Van Way C III, Vogel SN, and Qureshi N. LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochemistry and Biophysics (in press 2010).

Reis J, Hassan F, Guan X-Q, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way C III, Vogel SN, Morrison DC, and Qureshi N. LMP Subunits of the proteasomes regulate the TRIF/TRAM pathway. Cell Biochemistry and Biophysics (in press 2010).


Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Tarak Srivastava, M.D.
Tarak Srivastava, M.D.
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Michael Wacker, Ph.D.
Michael Wacker, Ph.D.
Assistant Dean of Medical Student Research Associate Teaching Professor, Vice-chair Biomedical SciencePhysiology, Biomedical Sciences Work Phone: (816) 235-6069
  • University of Kansas – Ph.D. (2003)
  • Texas Christian University – B.S. (1997)
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Biography

Dr. Wacker joined the Department of Basic Medical Science in the School of Medicine in 2007. He currently teaches physiology in the Human Structure Function series taught to the medical school students, as well as physiology courses in the Anesthesiologist Assistant program and the Physician Assistant program. Dr. Wacker is a member of the Muscle Biology Group at UMKC with expertise in cardiac muscle physiology. The interests in his laboratory focus on agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. Acutely, changes in calcium homeostasis can lead to arrhythmias and alteration of cardiac muscle contractility. More chronic alterations in calcium, however, can lead to remodeling of the heart as observed in cardiac hypertrophy and heart failure. Specifically, Dr. Wacker is interested in endocrine/paracrine agents which may directly alter calcium changes in cardiac myocytes via signaling mediated by membrane receptors. Recently, Dr. Wacker and the Muscle Biology Group have worked in collaboration with the UMKC Bone Biology Group on a NIH-funded project exploring mechanisms of bone-muscle crosstalk. Dr. Wacker’s laboratory has concentrated on a hormone, FGF23, released by bone cells that may play a role in directly altering cardiac function during chronic kidney disease. Additional interests in the laboratory focus on how thromboxane A2, intracellular phosphoinositide signaling, and fibrate drugs may directly alter cardiac muscle function.

 

Recent Publications

Gallagher PM, Touchberry CD, Teson K, McCabe E, Tehel M, Wacker MJ. Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression. Applied Physiology, Nutrition, and Metabolism. 38 (5): 581-586, 2013. PMID: 23668768

Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, Girgis M, Vincent RJ, Wetmore LA, Dawn B, Bonewald L, Stubbs JR, Wacker MJ. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. American Journal of Physiology: Endocrinology and Metabolism. 304 (8): E863-873. 2013. PMID: 23443925

Bonewald LF, Wacker MJ. FGF23 Production by Osteocytes. Pediatric Nephrology. 28 (4): 563-568. 2013. PMID: 22983423

Silswal N, Parelkar NK, Wacker MJ, Badr M, Andresen J.   PPARa-Independent Arterial Smooth Muscle Relaxant Effects of PPARa Agonists. PPAR Research. 302495. 2012. PMID: 23008696

Wacker MJ, Tevis O, Hanke J, Howard T, Gilbert W, Orr JA. Characterization of thromboxane A2 receptor and TRPV1 mRNA in cultured sensory neurons. Neuroscience Letters. 515(1):12-7. 2012. PMID: 22425716

Silswal N, Parelkar N, Wacker MJ, Brotto M, Andresen J. Phosphatidylinositol 3,5-bisphosphate increases intracellular free calcium in arterial smooth muscle cells and elicits vasocontraction. American Journal of Physiology: Heart and Circulatory Physiology. 300 (6): H2016-26. 2011. PMID: 21421826

Touchberry CD, Elmore CJ, Nguyen TM, Andresen JJ, Zhao X, Orange M, Weisleder N, Brotto M, Claycomb WC, Wacker MJ. Store-Operated Calcium Entry is Present in HL-1 Cardiomyocytes and Contributes to Resting Calcium. Biochemical and Biophysical Research Communications. 416 (1-2): 45-50. 2011. PMID: 22079292

Touchberry CD, Bales IK, Stone JK, Rohrberg TJ, Parelkar NK, Nguyen T, Fuentes O, Liu X, Qu CK, Andresen JJ, Valdivia HH, Brotto M, Wacker MJ. Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility Via Activation of the Ryanodine Receptor. Journal of Biological Chemistry. 285 (51): 40312-21. 2010. PMID: 20947503


Photo of John Qiang Wang, M.D., Ph.D.
John Qiang Wang, M.D., Ph.D.
Acting Associate Dean for Research and Professor Departments of Anesthesiology & Biomedical Sciences Work M3-225 Work Phone: (816) 235-1907
  • Westport Anesthesia / Missouri Endowed Chair for Research
  • M.D. Degree: Tongji Medical University, Wuhan, China
  • MS Degree: Tongi Medical University, Wuhan, China
  • Ph.D, Degree: Shanghai Medical University, Shanghai China
  • Fellowship: Beijing Medical University, Beijing China
  • Fellowship: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
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Biography

John Q. Wang is a Westport Anesthesia/Missouri Endowed Chair in the Department of Anesthesiology and a Professor in the Departments of Anesthesiology and Basic Medical Science at UMKC School of Medicine since 2004. He earned his medical degree in Tongji Medical University in 1982 and his Ph.D. in Shanghai Medical University in 1988. Dr. Wang’s research primarily focuses on drug abuse and addiction. He currently leads a research team supported by NIH grants to conduct animal experiments from molecule to behavior and from in vitro to in vivo. In addition, Dr. Wang is interested in elucidating molecular mechanisms for anesthesia induction.

 

Selected Publications

Mao LM, Fibuch EE and Wang JQ. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron. 67: 679-681.

Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM and Wang JQ. (2010). CaMKIIα interacts with M4 muscarinic receptors to control receptor and psychomotor function. EMBO J. 29: 2070-2081.

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ and Buch S. (2010). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115: 4951-4962.

Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ. Fibuch EE, Buch S, Chen JG, Wang JQ. (2009). Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12:602-610. PMC2749993.

Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M and Wang JQ. (2009). Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 61:425-438. PMC2650276.

Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG and Wang JQ. (2006). Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 52:897-909.

Yang L, Mao L, Chen H, Catavsan M, Kozinn J, Arora A, Liu X and Wang JQ. (2006). A signaling mechanism from Gαq-protein-coupled glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J Neurosci. 26: 971-980.

Mao L, Yang L, Tang Q, Samdani S, Zhang G and Wang JQ. (2005). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 25: 2741-2752.

Yang L, Mao L, Tang Q, Samdani S, Liu Z and Wang JQ. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 24: 10846-10857.

Biomedical & Health Informatics

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Biomedical and Health Informatics

Affiliated Faculty

Photo of Thomas M. Attard, M.D.
Thomas M. Attard, M.D.
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics


Photo of Mary M. Gerkovich, Ph.D.
Mary M. Gerkovich, Ph.D.
Associate Professor Office for Health Services & Outcomes ResearchDepartment of Biomedical & Health Informatics
  • 1998 – University of Kansas
  • Research interests: Factors related to the decisions people make about health practices including predictors of both maintaining positive health behaviors and changing unhealthy behaviors; factors that predict risk behavior; and analysis of multidimensional health behavior data sets.

Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
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Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

The integration of genomic information with electronic health records, genomic clinical decision support, the use of informatics to accelerate research and the analysis of large de-identified clinical data sets to reach new insights.

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Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

More info

Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital

Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Mark Patterson, Ph.D., M.P.H.
Associate Professor UMKC School of Pharmacy

Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
  • Research Interests: Next generation DNA sequencing, Translational Bioinformatics and integrative strategy of animal model, biochemical, cellular, molecular and omic approaches to identify new diagnostic biomarkers and novel therapeutic targets to complex human diseases such as acute respiratory distress syndrome, coronary heart disease, chronic kidney disease and drug induced liver injury.

Photo of Nilofer Qureshi, Ph.D.
Nilofer Qureshi, Ph.D.
Director – Molecular & Cellular Immunology, Professor Immunology Work MG-CO5E Home Phone: (816) 235-1965
  • Ph. D. in Physiological Chemistry, Medical School, University of Wisconsin, Madison, WI
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Research Interests:

To develop novel therapeutic approaches to treat septic shock and inflammation.

We were the first to establish the complete structure of the lipid A moiety of the enterobacterial lipopolysaccharide (LPS), developed monophosphoryl lipid A as an effective adjuvant and Rhodobacter sphaeroides diphosphoryl lipid A as a powerful LPS antagonist in both in vitro and in vivo systems. Our recent research centers on the biology of LPS, especially, with regards to its effect on the ubiquitin-proteasome pathway (UPP) in macrophages and septic shock. We initially demonstrated that the LPS-induced cytokines are dependent on the composition of proteasome’s subunits present in the macrophages. We are working on a novel therapeutic approach for septic shock based upon proteasome inhibitors and antibiotics. We are also establishing the identity of ubiquitinated proteins in the LPS-induced signal transduction that are degraded by the proteasome in murine macrophages and human cells. Our conclusion from these studies is that the proteasome is a central regulator of macrophage function and inflammation and is involved in several diseases such as septic shock, cardiovascular problems, cancer and asthma.

 

Selected Publications : out of a total of over 130

Qureshi N, Perera P-Y, Shen J, Zhang G, Lenschat A, Spptter G, Morrison DC, Vogel SN. The proteasome as a LPS-binding protein in macrophages: Differential effects of proteasome inhibition on LPS-induced events. J Immunol. 2003, 171:1515-1525.

Qureshi N, Vogel SN, Van Way III, Papasian C, Qureshi AA, Morrison DC. The proteasome, a central regulator of Inflammation and macrophage function. Immunologic Research 2005, 31/3:243-260.

Shen J, Reis J, Morrison DC, Papasian C, Sreekumar R, Kolbert C, Qureshi AA, Vogel SN and Qureshi N: Key Inflammatory signapng pathways are regulated by the proteasome. Shock 2006, 25:472-484.

Reis J, Guan X-Q, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, Van Way C III, Vogel SN, and Qureshi N. LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochemistry and Biophysics (in press 2010).

Reis J, Hassan F, Guan X-Q, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way C III, Vogel SN, Morrison DC, and Qureshi N. LMP Subunits of the proteasomes regulate the TRIF/TRAM pathway. Cell Biochemistry and Biophysics (in press 2010).


Photo of Steve Simon, Ph.D.
Steve Simon, Ph.D.
Research Professor Department of Biomedical & Health Informatics
  • 1982 -University of Iowa
  • Research interests: Accrual problems in clinical trials, information theory, monitoring adverse events in clinical trials, research ethics and risk adjustment models.

Photo of Kim Smolderen, Ph.D.
Kim Smolderen, Ph.D.
Assistant Professor — Implementation Science Department of Biomedical & Health Informatics
  • 2012, Post-Doctoral Fellowship in Outcomes Research PRT: American Heart Association, St. Luke’s Mid-America Heart Institute
  • 2009, PhD in Medical Psychology, Tilburg University, Tilburg Netherlands
  • Research Interests: Identification of subpopulations at-risk of suboptimal health status and clinical outcomes in cardiac populations, with focus on patients with peripheral arterial disease (PAD).

Cardiology

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Cardiology

Affiliated Faculty

Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

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Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Kim Smolderen, Ph.D.
Kim Smolderen, Ph.D.
Assistant Professor — Implementation Science Department of Biomedical & Health Informatics
  • 2012, Post-Doctoral Fellowship in Outcomes Research PRT: American Heart Association, St. Luke’s Mid-America Heart Institute
  • 2009, PhD in Medical Psychology, Tilburg University, Tilburg Netherlands
  • Research Interests: Identification of subpopulations at-risk of suboptimal health status and clinical outcomes in cardiac populations, with focus on patients with peripheral arterial disease (PAD).

