Tag Archives: Research

Research Summit posters, abstracts due March 17

Organizers of the annual UMKC Health Sciences Student Research Summit are encouraging students to submit their abstracts and posters to participate in this year’s event.

The 2019 summit will take place from 3-5 p.m. on April 17 at the UMKC Student Union, Room 401. Deadline for submissions is March 27.

The research summit fosters research collaborations across disciplines and school that will produce economic, health, education and quality-of-life benefits for the greater Kansas City community. It is an opportunity for students to present their research to School of Medicine faculty.

Students must submit  their abstracts through the REDCap Submission Portal at https://is.gd/2019HSSRS. Posters must be submitted by email to the School of Medicine’s Office of Research Administration at hsdresearch@umkc.edu.

A School of Medicine poster template and complete poster guidelines are available online through the Office of Research Administration. Students may have their poster layouts reviewed by John Foxworth, Pharm. D. prior to submitting their poster to the research office. He can be contacted at FoxworthJ@umkc.edu.

Students can also sign up for a time to practice their presentations by sending an email to the research office at hsdresearch@umkc.edu.

The School of Medicine sponsors individual awards for medical students and its graduate students.

This is the seventh year that the schools are participating in the program at one venue on the Volker Campus. Last year, 50 students from the School of Medicine’s M.D. and Allied Health programs presented 45 posters at the research summit.

Health Sciences
Student Research Summit
Important links

Submissions Due: March 27
REDCap Submission Portal: https://is.gd/2019HSSRS

Research Poster Template: http://med.umkc.edu/docs/research/HSSRS_2019_poster_template.pptx
SOM Office of Student Research: hsdresearch@umkc.edu
Poster review with Dr. Foxworth: FoxworthJ@umkc.edu
Additional information: Courtney Dixon / 816-235-5366 /hsdresearch@umkc.edu

 

Revered UMKC professor, clinician honored by family

A recent contribution to the UMKC Foundation from the family of former School of Medicine faculty member Larry Pibenga, M.D., will support a research study on corneal calcification, led by Peter Koulen, Ph.D., endowed chair and co-director of vision research.

Colleagues who knew Larry Piebenga, MD, speak of him with true regard as both a mentor and role model for medical research, education and patient care.  A legendary ophthalmologist and teacher at UMKC, Piebenga was a pioneer for developing cornea and cataract therapies.

“Many of the ophthalmology techniques used today were first developed and implemented in clinics by Dr. Piebenga,” says Peter Koulen, PhD, UMKC professor and the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research. “Our faculty members still try to emulate him.”

Dr. Pibenga

“Dr. Piebenga was my mentor during my residency at UMKC,” says Timothy Walline, MD, assistant professor in UMKC’s Department of Ophthalmology. “His calm, caring manner inspired me then, and not a week goes by that I don’t fondly recall something he taught me. His sincere approach to each and every patient has been my guidepost in 25 years of practice and academic endeavors.”

“He always did the right thing no matter what the work involved was and cared for every patient no matter who they were,” says Abraham Poulose MD, FACS, associate professor in UMKC’s Department of Ophthalmology. “I have aspired to live my life, both personally and professionally, to the example that he set.”

In memory of Piebenga, his family has made a contribution to the UMKC Foundation to support a research study on corneal calcification, led by Koulen. The basic science study hopes to find ways of more precisely assessing corneal calcification and determining how changes that occur from the condition affect the ability to accurately diagnose eye diseases.

“This is potentially a high-impact study that affects the outcome of many patients,” says Koulen. “By properly diagnosing their condition, we can work to develop new therapies for eye diseases that affect patients’ vision.”

Koulen said he is excited that Piebenga’s family is making this gift to honor his legacy and hopes it inspires others to honor their loved ones with similar tributes.

“Dr. Piebenga was a true advocate of research funding and he put that commitment into action,” says Koulen.  “As an avid philanthropist, he supported vision research at the UMKC Foundation, and the family’s gift showcases the mindset of Dr. Piebenga – that research is essential to our mission.”

He says their contribution also fills a critical gap for research funding as public funds are very competitive and are dwindling. “Donor gifts for small, initial studies such as this can lead to major funding for larger studies down the road,” he says.

“Research hinges on new discoveries, and philanthropy is a critical key in this process.”

Researcher Karl Kador receives Research to Prevent Blindness award

Karl Kador, Ph.D.

School of Medicine researcher Karl Kador, Ph.D.,  has received a $75,000 award from the Research to Prevent Blindness/Stavros Niarchos Foundation International Research Collaborators.

The grant is intended to support and promote international collaborations among researchers in the United States and abroad to gain new scientific knowledge and skills through activities within the department of ophthalmology. A researcher at the UMKC Vision Research Center, Kador has been working to develop a novel approach for treating patients suffering end-stage glaucoma.

Last year, Kador received a nearly $2-million National Institutes of Health grant to explore tissue engineering that could one day lead to a method of transplanting new retinal ganglion cells to replace old, dead cells.

The Research to Prevent Blindness award allows researchers to spend time working with one another to advance specific research goals. These international collaborations can have a positive impact on a world-wide population. They have the potential to speed the development of treatments for illnesses that lead to blindness.

School of Medicine researcher receives NIH award for study of sepsis

Fu, Mingui
Mingui Fu, Ph.D.

The National Institutes of Health recently awarded School of Medicine researcher Mingui Fu, Ph.D.,  associate professor of biomedical sciences, a $465,000 grant to conduct a study of sepsis-induced systemic inflammation.

Fu said that when completed, his research could significantly advance scientists’ understanding of the regulatory mechanisms surrounding septic pathogenesis and identify a new therapeutic target to treat the devastating condition.

A potentially life-threatening illness, sepsis is a major health concern. It strikes nearly 700,000 people in the United States each year with a 30 percent mortality rate. A major contributor to mortality is sepsis-induced systemic inflammation followed by multi-organ injury.

Sepsis appears when infectious bacteria or other organisms enter the blood stream and cause an inflammatory immune response. There is currently no specific treatment available for sepsis.

Fu’s study will look at the essential role of a particular protein known as myeloid MCPIP1 in sepsis-induced systemic inflammation and death. It will also explore whether MCPIP1 may be a target for pharmacological therapy to improve the outcome of sepsis.

Charlie Inboriboon, M.D., associate professor of emergency medicine, will serves as a co-investigator on the study, which will also include the research efforts of School of Medicine students.

American Heart Association honors Dr. John Spertus with Distinguished Scientist Award

John Spertus, M.D., M.P.H., professor of medicine and Daniel J. Lauer, M.D., Endowed Chair in Metabolism and Vascular Disease Research, was honored with the American Heart Association’s 2018 Distinguished Scientist Award.

John Spertus, M.D., M.P.H., professor of medicine and Daniel J. Lauer, M.D., Endowed Chair in Metabolism and Vascular Disease Research, received the American Heart Association’s 