Photo of Michael Wacker, Ph.D.
Michael Wacker, Ph.D.
Assistant Dean of Medical Student Research Associate Teaching Professor, Vice-chair Biomedical SciencePhysiology, Biomedical Sciences Work Phone: (816) 235-6069
  • University of Kansas – Ph.D. (2003)
  • Texas Christian University – B.S. (1997)
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Biography

Dr. Wacker joined the Department of Basic Medical Science in the School of Medicine in 2007. He currently teaches physiology in the Human Structure Function series taught to the medical school students, as well as physiology courses in the Anesthesiologist Assistant program and the Physician Assistant program. Dr. Wacker is a member of the Muscle Biology Group at UMKC with expertise in cardiac muscle physiology. The interests in his laboratory focus on agents that alter cardiac muscle function and calcium homeostasis in cardiac myocytes. Acutely, changes in calcium homeostasis can lead to arrhythmias and alteration of cardiac muscle contractility. More chronic alterations in calcium, however, can lead to remodeling of the heart as observed in cardiac hypertrophy and heart failure. Specifically, Dr. Wacker is interested in endocrine/paracrine agents which may directly alter calcium changes in cardiac myocytes via signaling mediated by membrane receptors. Recently, Dr. Wacker and the Muscle Biology Group have worked in collaboration with the UMKC Bone Biology Group on a NIH-funded project exploring mechanisms of bone-muscle crosstalk. Dr. Wacker’s laboratory has concentrated on a hormone, FGF23, released by bone cells that may play a role in directly altering cardiac function during chronic kidney disease. Additional interests in the laboratory focus on how thromboxane A2, intracellular phosphoinositide signaling, and fibrate drugs may directly alter cardiac muscle function.

 

Recent Publications

Gallagher PM, Touchberry CD, Teson K, McCabe E, Tehel M, Wacker MJ. Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression. Applied Physiology, Nutrition, and Metabolism. 38 (5): 581-586, 2013. PMID: 23668768

Touchberry CD, Green TM, Tchikrizov V, Mannix JE, Mao TF, Carney BW, Girgis M, Vincent RJ, Wetmore LA, Dawn B, Bonewald L, Stubbs JR, Wacker MJ. FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. American Journal of Physiology: Endocrinology and Metabolism. 304 (8): E863-873. 2013. PMID: 23443925

Bonewald LF, Wacker MJ. FGF23 Production by Osteocytes. Pediatric Nephrology. 28 (4): 563-568. 2013. PMID: 22983423

Silswal N, Parelkar NK, Wacker MJ, Badr M, Andresen J.   PPARa-Independent Arterial Smooth Muscle Relaxant Effects of PPARa Agonists. PPAR Research. 302495. 2012. PMID: 23008696

Wacker MJ, Tevis O, Hanke J, Howard T, Gilbert W, Orr JA. Characterization of thromboxane A2 receptor and TRPV1 mRNA in cultured sensory neurons. Neuroscience Letters. 515(1):12-7. 2012. PMID: 22425716

Silswal N, Parelkar N, Wacker MJ, Brotto M, Andresen J. Phosphatidylinositol 3,5-bisphosphate increases intracellular free calcium in arterial smooth muscle cells and elicits vasocontraction. American Journal of Physiology: Heart and Circulatory Physiology. 300 (6): H2016-26. 2011. PMID: 21421826

Touchberry CD, Elmore CJ, Nguyen TM, Andresen JJ, Zhao X, Orange M, Weisleder N, Brotto M, Claycomb WC, Wacker MJ. Store-Operated Calcium Entry is Present in HL-1 Cardiomyocytes and Contributes to Resting Calcium. Biochemical and Biophysical Research Communications. 416 (1-2): 45-50. 2011. PMID: 22079292

Touchberry CD, Bales IK, Stone JK, Rohrberg TJ, Parelkar NK, Nguyen T, Fuentes O, Liu X, Qu CK, Andresen JJ, Valdivia HH, Brotto M, Wacker MJ. Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility Via Activation of the Ryanodine Receptor. Journal of Biological Chemistry. 285 (51): 40312-21. 2010. PMID: 20947503


Photo of John Qiang Wang, M.D., Ph.D.
John Qiang Wang, M.D., Ph.D.
Acting Associate Dean for Research and Professor Departments of Anesthesiology & Biomedical Sciences Work M3-225 Work Phone: (816) 235-1907
  • Westport Anesthesia / Missouri Endowed Chair for Research
  • M.D. Degree: Tongji Medical University, Wuhan, China
  • MS Degree: Tongi Medical University, Wuhan, China
  • Ph.D, Degree: Shanghai Medical University, Shanghai China
  • Fellowship: Beijing Medical University, Beijing China
  • Fellowship: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
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Biography

John Q. Wang is a Westport Anesthesia/Missouri Endowed Chair in the Department of Anesthesiology and a Professor in the Departments of Anesthesiology and Basic Medical Science at UMKC School of Medicine since 2004. He earned his medical degree in Tongji Medical University in 1982 and his Ph.D. in Shanghai Medical University in 1988. Dr. Wang’s research primarily focuses on drug abuse and addiction. He currently leads a research team supported by NIH grants to conduct animal experiments from molecule to behavior and from in vitro to in vivo. In addition, Dr. Wang is interested in elucidating molecular mechanisms for anesthesia induction.

 

Selected Publications

Mao LM, Fibuch EE and Wang JQ. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron. 67: 679-681.

Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM and Wang JQ. (2010). CaMKIIα interacts with M4 muscarinic receptors to control receptor and psychomotor function. EMBO J. 29: 2070-2081.

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ and Buch S. (2010). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115: 4951-4962.

Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ. Fibuch EE, Buch S, Chen JG, Wang JQ. (2009). Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12:602-610. PMC2749993.

Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M and Wang JQ. (2009). Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 61:425-438. PMC2650276.

Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG and Wang JQ. (2006). Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 52:897-909.

Yang L, Mao L, Chen H, Catavsan M, Kozinn J, Arora A, Liu X and Wang JQ. (2006). A signaling mechanism from Gαq-protein-coupled glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J Neurosci. 26: 971-980.

Mao L, Yang L, Tang Q, Samdani S, Zhang G and Wang JQ. (2005). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 25: 2741-2752.

Yang L, Mao L, Tang Q, Samdani S, Liu Z and Wang JQ. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 24: 10846-10857.

Community & Family Medicine

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Community and Family Medicine

Affiliated Faculty

Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

More info

Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Paula Monaghan-Nichols, Ph.D.
Paula Monaghan-Nichols, Ph.D.
Associate Dean for Research, Chair and Professor Biomedical Sciences Biomedical Sciences Home M3-C02 Work Phone: (816) 235-6663
  • Trinity College, Dublin, Ireland, BA (Genetics)
  • Medical Research Council, Edinburgh, Scotland, Ph.D. (Genetic Engineering and Molecular Biology)
  • Medical Research Council, Human Genetics Unit, Edinburgh, Scotland, Post-Graduate (Molecular Genetics and Development)
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Research and Professional Experience

Postdoctoral Fellow/Research Associate, Molecular Biology of the Cell 1, German Cancer Research Centre, Heidelberg, Germany.

Assistant Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

 Associate Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Research Interest

Molecular Genetic Analysis of the Developmental Basis of Neuropsychiatric Disorders

Research Summary

My laboratory focuses on understanding the molecular and developmental basis of emotional and cognitive behavior and psychiatric illness. The long-term goal of my research is to identify both intrinsic and environmental factors that specifically alter the development of areas in the brain that are essential for emotion and cognition.  My laboratory has identified a number of transcriptional repressors (Tlx, Sall1, Sall2, Sall3 and Sall4) that are expressed in the developing forebrain. This research has shown that these genes are express in stem and progenitor cells in the cerebral cortex, and are required to regulate the rate of stem/progenitor cell proliferation and neuronal differentiation.  Using both conditional and classical knockout experiments and in-utero electroporation studies in mice, my laboratory has shown that altering the levels of these proteins during development leads to emotional, behavioral and cognitive abnormalities in adult animals.  Our most recent studies focus on identifying the cellular and biochemical targets of glucocorticoid action on the developing brain in-utero. Synthetic glucocorticoids are administered to mothers at risk for pre-term labor, to stimulate lung maturation and to reduce the risk of intraventricular hemorrhage and necrotizing enterocolitis. Clinical follow up studies indicate that children exposed to steroid in-utero have cognitive abnormalities and an altered stress response. My laboratory is using a combination of molecular, cellular, proteomic, RNA-Seq. and genome wide DNase hypersensitive site mapping to identify the cellular targets of steroid action. These studies have shown that prenatal exposure to glucocorticoids leads to changes in neuronal number and density in the cerebral cortex at birth coupled to long-term alterations in neurite complexity in the prefrontal cortex and hippocampus in adolescents. These anatomical abnormalities are associated with changes in anxiety and depressive like behaviors in adults. Follow up studies include validating our identified targets in human brain and in umbilical cord blood cells.  These findings will for a framework for modifying current clinical dosing regiments in preterm labor to reduce the adverse consequences of premature exposure to corticosteroids in-utero.

Selected Publications

Research Resource: The Dexamethasone Transcriptome in Hypothalamic Embryonic Neural Stem Cells.Frahm KA, Peffer ME, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan AP, DeFranco DB. Mol Endocrinol. 2016 Jan;30(1):144-54.

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.Kim SW, Fishilevich E, Arango-Argoty G, Lin Y, Liu G, Li Z, Monaghan AP, Nichols M, John B. PLoS One. 2015 Mar 23;10(3):e0120296..

Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells.Peffer ME, Chandran UR, Luthra S, Volonte D, Galbiati F, Garabedian MJ, Monaghan AP, DeFranco DB. Mol Cell Biol. 2014 Jul;34(14):2611-23.

Wu P1, Teot L, Murdoch GH, Monaghan-Nichols P, McFadden K.  Neuropathology of 22q11 Deletion Syndrome in an Infant. Pediatr Dev Pathol. 2014 17(5):386-92.

An in-depth map of polyadenylation sites in cancer. Lin Y, Li Z, Ozsolak F, Kim SW, Arango-Argoty G, Liu TT, Tenenbaum SA, Bailey T, Monaghan AP, Milos PM, John B. Nucleic Acids Res. 2012 Sep 1;40(17):8460-71.

Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Harrison SJ, Nishinakamura R, Jones KR, Monaghan AP. Dis Model Mech. 2012 May;5(3):351-65.

 Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Ozsolak F, Kapranov P, Foissac S, Kim SW, Fishilevich E, Monaghan AP, John B, Milos PM. Cell. 2010 Dec 10;143(6):1018-29. doi: 10.1016/j.cell.

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism.Kapranov P, Ozsolak F, Kim SW, Foissac S, Lipson D, Hart C, Roels S, Borel C, Antonarakis SE, Monaghan AP, John B, Milos PM. Nature. 2010 Jul 29;466(7306):642-6. doi: 10.1038/nature09190.

Sall3 is required for the terminal maturation of olfactory glomerular interneurons.Harrison SJ, Parrish M, Monaghan AP. J Comp Neurol. 2008 Apr 10;507(5):1780-94.

Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb. Harrison SJ, Nishinakamura R, Monaghan AP. Cereb Cortex. 2008 Jul;18(7):1604-17.

Abnormal development of zinc-containing cortical circuits in the absence of the transcription factor Tailless. Land PW, Monaghan AP. Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):97-101.

The Tlx gene regulates the timing of neurogenesis in the cortex. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP. J Neurosci. 2004 Sep 22;24(38):8333-45.

Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP. Mol Cell Biol. 2004 Aug;24(16):7102-12.

Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Land PW, Monaghan AP. Cereb Cortex. 2003 Sep;13(9):921-31.

Loss of the tailless gene affects forebrain development and emotional behavior. Roy K, Thiels E, Monaghan AP. Physiol Behav. 2002 Dec;77(4-5):595-600.

A new member of the spalt like zinc finger protein family, Msal-3, is expressed in the CNS and sites of epithelial/mesenchymal interaction. Ott T, Parrish M, Bond K, Schwaeger-Nickolenko A, Monaghan AP.= Mech Dev. 2001 Mar;101(1-2):203-7.

Defective limbic system in mice lacking the tailless gene. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. Nature. 1997 Dec 4;390(6659):515-7.

Emergency Medicine

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Emergency Medicine

Affiliated Faculty

Photo of P. Charles Inboriboon, M.D., FACEP
P. Charles Inboriboon, M.D., FACEP
Associate Professor – UMKC Truman Medical Center Hospital Hill; Childrens Mercy Kansas CityDepartment of Emergency Medicine
  • Dept Position:  Associate Residency Program Director
  • Undergraduate School:  University of Illinois at Chicago
  • Medical School:  University of Illinois at Chicago
  • EM Residency:  University of Illinois at Chicago
  • Fellowship:  University of Rochester (International Emergency Medicine)
  • ABEM Diplomate:  2007
  • MPH:  University of Rochester, 2010
View Bio

Dr. Inboriboon was born and raised in Chicago, IL. He completed the combined BS/MD program at the University of Illinois at Chicago. Subsequently, he completed his emergency medicine residency training at the University of Illinois at Chicago where he served as chief resident. Following residency he completed a fellowship in international emergency medicine and obtained his masters in public health at the University of Rochester. During that time, he worked abroad in Thailand, India, Haiti, Kosovo, and Nicaragua. Following completion of his fellowship he stayed on as teaching faculty until he relocated to San Diego, where his wife pursued her fellowship training in Rheumatology. In 2012, he joined the Department of Emergency Medicine at UMKC where he serves as Director of International Emergency Medicine Programs and as part of the Residency Leadership. He works clinically at both Truman Medical Center and Children’s Mercy Hospital. His academic interests include medical education and technology, international emergency medicine systems development, and global health.

Photo of Monica Gaddis, PhD
Monica Gaddis, PhD
Assistant Professor UMKC School of MedicineDepartment of Emergency Medicine
  • Dept Position:  Research Director
  • Undergraduate School: Indiana University-Bloomington
  • Graduate School:  Indiana University-Bloomington
  • Postdoctoral Fellowship: Indiana University School of Medicine, Indianapolis

Photo of Emily A, Hillman, MD
Emily A, Hillman, MD
Assistant Professor, Medical Director Simulation, UMKC Clinical Training Facility Truman Medical CentersDepartment of Emergency Medicine
  • Dept Positions:  Assistant Program Director & Student Clerkship Director
  • Undergraduate School:  University of Missouri-Kansas City
  • Medical School:  University of Missouri-Kansas City
  • EM Residency:  University of Missouri-Kansas City, Truman Medical Center
  • ABEM Diplomate:  2012
View Bio

I was born and raised in Overland Park, Kansas. I am a graduate of the UMKC 6-year combined BA/MD program. I did my residency training at UMKC/Truman Medical center and graduated in 2011. I worked for a year in community emergency medicine and I enjoyed the experience but I missed being at an academic center. I realized how much I enjoyed resident and medical student education. I became a full time faculty member with our residency program in the summer of 2012.

I am currently the assistant program director and student clerkship director. I am actively involved with our student interest group. I enjoy simulation education and I am presently involved with simulation research. I enjoy spending time with my husband, our daughter, and our 2 cocker spaniels.


Photo of Nilofer Qureshi, Ph.D.
Nilofer Qureshi, Ph.D.
Director – Molecular & Cellular Immunology, Professor Immunology Work MG-CO5E Home Phone: (816) 235-1965
  • Ph. D. in Physiological Chemistry, Medical School, University of Wisconsin, Madison, WI
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Research Interests:

To develop novel therapeutic approaches to treat septic shock and inflammation.

We were the first to establish the complete structure of the lipid A moiety of the enterobacterial lipopolysaccharide (LPS), developed monophosphoryl lipid A as an effective adjuvant and Rhodobacter sphaeroides diphosphoryl lipid A as a powerful LPS antagonist in both in vitro and in vivo systems. Our recent research centers on the biology of LPS, especially, with regards to its effect on the ubiquitin-proteasome pathway (UPP) in macrophages and septic shock. We initially demonstrated that the LPS-induced cytokines are dependent on the composition of proteasome’s subunits present in the macrophages. We are working on a novel therapeutic approach for septic shock based upon proteasome inhibitors and antibiotics. We are also establishing the identity of ubiquitinated proteins in the LPS-induced signal transduction that are degraded by the proteasome in murine macrophages and human cells. Our conclusion from these studies is that the proteasome is a central regulator of macrophage function and inflammation and is involved in several diseases such as septic shock, cardiovascular problems, cancer and asthma.

 

Selected Publications : out of a total of over 130

Qureshi N, Perera P-Y, Shen J, Zhang G, Lenschat A, Spptter G, Morrison DC, Vogel SN. The proteasome as a LPS-binding protein in macrophages: Differential effects of proteasome inhibition on LPS-induced events. J Immunol. 2003, 171:1515-1525.

Qureshi N, Vogel SN, Van Way III, Papasian C, Qureshi AA, Morrison DC. The proteasome, a central regulator of Inflammation and macrophage function. Immunologic Research 2005, 31/3:243-260.

Shen J, Reis J, Morrison DC, Papasian C, Sreekumar R, Kolbert C, Qureshi AA, Vogel SN and Qureshi N: Key Inflammatory signapng pathways are regulated by the proteasome. Shock 2006, 25:472-484.

Reis J, Guan X-Q, Kisselev AF, Papasian CJ, Qureshi AA, Morrison DC, Van Way C III, Vogel SN, and Qureshi N. LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites. Cell Biochemistry and Biophysics (in press 2010).

Reis J, Hassan F, Guan X-Q, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way C III, Vogel SN, Morrison DC, and Qureshi N. LMP Subunits of the proteasomes regulate the TRIF/TRAM pathway. Cell Biochemistry and Biophysics (in press 2010).


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
More info

Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 

Genetics & Developmental Biology

Genetics

Affiliated Faculty

Photo of Fu-Sheng Chou, M.D., Ph.D.
Fu-Sheng Chou, M.D., Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Jessica A. Hellings, M.B.B.Ch.
Professor, University of Missouri-Kansas City Center for Behavioral MedicinePsychiatry

Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education

  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials

For additional information, please click here.

 


Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Internal Medicine-Adult, Oncology, Pathology

Pathology

More Information
Affiliated Faculty

Photo of Mingui Fu, Ph.D.
Mingui Fu, Ph.D.
Associate Professor Immunology, Shock/Trauma Research CenterBiomedical Sciences Work MG-101A Work Phone: (816) 235-2193
  • M.S.:   Xian Medical University, China, 1994
  • Ph.D.:   Peking University Health Science Center, China, 2000
  • Postdoctoral Fellow: Morehouse School of Medicine, Atlanta, 2003 and UT Southwestern Medical Center, Dallas, 2006
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Research Area:

Molecular Insights in Inflammation and Inflammatory Diseases

Topics of Interest:
  • Regulatory mechanisms of septic shock
  • Signal transduction in macrophage activation
  • RNA metabolism in immune regulation
  • Negative regulation of Toll-like receptor signaling
  • Molecular signaling of vascular endothelial inflammation, injury and repair
  • Novel therapeutic targets for human inflammatory diseases including atherosclerosis, sepsis and viral infection
Recent Projects:
  1. The Roles of CCCH-Zinc Finger Proteins in the Regulation of Inflammation.
         Nearly 60 CCCH-zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation, and decay. Several CCCH-zinc finger proteins, such as tristetraprolin, Roquin and MCPIP1, are crucial for many aspects of immune responses via targeting mRNA degradation and other mechanisms. Others are involved in the regulation of cell differentiation and cancer cell growth. In the past ten years, we have been working on a novel CCCH-zinc finger containing protein, MCPIP1, in the regulation of both innate and adaptive immunity. Using transgenic and knockout mouse models, we are studying the physiological role and mechanisms of MCPIP1 in inflammatory response and immunity and the involvement of MCPIP1 in septic shock, atherosclerosis and autoimmune diseases.
  2. Novel Molecular Regulators in Vascular Endothelial Inflammation, Injury and Repair.
         Vascular endothelium is a multifunctional and critical interface between blood stream and vascular wall. Meanwhile, vascular endothelium is also the largest endocrine, paracrine and metabolic organ. Recent studies suggest that there is endothelial dysfunction at the early stage of cardiovascular diseases and stroke caused by atherosclerosis, hypertension and diabetes. In addition, the initial event in bacterial and viral infection-caused multi-organ injury is vascular endothelial damage and dysfunction. So that vascular endothelial inflammation and dysfunction is a common pathological step and basis for cardiovascular diseases and stroke and acute organ injury. Improving the function of vascular endothelium and repairing the damaged vascular endothelium would be a critical step for treatment of cardiovascular diseases and stroke and acute organ injury. Using expression profiling and bioinformatics, we recently identified an adipocyte-enriched protein, adiporedoxin, as a negative regulator of endothelial activation (Sci Rep, 2016). In addition, we have identified a TRIM protein as a novel determinant of vascular endothelial inflammation via targeting VCAM-1 degradation. Currently, we are studying the roles and mechanisms of these proteins in vascular inflammation, atherosclerosis, sepsis and cerebral small vascular disease.
Selected Publications:
  1. Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M#. A novel CCCH-Zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem. 2008, 283:6337-6346.
  2. Liang J, Lei T, Song Y, Yanes N and Fu M#. RNA-destabilizing factor Tristetraprolin negatively regulates NF-κB signaling. J Biol Chem. 2009, 284: 29383-29390.
  3. Liang J, Saad Y, Lei T, Wang J, Qi D, Yang Q, Kolattukudy PE and Fu M#. MCP-induced protein 1 deubiquitinating TRAFs and negatively regulate JNK and NF-κB signaling. J Exp Med, 2010, 207:2959-73.
  4. Qi D, Huang S, Miao R, She ZG, Quinn T, Chang Y, Liu J, Fan D, Chen YE, Fu M#. Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress. J Biol Chem. 2011, 286(48):41692-700.
  5. Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom AR, Kliewer SA, Mangelsdorf DJ, Schulman IG. Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest, 2012, 122(5):1688-99.
  6. Zhang J, Zhang Y, Sun T, Chandalia M, Abate N, Fan D, Xin HB, Chen YE# and Fu M#. Dietary obesity induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2. Sci Rep. 2013, 3:1476.
  7. Niu J, Shi Y, Xue J, Xu M, Miao R, Huang S, Chen ZJ, Fu M, Wu Z-H. DNA damage-induced MCPIP1 negatively regulates NF-κB activation by facilitating USP10-dependent disassembly of linear polyubiquitin chain. EMBO J, 2013, 32:3206-3219.
  8. Liu S, Qiu C, Miao R, Zhou J, Fu W, Zhu L, Zhang L, Xu J, Fan D, Li K, Fu M#, Wang T#. MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells. Proc Natl Acad Sci U S A., 2013, 110(47):19083-8.
  9. Yao H, Ma R, Yang L, Hu G, Chen X, Duan M, Kook Y, Niu F, Liao K, Fu M, Hu G, Kolattukudy P, Buch S. MiR-9 promotes microglial activation by targeting MCPIP1. Nat Commun. 2014. 5:4386.
  10. Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M & Heissmeyer V. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation. Nat Immunol. 2014, 15(11):1079-1089.
  11. Huang S, Liu S, Fu JJ, Tony Wang T, Yao X, Kumar A, Liu G, Fu M#. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. J Biol Chem. 2015 Aug 21;290(34):20782-92.
  12. He H, Guo F, Li Y, Saaoud F, Kimmis BD, Sandhu J, Fan M, Maulik D, Lessner S, Fan D, Jiang ZS#, and Fu M#. Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling. Sci Rep. 2016 (in press).
  13. Jiang MX, Hong X, Liao BB, Shi SZ, Lai XF, Zheng HY, Xie L, Wang Y, Wang XL, Xin HB, Fu M#, and Deng KY#. Expression profiling identifies a novel group of TRIM proteins involving in the proinflammatory activation of macrophages. Sci Rep. 2016 (in press).


Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
More info

Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

The integration of genomic information with electronic health records, genomic clinical decision support, the use of informatics to accelerate research and the analysis of large de-identified clinical data sets to reach new insights.

View CV


Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

More info

Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
More info

Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 



Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City

Medical Humanities & Bioethics

More Info

Medical Humanities and Bioethics

Affiliated Faculty

Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

More info

Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City

Photo of Gary Sutkin, M.D., M.B.A.
Gary Sutkin, M.D., M.B.A.
Professor and Program Director Associate Dean of Women’s HealthVictor and Caroline Schutte Chair in Women’s Health

Professor, Department of Biomedical and Health Informatics (Tenure) and Obstetrics and Gynecology

  • M.D. Degree: Northwestern University
  • M.B.A. Degree: J.L. Kellogg Graduate School of Management
  • Residency: Magee Womens Hospital, Pittsburgh, PA
  • Fellowship: Magee Womens Hospital, Pittsburgh, PA
  • Certification: American Board of Obstetricians and Gynecologists, Subspecialty Female Pelvic Medicine and Reconstructive Surgery
Show Bio

Biography

Gary Sutkin is the Associate Dean and Victor and Caroline Schutte Chair in Women’s Health. He is a Professor with tenure in the Department of Obstetrics and Gynecology and the Department of Biomedical and Health Informatics.

Dr. Sutkin comes to the University of Missouri Kansas City from the University of Pittsburgh. There he was in the Academy of Master Educators and directed the Obstetrics and Gynecology core clerkship. His research centered on surgical education and the prevention of postoperative urinary tract infections. He was a co-investigator in the NIH Pelvic Floor Disease Network. He contributed to the establishment of the Nazarbayev School of Medicine in Astana Kazakhstan.

Dr. Sutkin’s research interests center on surgical safety and error prevention. He is interested in how communication between attending and resident surgeons impact patient outcome. He collaborates with a cognitive psychologist and members of the Department of Civil and Mechanical Engineering.

He is a practicing Urogynecologist and specializes in women with pelvic floor prolapse. He provides both reconstructive pelvic surgery and non-surgical treatments for women with pelvic organ prolapse, urinary incontinence, and other pelvic floor disorders.

Dr. Sutkin was born in San Antonio and grew up in Richardson, Texas. He attended Northwestern University’s Honors Program in Medical Education, worked at the federal Reserve bank in Chicago, and attained his BS, MD, and MBA degrees at Northwestern. He is an avid Northwestern fan.

Awards
  • Association of Professors of Gynecology and Obstetrics Teaching Award – 2002
  • Association of Professors of Gynecology and Obstetrics/Solvay Scholar – 2002-2003
  • Alpha Omega Alpha Society – 2003
  • Texas Tech University Health Sciences Center Dean’s Clinical Science Teaching Award – 2006
  • Council on Resident Education in Obstetrics and Gynecology Teaching Award – 2011
  • Residency Program Top 10% Golden Apple Teaching Award – 2011
  • Appointment to University of Pittsburgh School of Medicine Academy of Master Educators – 2012
  • Finalist, Patil Teaching Innovation Award – 2015
Research Interests
  • Surgical error prevention and communication
  • Intraoperative teaching
  • Midurethral sling surgery
  • Postoperative Urinary tract infections
Selected Publications
  1. Sutkin G, Littleton E, Kanter S. Intelligent cooperation: A framework of pedagogic practice in the operating room. Am J Surg. 2017 Publication Pending
  2. Oliphant S, Littleton E, Gosman G, Sutkin, G. Teaching the Retropubic Midurethral Sling  Using a Novel Cadaver and Model-Based Approach. Cureus. 2017; 9(5): e1214. DOI 10.7759/cureus.1214. PMID:PMC5453826.
  3. Paradis E, Sutkin G. Beyond a Good Story: From Hawthorne Effect to Reactivity in Health Professions Education Research. Medical Education. 2016 PMID: 27580703.
  4. Markland AD, Jelovsek E, Whitehead WE, Andy UU, Newman DK, Dyer K, Harm-Ernandes I, Cichowski S, McCormick J, Rardin C, Sutkin G, Shaffer A, Meikle S. Implementation of a Multi-site Manometric Biofeedback Intervention with Anorectal Manometry for the Treatment of Fecal Incontinence in Women. Neurogastroenterology and Motility. 2016 PMID: 27453154.
  5. Lowder J, Oliphant S, Shepherd J, Ghetti C, Sutkin G. Genital Hiatus Size is Associated with and Predictive of Apical Vaginal Support Loss. Am J Obstetrics Gynecology. 2015; PMID: 26719211
  6. J. Eric Jelovsek, Alayne D. Markland , William E. Whitehead, Matthew D. Barbe, Diane K. Newman, Rebecca G. Rogers, Keisha Dyer, Anthony Visco, Vivian W. Sung MD, Sutkin G, Susan F. Meikle Marie G. Gantz. Controlling anal incontinence by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods. Contemp Clin Trials. 2015;44, 164-74. PMID: 26291917
  7. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 2: Physical teaching guidance. Journal of Surgical Education. 2015; 72(2), 251-7. PMID: 25468768
  8. Sutkin G, Littleton EB, Kanter SL. How surgical mentors teach: A classification of in vivo teaching behaviors part 1: Verbal teaching guidance. Journal of Surgical Education. 2015;72(2), 243-50. PMID: 25456208
  9. Zimmern P, Litman HJ, Nager CW, Lemack GE, Richter HE, Sirls L, Kraus SR, Sutkin G, Mueller ER. Effect of aging on storage and voiding function in women with stress-predominant urinary incontinence. J Urol. 2014 Feb 8. pii: S0022-5347(14)00131-1. doi: 10.1016/j.juro.2014.01.092. PMID: 24518790.
  10. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013;2013:926313.  doi: 10.1155/2013/926313. Epub 2013 Sep 8. PMID: 24194763; PMCID: PMC3782123.
  11. Sutkin G, Dzialowski K. A gynaecologic clinic dedicated to student teaching. Clin Teach. 2013 Jun;10(3):181-5. doi: 10.1111/j.1743-498X.2012.00633.x. PMID: 23656681
  12. Nager CW, Brubaker L, Litman HJ, Zyczynski HM, Varner RE, Amundsen C, Sirls LT, Norton PA, Arisco AM, Chai TC, Zimmern P, Barber MD, Dandreo KJ, Menefee SA, Kenton K, Lowder J, Richter HE, Khandwala S, Nygaard I, Kraus SR, Johnson HW, Lemack GE, Mihova M, Albo ME, Mueller E, Sutkin G, Wilson TS, Hsu Y, Rozanski TA, Rickey LM, Rahn D, Tennstedt S, Kusek JW, Gormley EA; Urinary Incontinence Treatment Network. A randomized trial of urodynamic testing before stress-incontinence surgery. N Engl J Med. 2012 May 24;366(21):1987-97. doi: 10.1056/NEJMoa1113595. Epub 2012 May 2. PMID: 22551104; PMCID: PMC3386296
  13. Skoczylas LC, Littleton EB, Kanter SL, Sutkin G. Teaching techniques in the operating room: the importance of perceptual motor teaching. Acad Med. 2012 Mar;87(3):364-71. doi: 10.1097/ACM.0b013e31824484a0. PMID: 22373633.
  14. Nygaard I, Brubaker L, Chai TC, Markland AD, Menefee SA, Sirls L, Sutkin G, Zimmern P, Arisco A, Huang L, Tennstedt S, Stoddard A. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011 Oct;22(10):1255-65. doi: 10.1007/s00192-011-1429-9. Epub 2011 May 11.  PMID: 21560012.
  15. Martirosian Smith TE, Trowbridge ER, Pastore LM, Smith SC, Brennan MC, Dooley Y, Matthews CK, Ozel B, Sutkin G, Hullfish KL. Multicenter Urogynecology Study on Education: Medical Student Educational Experiences and Knowledge Outcomes During the OBGYN Clerkship. Female Pelvic Med Reconstr Surg. 2011 Mar;17(2):100-104. PMID: 22453697.
  16. Sutkin G, Daucher J, Zyczynski H. Prolapse in the Older Woman. European Urologic Review. 2010;5:64-8.
  17. Park AJ, Barber MD, Bent AE, Dooley YT, Dancz C, Sutkin G, Jelovsek JE. Assessment of intraoperative judgment during gynecologic surgery using the Script Concordance Test. Am J Obstet Gynecol. 2010 Sep;203(3):240.e1-6. doi: 10.1016/j.ajog.2010.04.010. Epub 2010 May 21. PMID: 20494330.
  18. Nager CW, Kraus SR, Kenton K, Sirls L, Chai TC, Wai C, Sutkin G, Leng W, Litman H, Huang L, Tennstedt S, Richter HE; Urinary Incontinence Treatment Network. Urodynamics, the supine empty bladder stress test, and incontinence severity. Neurourol Urodyn. 2010 Sep;29(7):1306-11. doi: 10.1002/nau.20836. PMID: 20127832.
  19. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug;21(8):955-61. doi: 10.1007/s00192-010-1137-x. Epub 2010 Mar 31. PMID: 20354678.
  20. Sutkin G, Littlefield JH, Laube DW. Nursing staff assessment of residents’ professionalism and communication skills. Med Educ. 2009 Nov;43(11):1104. doi: 10.1111/j.1365-2923.2009.03461.x. Epub 2009 Oct 2. PMID: 19799729.
  21. Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CISC) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Aug;20(8):933-8. doi: 10.1007/s00192-009-0885-y. Epub 2009 Apr 10. PMID: 19582384.
  22. Sutkin G, Aronoff CK. Resident front office experience: a systems-based practice activity. Med Educ Online. 2008 May 28;13:6. doi: 10.3885/meo.2008.T0000120. PMID: 20165536; PMCID: PMC2779599.
  23. Sutkin G, Wagner E, Harris I, Schiffer R. What makes a good clinical teacher in medicine? A review of the literature. Acad Med. 2008 May;83(5):452-66. doi: 10.1097/ACM.0b013e31816bee61. Review. PMID: 18448899.
  24. Sutkin G, Burley H, Zhang K, Arora N. Characteristics of good clinical educators from medical students perspectives: A Qualitative inquiry using a web-based survey system. International Journal of Healthcare Information Systems and Informatics. 2008;3(2):69-86.
  25. Sutkin G, Krohn MA, Heine RP, Sweet RL. Antibiotic prophylaxis and non-group B streptococcal neonatal sepsis. Obstet Gynecol. 2005 Mar;105(3):581-6. PMID: 15738028.
  26. Sutkin G, Mamlok V. Images in clinical medicine. Fetus papyraceus. N Engl J Med. 2004 Apr 15;350(16):1665. PMID: 15084699.

Complete list of publications


Photo of Jonathan Dubin M.D.
Jonathan Dubin M.D.
Assistant Professor – UMKC Truman Medical Center Hospital HillDepartment of Orthopaedic Surgery

A native of Kansas City, Dr. Jonathan Dubin joined the faculty in September 2013. He completed his undergraduate studies with a BS in Neuroscience at Tulane University in 2003 and his MD degree at the University of Kansas in 2007. He spent two years in the University of Illinois-Chicago Orthopaedic Surgery residency before transferring to the San Francisco Orthopaedic Surgery Residency Program, graduating in 2012. Dr. Dubin completed an Orthopaedic Trauma Fellowship at the University of Minnesota-Regions Hospital in 2013. He is board certified by the American Board of Orthopaedic Surgery


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Erin M. Guest, M.D.
Erin M. Guest, M.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Neurology/Neuroscience, Psychiatry

Neurology

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Affiliated Faculty

Photo of Nash N. Boutros, MBBCH
Nash N. Boutros, MBBCH
Department Chair and Professor Center for Behavioral MedicinePsychiatry

Prakash Chandra, M.D.
Assistant Professor Truman Medical Centers Behavioral HealthPsychiatry
  • Specialty: Child & Adolescent Psychiatry

Photo of Fu-Sheng Chou, M.D., Ph.D.
Fu-Sheng Chou, M.D., Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Xiang-Ping Chu, M.D., Ph.D.
Xiang-Ping Chu, M.D., Ph.D.
Associate Professor with Tenure Biomedical Sciences, Neuroscience Work M3-417 Work Phone: (816) 235-2248
  • Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Postdoctoral Fellowship (Neurobiology, 2004)
  • Fudan University Shanghai Medical College, Ph.D. (Physiology, 1999)
  • Fudan University Shanghai Medical College, MS (Physiology 1996)
  • Jiangsu University School of Medicine, MD (Clinical Medicine, 1989)
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Biography

Dr. Chu earned his medical degree from Jiangsu University School of Medicine in 1989, and his PhD degree from Fudan University Shanghai Medical College in 1999, both in the People’s Republic of China. He then came to America for postdoctoral training at the Legacy Research Institute in Portland, Oregon in 2000. He received a postdoctoral fellowship from the American Heart Association (AHA) in 2002 and subsequently received a beginning grant-in-aid in 2004 and scientist development grant in 2007, both from the AHA. While at the Legacy Research Institute, Dr. Chu was promoted from research associate to senior research associate, to assistant scientist. In 2008, he was recruited to the UMKC School of Medicine as a tenure-track Assistant Professor to establish an advanced, independent electrophysiology laboratory in a strategic expansion of neuroscience research program. In 2014, Dr. Chu was promoted to Associate Professor with tenure. His research focuses on the role of ion channels and membrane receptors in the pathogenesis of neurological disorders such as stroke and drug addiction. While at UMKC, his research has been supported by the National Institute of Health (NIH) and the AHA. Dr. Chu teaches medical neuroscience and physiology courses and is a member of UMKC’s doctoral faculty. He has published 3 book chapters and more than 50 peer-reviewed articles with an H-index of 18, and has served as a peer-reviewer for over 30 scientific journals. Dr. Chu currently serves on Editorial Boards for Advances in Neuroscience, International Journal of Physiology, Pathophysiology & Pharmacology (IJPPP), ISRN Physiology, and Scientific Reports. Dr. Chu also serves on grant study sections for the AHA, Medical Research Council of UK, Ataxia Foundation of UK, and the University of Missouri Research Board (UMRB).

Research Interest

One of my research interests is to understand the functional role of ion channels in ischemic brain injury. Brain ischemia induces various biochemical changes, which can activate various ion channels, including Acid-Sensing Ion Channels (ASICs). During hypoxia/ischemia, increased anerobic glycolysis due to the lack of blood and oxygen supply leads to lactic acid accumulation, causing a reduction in pH, and acidosis. For many years, acidosis has been known to play an important role in the pathology of neuronal injury. However, the cellular and molecular mechanisms underlying acidosis-induced injury remain elusive. Recently we have demonstrated that activation of newly described

ASICs contribute to neuronal injury, particularly those containing the ASIC1a subunit. My aim is to explore the potential mechanisms by which ASIC’s are involved in the pathogenesis of ischemic brain injury, particularly the extent to which they might be modulated/regulated by endogenous molecules (e.g. glucose and zinc). ASICs localize to synapses and proton as a neurotransmitter released from synaptic vesicles activates ASICs during neurotransmission. I am also interested in studying the functional role of ASICs in the brain and the interaction between ASICs and other ion channels/receptors (for example, glutamate receptors, dopamine receptors et al.,) during physiological or pathological conditions such as drug abuse. We want to determine whether ASICs play any roles in the pathogenesis of drug abuse or interact with other receptors in the brain in response to psychostimulants.

Mentoring Area

I am interested in mentoring students who have interests in neurological diseases such as drug abuse and ischemic brain injury using a combination of patch-clamp recording, fluorescence-imaging, gene transfection and knockdown, cell injury assay and behavior measurement techniques.

Recent Publications

*Chu XP, Grasing KA, Wang JQ. Acid-sensing ion channels contribute to neurotoxicity. Transl Stroke Res. 5(1):69-78, 2014. *Corresponding author.

Jing L, *Chu XP, *Zha XM. Three distinct motifs within the C-terminus of ASIC1a regulate its surface trafficking. Neuroscience. 247: 321-327, 2013. *Corresponding author.

Jiang Q, Wang CM, Fibuch EE, Wang JQ, *Chu XP. Differential regulation of locomotor activity to acute and chronic cocaine administration in acid-sensing ion channels 1a and 2 in adult mice. Neuroscience. 246C:170-178, 2013. *Corresponding author.

*Chu XP, Xiong ZG. Acid-sensing ion channels in pathological conditions. Adv Exp Med Biol. 961:419-31, 2013. *Corresponding author.

Jiang Q, Zha XM, *Chu XP. Inhibition of human acid-sensing ion channel 1b by zinc. Int J Physiol Pathophysiol Pharmacol4(2):84-93, 2012. *Corresponding author.

Wang JQ, Chu XP, Guo ML, Jin DZ, Xue B, Berry TJ, Fibuch EE, Mao LM. Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide. Front Physiol. 3:164, 2012.

*Chu XP, *Jing L,*Jiang YQ, Collier DM, Wang B, Jiang Q, Snyder PM and Zha XM. N-Glycosylation of ASIC1a regulates its trafficking and acidosis-induced spine remodeling. J Neurosci.  32(12):4080-4091, 2012. *These authors contributed equally.

*Chu XP, Xiong ZG. Physiological and pathological functions of acid-sensing ion channels in central nervous system. Curr Drug Targets. 13(2):263-271, 2012. *Corresponding author.

*Chu XP, Papasian CJ, Wang JQ and Xiong ZG. Modulation of Acid-Sensing Ion Channels: Molecular Mechanisms and Therapeutic Potential. Int J Physiol Pharmacol. 3(4):288-308, 2011. *Corresponding author.

Jing L, Jiang Q, Jiang YQ, Chu XP, and Zha XM. Interaction between the first transmembrane domain and the wrist of acid-sensing ion channel 1a is critical for its maturation and trafficking.  PLoS One, 6(10):e26909, 2011.

Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG, *Chu XP. Cysteine 149 in the extracellular finger domain of ASIC1b subunit is critical for zinc-mediated inhibition. Neuroscience, 193: 89-99, 2011. *Corresponding author.

Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 31: 2101-2112, 2011.

Van Dolah DK, Mao LM, Shaffer C, Guo ML, Fibuch EE, Chu XP, Buch S, Wang JQ. Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Bio Psychiatry. 69: 1035-1042, 2011.

Lin J, Chu XP, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong ZG. Inhibition of acid-sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 112:977-981, 2011.

*Chu XP, *Coombes E, *Jiang J, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiological relevant levels of hydrogen peroxide induces glutamate-independent neurodegeneration that involves activation of TRPM7 channels. Antioxid Redox Signal. 14: 1815-1827, 2011. *These authors contributed equally.

Suman A, Mehta B, Guo ML, Chu XP, Fibuch EE, Mao LM and Wang JQ. Alterations in acid-sensing ion channel expression in the rat forebrain following chronic amphetamine administration. Neurosci Res. 68: 1-8, 2010.

Jiang Q, Papasian CJ, Wang JQ, Xiong ZG and *Chu XP. Inhibitory regulation of acid-sensing ion channel 3 by zinc. Neuroscience. 169: 574-583, 2010. *Corresponding author.

*Chu XP, *Mao LM, *Wang W, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ, Fibuch EE, Buch S, Chen JG, Wang JQ. Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12: 602-10, 2009. *These authors contributed equally.

Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, *Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 162: 55-66, 2009. *Corresponding author.

Zhang GC, Mao LM, Wang JQ, *Chu XP. Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo. Neurosci Lett. 459:119-22, 2009. *Corresponding author.

Jiang J, Li MH, Inoue K, Chu XP, Seeds J, and Xiong ZG. TRPM7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res.,67:10929-38, 2007.

Liu X, Chu XP, Mao L, Wang M, Lan H, Li MH, Zhang G, Parelkar NK, Haines M, Neve KA, Liu F, Xiong ZG, and Wang JQ. Modulation of D2R/NR2B interactions in response to cocaine. Neuron, 52, 897-909, 2006.

Chu XP, Close N, Saugstad JA, and Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J. Neurosci., 26:5329-5339, 2006.

Xiong ZG, *Chu XP, *Zhu XM, Minami M, Hey J, Wemmie JA, Price M, Welsh MJ, and Simon RP.  Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118(6): 687-698, 2004. *These authors contributed equally.

Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG.   Subunit-dependent High-Affinity Zinc Inhibition of Acid-Sensing Ion Channels. J. Neurosci., 24 (40): 8678-8689, 2004.


Photo of Keith Coffman, M.D.
Keith Coffman, M.D.
Associate Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology
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Education

  • Medical School: Pennsylvania State University College of Medicine
  • Residency: Children’s Hospital of Pittsburgh – Neurodevelopmental Disabilities
  • Fellowship: University of Pittsburgh School of Medicine – Pediatric Scientist Development Program

For additional information, please click here.

 



Jessica A. Hellings, M.B.B.Ch.
Professor, University of Missouri-Kansas City Center for Behavioral MedicinePsychiatry


Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

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Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

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Matthew McLaughlin, M.D.
Assistant Professor Children’s Mercy Hospital

Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Paula Monaghan-Nichols, Ph.D.
Paula Monaghan-Nichols, Ph.D.
Associate Dean for Research, Chair and Professor Biomedical Sciences Biomedical Sciences Home M3-C02 Work Phone: (816) 235-6663
  • Trinity College, Dublin, Ireland, BA (Genetics)
  • Medical Research Council, Edinburgh, Scotland, Ph.D. (Genetic Engineering and Molecular Biology)
  • Medical Research Council, Human Genetics Unit, Edinburgh, Scotland, Post-Graduate (Molecular Genetics and Development)
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Research and Professional Experience

Postdoctoral Fellow/Research Associate, Molecular Biology of the Cell 1, German Cancer Research Centre, Heidelberg, Germany.

Assistant Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

 Associate Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Research Interest

Molecular Genetic Analysis of the Developmental Basis of Neuropsychiatric Disorders

Research Summary

My laboratory focuses on understanding the molecular and developmental basis of emotional and cognitive behavior and psychiatric illness. The long-term goal of my research is to identify both intrinsic and environmental factors that specifically alter the development of areas in the brain that are essential for emotion and cognition.  My laboratory has identified a number of transcriptional repressors (Tlx, Sall1, Sall2, Sall3 and Sall4) that are expressed in the developing forebrain. This research has shown that these genes are express in stem and progenitor cells in the cerebral cortex, and are required to regulate the rate of stem/progenitor cell proliferation and neuronal differentiation.  Using both conditional and classical knockout experiments and in-utero electroporation studies in mice, my laboratory has shown that altering the levels of these proteins during development leads to emotional, behavioral and cognitive abnormalities in adult animals.  Our most recent studies focus on identifying the cellular and biochemical targets of glucocorticoid action on the developing brain in-utero. Synthetic glucocorticoids are administered to mothers at risk for pre-term labor, to stimulate lung maturation and to reduce the risk of intraventricular hemorrhage and necrotizing enterocolitis. Clinical follow up studies indicate that children exposed to steroid in-utero have cognitive abnormalities and an altered stress response. My laboratory is using a combination of molecular, cellular, proteomic, RNA-Seq. and genome wide DNase hypersensitive site mapping to identify the cellular targets of steroid action. These studies have shown that prenatal exposure to glucocorticoids leads to changes in neuronal number and density in the cerebral cortex at birth coupled to long-term alterations in neurite complexity in the prefrontal cortex and hippocampus in adolescents. These anatomical abnormalities are associated with changes in anxiety and depressive like behaviors in adults. Follow up studies include validating our identified targets in human brain and in umbilical cord blood cells.  These findings will for a framework for modifying current clinical dosing regiments in preterm labor to reduce the adverse consequences of premature exposure to corticosteroids in-utero.

Selected Publications

Research Resource: The Dexamethasone Transcriptome in Hypothalamic Embryonic Neural Stem Cells.Frahm KA, Peffer ME, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan AP, DeFranco DB. Mol Endocrinol. 2016 Jan;30(1):144-54.

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.Kim SW, Fishilevich E, Arango-Argoty G, Lin Y, Liu G, Li Z, Monaghan AP, Nichols M, John B. PLoS One. 2015 Mar 23;10(3):e0120296..

Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells.Peffer ME, Chandran UR, Luthra S, Volonte D, Galbiati F, Garabedian MJ, Monaghan AP, DeFranco DB. Mol Cell Biol. 2014 Jul;34(14):2611-23.

Wu P1, Teot L, Murdoch GH, Monaghan-Nichols P, McFadden K.  Neuropathology of 22q11 Deletion Syndrome in an Infant. Pediatr Dev Pathol. 2014 17(5):386-92.

An in-depth map of polyadenylation sites in cancer. Lin Y, Li Z, Ozsolak F, Kim SW, Arango-Argoty G, Liu TT, Tenenbaum SA, Bailey T, Monaghan AP, Milos PM, John B. Nucleic Acids Res. 2012 Sep 1;40(17):8460-71.

Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Harrison SJ, Nishinakamura R, Jones KR, Monaghan AP. Dis Model Mech. 2012 May;5(3):351-65.

 Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Ozsolak F, Kapranov P, Foissac S, Kim SW, Fishilevich E, Monaghan AP, John B, Milos PM. Cell. 2010 Dec 10;143(6):1018-29. doi: 10.1016/j.cell.

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism.Kapranov P, Ozsolak F, Kim SW, Foissac S, Lipson D, Hart C, Roels S, Borel C, Antonarakis SE, Monaghan AP, John B, Milos PM. Nature. 2010 Jul 29;466(7306):642-6. doi: 10.1038/nature09190.

Sall3 is required for the terminal maturation of olfactory glomerular interneurons.Harrison SJ, Parrish M, Monaghan AP. J Comp Neurol. 2008 Apr 10;507(5):1780-94.

Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb. Harrison SJ, Nishinakamura R, Monaghan AP. Cereb Cortex. 2008 Jul;18(7):1604-17.

Abnormal development of zinc-containing cortical circuits in the absence of the transcription factor Tailless. Land PW, Monaghan AP. Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):97-101.

The Tlx gene regulates the timing of neurogenesis in the cortex. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP. J Neurosci. 2004 Sep 22;24(38):8333-45.

Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP. Mol Cell Biol. 2004 Aug;24(16):7102-12.

Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Land PW, Monaghan AP. Cereb Cortex. 2003 Sep;13(9):921-31.

Loss of the tailless gene affects forebrain development and emotional behavior. Roy K, Thiels E, Monaghan AP. Physiol Behav. 2002 Dec;77(4-5):595-600.

A new member of the spalt like zinc finger protein family, Msal-3, is expressed in the CNS and sites of epithelial/mesenchymal interaction. Ott T, Parrish M, Bond K, Schwaeger-Nickolenko A, Monaghan AP.= Mech Dev. 2001 Mar;101(1-2):203-7.

Defective limbic system in mice lacking the tailless gene. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. Nature. 1997 Dec 4;390(6659):515-7.


Mark Patterson, Ph.D., M.P.H.
Associate Professor UMKC School of Pharmacy

Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education

  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials

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Photo of Kim Smolderen, Ph.D.
Kim Smolderen, Ph.D.
Assistant Professor — Implementation Science Department of Biomedical & Health Informatics
  • 2012, Post-Doctoral Fellowship in Outcomes Research PRT: American Heart Association, St. Luke’s Mid-America Heart Institute
  • 2009, PhD in Medical Psychology, Tilburg University, Tilburg Netherlands
  • Research Interests: Identification of subpopulations at-risk of suboptimal health status and clinical outcomes in cardiac populations, with focus on patients with peripheral arterial disease (PAD).

Photo of Shayla A. Sullivant, M.D.
Shayla A. Sullivant, M.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of John Qiang Wang, M.D., Ph.D.
John Qiang Wang, M.D., Ph.D.
Acting Associate Dean for Research and Professor Departments of Anesthesiology & Biomedical Sciences Work M3-225 Work Phone: (816) 235-1907
  • Westport Anesthesia / Missouri Endowed Chair for Research
  • M.D. Degree: Tongji Medical University, Wuhan, China
  • MS Degree: Tongi Medical University, Wuhan, China
  • Ph.D, Degree: Shanghai Medical University, Shanghai China
  • Fellowship: Beijing Medical University, Beijing China
  • Fellowship: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
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Biography

John Q. Wang is a Westport Anesthesia/Missouri Endowed Chair in the Department of Anesthesiology and a Professor in the Departments of Anesthesiology and Basic Medical Science at UMKC School of Medicine since 2004. He earned his medical degree in Tongji Medical University in 1982 and his Ph.D. in Shanghai Medical University in 1988. Dr. Wang’s research primarily focuses on drug abuse and addiction. He currently leads a research team supported by NIH grants to conduct animal experiments from molecule to behavior and from in vitro to in vivo. In addition, Dr. Wang is interested in elucidating molecular mechanisms for anesthesia induction.

 

Selected Publications

Mao LM, Fibuch EE and Wang JQ. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron. 67: 679-681.

Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM and Wang JQ. (2010). CaMKIIα interacts with M4 muscarinic receptors to control receptor and psychomotor function. EMBO J. 29: 2070-2081.

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ and Buch S. (2010). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115: 4951-4962.

Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ. Fibuch EE, Buch S, Chen JG, Wang JQ. (2009). Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12:602-610. PMC2749993.

Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M and Wang JQ. (2009). Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 61:425-438. PMC2650276.

Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG and Wang JQ. (2006). Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 52:897-909.

Yang L, Mao L, Chen H, Catavsan M, Kozinn J, Arora A, Liu X and Wang JQ. (2006). A signaling mechanism from Gαq-protein-coupled glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J Neurosci. 26: 971-980.

Mao L, Yang L, Tang Q, Samdani S, Zhang G and Wang JQ. (2005). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 25: 2741-2752.

Yang L, Mao L, Tang Q, Samdani S, Liu Z and Wang JQ. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 24: 10846-10857.

Obstetrics & Gynecology

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Obstetrics and Gynecology

Affiliated Faculty

Jenifer Allsworth, Ph.D.
Research Associate Professor Department of Biomedical & Health Informatics
  • Ph.D. — Epidemiology, Brown University
  • Research Interests: Impact of social factors, including race, violence, and poverty, on obstetric and gynecologic outcomes; the use of social media for delivery of weight gain interventions among disadvantaged reproductive-aged women at risk for obesity; and the impact of alterations of the vaginal microbiome on health outcomes.

Photo of Peter Koulen, Ph.D.
Peter Koulen, Ph.D.
Departments of Ophthalmology & Biomedical Sciences Work Phone: (816) 404-1824

Professor and Felix and Carmen Sabates Missouri Endowed Chair in Vision Research
Director of Basic Research, Vision Research Center
Department of Ophthalmology

Professor
Department of Biomedical Sciences

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Research Interest

Dr. Koulen is a Professor of Ophthalmology and Biomedical Sciences and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research at the UMKC School of Medicine. He trained at the Max-Planck-Institute for Brain Research, Yale University and the Marine Biological Laboratory. His research focuses on basic research on and therapy development for chronic diseases of the eye and brain. He is an internationally recognized expert in biophysics, biochemistry and physiology of nerve cells and his research has been funded continually since 2002 by national and international foundations and agencies including the NIH’s National Eye Institute, National Institute on Aging, National Cancer Institute, National Center for Research Resources, National Institute of Diabetes and Digestive and Kidney Diseases, and the U.S. DOD among others. As principal or co-investigator for over $20 million in extramural grant funding for research studies, Dr. Koulen’s research program has fundamental relevance to basic science, translational research and therapy development as evidenced by over 120 peer-reviewed publications in scientific journals, and 10 book chapters. Dr. Koulen has over 25 years of experience in the fields of neuroscience and eye research, drug development, translational research, biological sciences, biostatistics, and routinely interprets complex data sets with distinct public health significance. Dr. Koulen serves as reviewer for more than 50 professional scientific journals, serves on over 15 editorial boards and is editor in chief of two scientific journals. He is a review panel member for several national and international funding agencies including the National Science Foundation, the National Institutes of Health, the U.S. Department of Defense and other national and international government agencies and research foundations. The University of Missouri – Kansas City Board of Trustees recognized Dr. Koulen with the N.T. Veatch Award for Distinguished Research and Creativity. Through this Faculty Award, UMKC and the UMKC Trustees are recognizing the very best faculties, who have distinguished themselves through scholarship and creativity.

Vision research

Degeneration or acute damage of nerve cells in the retina is a major cause of visual loss and blindness in the United States and worldwide. As diseases such as glaucoma, macular degeneration and diabetic retinopathy affect significant and increasing portions of the U.S. population, including minorities affected by disparities in health care delivery, determining causes, mechanisms of action and subsequently potential treatment strategies will contribute to improving health care, health and performance requiring visual tasks.

The Vision Research Center was founded as and is a well-established collaboration of several UMKC schools and Kansas City Medical Centers and thus offers an unprecedented interdisciplinary synergy with a unified goal: to better diagnose, prevent, and treat eye disease and vision disorders through translational research in order to make a difference in the lives of tens of millions of people worldwide. To this end, the center conducts federally and industry funded basic, translational and clinical research to develop new medical therapies and offers patient care in all subspecialties of ophthalmology. The center’s nationally recognized excellence in research, patient care and medical education contribute to UMKC’s strengths in the life sciences. Objectives of the Vision Research Center are to:

  • Provide a direct avenue for basic and translational research in eye and related diseases,
  • Transfer basic science findings seamlessly into practical use with patients through translational research,
  • Develop new therapy approaches urgently needed by physicians in the US and worldwide,
  • Provide educational excellence,
  • Ensure patients receive the most advanced medical treatments available,
  • Become a national center of excellence for eye research.
Publications:

My NCBI Collections


Photo of Timothy G. Myrick, M.D.
Timothy G. Myrick, M.D.
Assistant Professor, University of Missouri-Kansas City Truman Medical CenterCommunity & Family Medicine

Patient Quality of Life

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Patient Quality of Life

Affiliated Faculty


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Kim Smolderen, Ph.D.
Kim Smolderen, Ph.D.
Assistant Professor — Implementation Science Department of Biomedical & Health Informatics
  • 2012, Post-Doctoral Fellowship in Outcomes Research PRT: American Heart Association, St. Luke’s Mid-America Heart Institute
  • 2009, PhD in Medical Psychology, Tilburg University, Tilburg Netherlands
  • Research Interests: Identification of subpopulations at-risk of suboptimal health status and clinical outcomes in cardiac populations, with focus on patients with peripheral arterial disease (PAD).

Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City

Pediatrics

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Pediatrics

Affiliated Faculty

Photo of Susana Chavez-Bueno, M.D.
Susana Chavez-Bueno, M.D.
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Fu-Sheng Chou, M.D., Ph.D.
Fu-Sheng Chou, M.D., Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Xiang-Ping Chu, M.D., Ph.D.
Xiang-Ping Chu, M.D., Ph.D.
Associate Professor with Tenure Biomedical Sciences, Neuroscience Work M3-417 Work Phone: (816) 235-2248
  • Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Postdoctoral Fellowship (Neurobiology, 2004)
  • Fudan University Shanghai Medical College, Ph.D. (Physiology, 1999)
  • Fudan University Shanghai Medical College, MS (Physiology 1996)
  • Jiangsu University School of Medicine, MD (Clinical Medicine, 1989)
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Biography

Dr. Chu earned his medical degree from Jiangsu University School of Medicine in 1989, and his PhD degree from Fudan University Shanghai Medical College in 1999, both in the People’s Republic of China. He then came to America for postdoctoral training at the Legacy Research Institute in Portland, Oregon in 2000. He received a postdoctoral fellowship from the American Heart Association (AHA) in 2002 and subsequently received a beginning grant-in-aid in 2004 and scientist development grant in 2007, both from the AHA. While at the Legacy Research Institute, Dr. Chu was promoted from research associate to senior research associate, to assistant scientist. In 2008, he was recruited to the UMKC School of Medicine as a tenure-track Assistant Professor to establish an advanced, independent electrophysiology laboratory in a strategic expansion of neuroscience research program. In 2014, Dr. Chu was promoted to Associate Professor with tenure. His research focuses on the role of ion channels and membrane receptors in the pathogenesis of neurological disorders such as stroke and drug addiction. While at UMKC, his research has been supported by the National Institute of Health (NIH) and the AHA. Dr. Chu teaches medical neuroscience and physiology courses and is a member of UMKC’s doctoral faculty. He has published 3 book chapters and more than 50 peer-reviewed articles with an H-index of 18, and has served as a peer-reviewer for over 30 scientific journals. Dr. Chu currently serves on Editorial Boards for Advances in Neuroscience, International Journal of Physiology, Pathophysiology & Pharmacology (IJPPP), ISRN Physiology, and Scientific Reports. Dr. Chu also serves on grant study sections for the AHA, Medical Research Council of UK, Ataxia Foundation of UK, and the University of Missouri Research Board (UMRB).

Research Interest

One of my research interests is to understand the functional role of ion channels in ischemic brain injury. Brain ischemia induces various biochemical changes, which can activate various ion channels, including Acid-Sensing Ion Channels (ASICs). During hypoxia/ischemia, increased anerobic glycolysis due to the lack of blood and oxygen supply leads to lactic acid accumulation, causing a reduction in pH, and acidosis. For many years, acidosis has been known to play an important role in the pathology of neuronal injury. However, the cellular and molecular mechanisms underlying acidosis-induced injury remain elusive. Recently we have demonstrated that activation of newly described

ASICs contribute to neuronal injury, particularly those containing the ASIC1a subunit. My aim is to explore the potential mechanisms by which ASIC’s are involved in the pathogenesis of ischemic brain injury, particularly the extent to which they might be modulated/regulated by endogenous molecules (e.g. glucose and zinc). ASICs localize to synapses and proton as a neurotransmitter released from synaptic vesicles activates ASICs during neurotransmission. I am also interested in studying the functional role of ASICs in the brain and the interaction between ASICs and other ion channels/receptors (for example, glutamate receptors, dopamine receptors et al.,) during physiological or pathological conditions such as drug abuse. We want to determine whether ASICs play any roles in the pathogenesis of drug abuse or interact with other receptors in the brain in response to psychostimulants.

Mentoring Area

I am interested in mentoring students who have interests in neurological diseases such as drug abuse and ischemic brain injury using a combination of patch-clamp recording, fluorescence-imaging, gene transfection and knockdown, cell injury assay and behavior measurement techniques.

Recent Publications

*Chu XP, Grasing KA, Wang JQ. Acid-sensing ion channels contribute to neurotoxicity. Transl Stroke Res. 5(1):69-78, 2014. *Corresponding author.

Jing L, *Chu XP, *Zha XM. Three distinct motifs within the C-terminus of ASIC1a regulate its surface trafficking. Neuroscience. 247: 321-327, 2013. *Corresponding author.

Jiang Q, Wang CM, Fibuch EE, Wang JQ, *Chu XP. Differential regulation of locomotor activity to acute and chronic cocaine administration in acid-sensing ion channels 1a and 2 in adult mice. Neuroscience. 246C:170-178, 2013. *Corresponding author.

*Chu XP, Xiong ZG. Acid-sensing ion channels in pathological conditions. Adv Exp Med Biol. 961:419-31, 2013. *Corresponding author.

Jiang Q, Zha XM, *Chu XP. Inhibition of human acid-sensing ion channel 1b by zinc. Int J Physiol Pathophysiol Pharmacol4(2):84-93, 2012. *Corresponding author.

Wang JQ, Chu XP, Guo ML, Jin DZ, Xue B, Berry TJ, Fibuch EE, Mao LM. Modulation of ionotropic glutamate receptors and acid-sensing ion channels by nitric oxide. Front Physiol. 3:164, 2012.

*Chu XP, *Jing L,*Jiang YQ, Collier DM, Wang B, Jiang Q, Snyder PM and Zha XM. N-Glycosylation of ASIC1a regulates its trafficking and acidosis-induced spine remodeling. J Neurosci.  32(12):4080-4091, 2012. *These authors contributed equally.

*Chu XP, Xiong ZG. Physiological and pathological functions of acid-sensing ion channels in central nervous system. Curr Drug Targets. 13(2):263-271, 2012. *Corresponding author.

*Chu XP, Papasian CJ, Wang JQ and Xiong ZG. Modulation of Acid-Sensing Ion Channels: Molecular Mechanisms and Therapeutic Potential. Int J Physiol Pharmacol. 3(4):288-308, 2011. *Corresponding author.

Jing L, Jiang Q, Jiang YQ, Chu XP, and Zha XM. Interaction between the first transmembrane domain and the wrist of acid-sensing ion channel 1a is critical for its maturation and trafficking.  PLoS One, 6(10):e26909, 2011.

Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG, *Chu XP. Cysteine 149 in the extracellular finger domain of ASIC1b subunit is critical for zinc-mediated inhibition. Neuroscience, 193: 89-99, 2011. *Corresponding author.

Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 31: 2101-2112, 2011.

Van Dolah DK, Mao LM, Shaffer C, Guo ML, Fibuch EE, Chu XP, Buch S, Wang JQ. Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo. Bio Psychiatry. 69: 1035-1042, 2011.

Lin J, Chu XP, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong ZG. Inhibition of acid-sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 112:977-981, 2011.

*Chu XP, *Coombes E, *Jiang J, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiological relevant levels of hydrogen peroxide induces glutamate-independent neurodegeneration that involves activation of TRPM7 channels. Antioxid Redox Signal. 14: 1815-1827, 2011. *These authors contributed equally.

Suman A, Mehta B, Guo ML, Chu XP, Fibuch EE, Mao LM and Wang JQ. Alterations in acid-sensing ion channel expression in the rat forebrain following chronic amphetamine administration. Neurosci Res. 68: 1-8, 2010.

Jiang Q, Papasian CJ, Wang JQ, Xiong ZG and *Chu XP. Inhibitory regulation of acid-sensing ion channel 3 by zinc. Neuroscience. 169: 574-583, 2010. *Corresponding author.

*Chu XP, *Mao LM, *Wang W, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ, Fibuch EE, Buch S, Chen JG, Wang JQ. Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12: 602-10, 2009. *These authors contributed equally.

Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, *Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 162: 55-66, 2009. *Corresponding author.

Zhang GC, Mao LM, Wang JQ, *Chu XP. Upregulation of acid-sensing ion channel 1 protein expression by chronic administration of cocaine in the mouse striatum in vivo. Neurosci Lett. 459:119-22, 2009. *Corresponding author.

Jiang J, Li MH, Inoue K, Chu XP, Seeds J, and Xiong ZG. TRPM7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res.,67:10929-38, 2007.

Liu X, Chu XP, Mao L, Wang M, Lan H, Li MH, Zhang G, Parelkar NK, Haines M, Neve KA, Liu F, Xiong ZG, and Wang JQ. Modulation of D2R/NR2B interactions in response to cocaine. Neuron, 52, 897-909, 2006.

Chu XP, Close N, Saugstad JA, and Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J. Neurosci., 26:5329-5339, 2006.

Xiong ZG, *Chu XP, *Zhu XM, Minami M, Hey J, Wemmie JA, Price M, Welsh MJ, and Simon RP.  Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 118(6): 687-698, 2004. *These authors contributed equally.

Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG.   Subunit-dependent High-Affinity Zinc Inhibition of Acid-Sensing Ion Channels. J. Neurosci., 24 (40): 8678-8689, 2004.


Photo of Erin M. Guest, M.D.
Erin M. Guest, M.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Mark Hoffman, Ph.D.
Mark Hoffman, Ph.D.
Department of Biomedical & Health Informatics

 

  • Research Associate Professor – Biomedical & Health Informatics
  • ResearchAssociate Professor – Pediatrics
  • Children’s Mercy Hospital – Director Translational Bioinformatics
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Biography

Dr. Mark Hoffman received his Ph.D. from the University of Wisconsin – Madison and performed post-doctoral research at the National Animal Disease Center in Ames, Iowa. Before joining UMKC, he spent 16 years leading genomics, public health and research initiatives at Cerner Corporation, where he was a Vice President. In addition to his peer-reviewed publications, Mark is an inventor on 16 issued patents.

Research Interests

The integration of genomic information with electronic health records, genomic clinical decision support, the use of informatics to accelerate research and the analysis of large de-identified clinical data sets to reach new insights.

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Photo of Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Agostino Molteni, M.D., Ph.D., F.A.C.C.B.
Director of Student Research UMKC School of Medicine
  • Professor of Pathology & Pharmacology – UMKC School of Medicine
  • Professor Emeritus of Pathology – Northwestern University
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Research Interests

Dr. Molteni’s main research interest is the study of development of interstitial pulmonary fibrosis (IPF) in several models of experimental lung injury: exposure to radiation and hypoxia, administration of bleomycin and fat embolism syndrome. Also studied is the role played by the renin angiotensin system in the development of fibrosis and the antifibrotic protection of angiotensin converting inhibitors or angiotensin II receptor blockers.

His projects are conducted in cooperation with Dr. Betty Herndon (UMKC SOM); Dr. T. McIff, Dept. of Orthopedic Surgery and Dr. A. Poisner, Dept. of Pharmacology, University of Kansas Medical Center, Dr. B. Uhal, Dept. of Physiology, Michigan State University, Dr. R. Baybutt, Dept. of Health Sciences, Wheaton College, Wheaton, IL., Dr. G Van Den Heuvel, Dept. of Physiology, Eastern Michigan University, Kalamazoo, MI.

Research Career Development Award, National Institutes of Health, 1972
Albert E. Lasker Award, 1980, to NHLBI sharing as principal investigator, Central Laboratory Hypertension Detection and Follow-up Program
Meritorious Service Award, Chicago Heart Association,1982
Clinical Chemists Recognition Award, 1983

Recent research includes the evaluation of exenatide in a rodent model of non-alcoholic liver steatosis, and in particular, the drug’s effect on the pancreas and the thyroid of these animals. This study was performed in cooperation with Dr. Herndon, Dr. Laura Alba, and others of the Dept. of Medicine, in the UMKC SOM. An additional study is the evaluation of pulmonary and cardiac damage in a model of Cux-1 mice expressing the cyclin kinase inhibitors P21 and P27 (Drs Baybutt and Van Den Heuvel).

Selected Publications

Has published more than 200 articles and book chapters and more than 370 presentations at national and international scientific meetings.

Curcumin Effects on Hepatic Steatosis and Histopathology in an Obese Mouse Model. British Journal of Medicine and Medical Research: 5(8): 1017-1023, 2015. Article no BJMMP.2015.112

Fat Embolism sensitizes rats to a “second hit” with LPS: an animal model of Pulmonary Fibrosis: Journal of Trauma and Acute Surgical Care; 783:552-557, 2015

Fat Embolism Syndrome following caesarean section in an obese patient and it’s similarity to an animal model of the same syndrome: a case report. Case reports in Clinical Pathology: Published online 3-3-2015, D01110.5430/crcp.vnp

NF-KB controls Resistance of Human Salivary Gland (HSG) Cells to apoptosis in an in vitro model of Sjögren syndrome. Open Journal of Rheumatology and Auto immune Diseases (OJRA): Vol 4 #3; ID: 2040 128, 2014

Mitigating effect of Captopril and Losartan on Lung Histopathology in a rat model of Fat Embolism. The Journal of Trauma 70 (5):1186-1191; 2011

Biochemical and Histological Effects of Exendin 4 (exenatide) in the rat pancreas. Diabetologia53(1):153-159; 2010

“Persistent and progressive fibrotic changes in a model of fat embolism.” Journal of Trauma 72 (h) 992-998, 2012

“Dietary flaxseed oil protects against bleomycin-induced pulmonary fibrosis in rats.” Pulmonary Medicine, published on line, June 2012 10457031 doi 0.1155/2012/457031

“Urease and Helicobacter spp. Antigens in Pulmonary Granuloma” Journal of Comparative Pathology(2012) http://dx.doi.org/10.1016/j.jcpa.2012.06.011

“Effect of exendin (exenatide) on the thyroid and parathyroid gland in a rat model.” Eur. J., of Pharmacology 2012 http://dx.doi.org/10.1016/j.ejphar.2012.07.024 


Photo of Paula Monaghan-Nichols, Ph.D.
Paula Monaghan-Nichols, Ph.D.
Associate Dean for Research, Chair and Professor Biomedical Sciences Biomedical Sciences Home M3-C02 Work Phone: (816) 235-6663
  • Trinity College, Dublin, Ireland, BA (Genetics)
  • Medical Research Council, Edinburgh, Scotland, Ph.D. (Genetic Engineering and Molecular Biology)
  • Medical Research Council, Human Genetics Unit, Edinburgh, Scotland, Post-Graduate (Molecular Genetics and Development)
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Research and Professional Experience

Postdoctoral Fellow/Research Associate, Molecular Biology of the Cell 1, German Cancer Research Centre, Heidelberg, Germany.

Assistant Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

 Associate Professor, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA

Research Interest

Molecular Genetic Analysis of the Developmental Basis of Neuropsychiatric Disorders

Research Summary

My laboratory focuses on understanding the molecular and developmental basis of emotional and cognitive behavior and psychiatric illness. The long-term goal of my research is to identify both intrinsic and environmental factors that specifically alter the development of areas in the brain that are essential for emotion and cognition.  My laboratory has identified a number of transcriptional repressors (Tlx, Sall1, Sall2, Sall3 and Sall4) that are expressed in the developing forebrain. This research has shown that these genes are express in stem and progenitor cells in the cerebral cortex, and are required to regulate the rate of stem/progenitor cell proliferation and neuronal differentiation.  Using both conditional and classical knockout experiments and in-utero electroporation studies in mice, my laboratory has shown that altering the levels of these proteins during development leads to emotional, behavioral and cognitive abnormalities in adult animals.  Our most recent studies focus on identifying the cellular and biochemical targets of glucocorticoid action on the developing brain in-utero. Synthetic glucocorticoids are administered to mothers at risk for pre-term labor, to stimulate lung maturation and to reduce the risk of intraventricular hemorrhage and necrotizing enterocolitis. Clinical follow up studies indicate that children exposed to steroid in-utero have cognitive abnormalities and an altered stress response. My laboratory is using a combination of molecular, cellular, proteomic, RNA-Seq. and genome wide DNase hypersensitive site mapping to identify the cellular targets of steroid action. These studies have shown that prenatal exposure to glucocorticoids leads to changes in neuronal number and density in the cerebral cortex at birth coupled to long-term alterations in neurite complexity in the prefrontal cortex and hippocampus in adolescents. These anatomical abnormalities are associated with changes in anxiety and depressive like behaviors in adults. Follow up studies include validating our identified targets in human brain and in umbilical cord blood cells.  These findings will for a framework for modifying current clinical dosing regiments in preterm labor to reduce the adverse consequences of premature exposure to corticosteroids in-utero.

Selected Publications

Research Resource: The Dexamethasone Transcriptome in Hypothalamic Embryonic Neural Stem Cells.Frahm KA, Peffer ME, Zhang JY, Luthra S, Chakka AB, Couger MB, Chandran UR, Monaghan AP, DeFranco DB. Mol Endocrinol. 2016 Jan;30(1):144-54.

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.Kim SW, Fishilevich E, Arango-Argoty G, Lin Y, Liu G, Li Z, Monaghan AP, Nichols M, John B. PLoS One. 2015 Mar 23;10(3):e0120296..

Caveolin-1 regulates genomic action of the glucocorticoid receptor in neural stem cells.Peffer ME, Chandran UR, Luthra S, Volonte D, Galbiati F, Garabedian MJ, Monaghan AP, DeFranco DB. Mol Cell Biol. 2014 Jul;34(14):2611-23.

Wu P1, Teot L, Murdoch GH, Monaghan-Nichols P, McFadden K.  Neuropathology of 22q11 Deletion Syndrome in an Infant. Pediatr Dev Pathol. 2014 17(5):386-92.

An in-depth map of polyadenylation sites in cancer. Lin Y, Li Z, Ozsolak F, Kim SW, Arango-Argoty G, Liu TT, Tenenbaum SA, Bailey T, Monaghan AP, Milos PM, John B. Nucleic Acids Res. 2012 Sep 1;40(17):8460-71.

Sall1 regulates cortical neurogenesis and laminar fate specification in mice: implications for neural abnormalities in Townes-Brocks syndrome. Harrison SJ, Nishinakamura R, Jones KR, Monaghan AP. Dis Model Mech. 2012 May;5(3):351-65.

 Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Ozsolak F, Kapranov P, Foissac S, Kim SW, Fishilevich E, Monaghan AP, John B, Milos PM. Cell. 2010 Dec 10;143(6):1018-29. doi: 10.1016/j.cell.

New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism.Kapranov P, Ozsolak F, Kim SW, Foissac S, Lipson D, Hart C, Roels S, Borel C, Antonarakis SE, Monaghan AP, John B, Milos PM. Nature. 2010 Jul 29;466(7306):642-6. doi: 10.1038/nature09190.

Sall3 is required for the terminal maturation of olfactory glomerular interneurons.Harrison SJ, Parrish M, Monaghan AP. J Comp Neurol. 2008 Apr 10;507(5):1780-94.

Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb. Harrison SJ, Nishinakamura R, Monaghan AP. Cereb Cortex. 2008 Jul;18(7):1604-17.

Abnormal development of zinc-containing cortical circuits in the absence of the transcription factor Tailless. Land PW, Monaghan AP. Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):97-101.

The Tlx gene regulates the timing of neurogenesis in the cortex. Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP. J Neurosci. 2004 Sep 22;24(38):8333-45.

Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality. Parrish M, Ott T, Lance-Jones C, Schuetz G, Schwaeger-Nickolenko A, Monaghan AP. Mol Cell Biol. 2004 Aug;24(16):7102-12.

Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Land PW, Monaghan AP. Cereb Cortex. 2003 Sep;13(9):921-31.

Loss of the tailless gene affects forebrain development and emotional behavior. Roy K, Thiels E, Monaghan AP. Physiol Behav. 2002 Dec;77(4-5):595-600.

A new member of the spalt like zinc finger protein family, Msal-3, is expressed in the CNS and sites of epithelial/mesenchymal interaction. Ott T, Parrish M, Bond K, Schwaeger-Nickolenko A, Monaghan AP.= Mech Dev. 2001 Mar;101(1-2):203-7.

Defective limbic system in mice lacking the tailless gene. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. Nature. 1997 Dec 4;390(6659):515-7.


Photo of Cy B. Nadler, Ph.D.
Cy B. Nadler, Ph.D.
Assistant Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Shui Qing Ye, M.D., Ph.D.
Shui Qing Ye, M.D., Ph.D.
Professor & the William R. Brown / Missouri Endowed Chair Medical Genetics & Molecular MedicineDepartment of Biomedical & Health Informatics
  • 1993, PhD, University of Chicago Pritzker School of Medicine, Chicago IL
  • 1982, Doctor of Medicine, Wuhan University School of Medicine, Wuhan China
  • Research Interests: Next generation DNA sequencing, Translational Bioinformatics and integrative strategy of animal model, biochemical, cellular, molecular and omic approaches to identify new diagnostic biomarkers and novel therapeutic targets to complex human diseases such as acute respiratory distress syndrome, coronary heart disease, chronic kidney disease and drug induced liver injury.

Photo of Venkatesh Sampath, M.B.B.S
Venkatesh Sampath, M.B.B.S
Associate Professor, University of Missouri-Kansas City Children’s Mercy HospitalPediatrics

Photo of Steven M. Shapiro, M.D., M.H.A.
Steven M. Shapiro, M.D., M.H.A.
Division Director of Child Neurology, CMH, Professor, UMKC School of Medicine Children’s Mercy HospitalDepartment of Neurology, Child Neurology, Clinical Neurophysiology
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Education

  • Medical School: University of Pittsburgh School of Medicine
  • Residency: Case Western Reserve University – Pediatrics
  • Fellowship: Children’s Hospital of Pittsburgh – Child Neurology
  • Fellowship: University of Pittsburgh – Auditory Neurophysiology
  • Fellowship: University of Wisconsin – Evoked Potentials

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Photo of John Qiang Wang, M.D., Ph.D.
John Qiang Wang, M.D., Ph.D.
Acting Associate Dean for Research and Professor Departments of Anesthesiology & Biomedical Sciences Work M3-225 Work Phone: (816) 235-1907
  • Westport Anesthesia / Missouri Endowed Chair for Research
  • M.D. Degree: Tongji Medical University, Wuhan, China
  • MS Degree: Tongi Medical University, Wuhan, China
  • Ph.D, Degree: Shanghai Medical University, Shanghai China
  • Fellowship: Beijing Medical University, Beijing China
  • Fellowship: Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee
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Biography

John Q. Wang is a Westport Anesthesia/Missouri Endowed Chair in the Department of Anesthesiology and a Professor in the Departments of Anesthesiology and Basic Medical Science at UMKC School of Medicine since 2004. He earned his medical degree in Tongji Medical University in 1982 and his Ph.D. in Shanghai Medical University in 1988. Dr. Wang’s research primarily focuses on drug abuse and addiction. He currently leads a research team supported by NIH grants to conduct animal experiments from molecule to behavior and from in vitro to in vivo. In addition, Dr. Wang is interested in elucidating molecular mechanisms for anesthesia induction.

 

Selected Publications

Mao LM, Fibuch EE and Wang JQ. (2010). Decoding BDNF-LTP coupling in cocaine addiction. Neuron. 67: 679-681.

Guo ML, Fibuch EE, Liu XY, Choe ES, Buch S, Mao LM and Wang JQ. (2010). CaMKIIα interacts with M4 muscarinic receptors to control receptor and psychomotor function. EMBO J. 29: 2070-2081.

Yao H, Yang Y, Kim KJ, Bethel-Brown C, Gong N, Funa K, Gendelman HE, Su TP, Wang JQ and Buch S. (2010). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115: 4951-4962.

Mao LM, Wang W, Chu XP, Zhang GC, Liu XY, Yang YJ, Haines M, Papasian CJ. Fibuch EE, Buch S, Chen JG, Wang JQ. (2009). Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine. Nat Neurosci. 12:602-610. PMC2749993.

Liu XY, Mao LM, Zhang GC, Papasian CJ, Fibuch EE, Lan HX, Zhou HF, Xu M and Wang JQ. (2009). Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron. 61:425-438. PMC2650276.

Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG and Wang JQ. (2006). Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 52:897-909.

Yang L, Mao L, Chen H, Catavsan M, Kozinn J, Arora A, Liu X and Wang JQ. (2006). A signaling mechanism from Gαq-protein-coupled glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway. J Neurosci. 26: 971-980.

Mao L, Yang L, Tang Q, Samdani S, Zhang G and Wang JQ. (2005). The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 25: 2741-2752.

Yang L, Mao L, Tang Q, Samdani S, Liu Z and Wang JQ. (2004). A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 24: 10846-10857.

Radiology

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Radiology

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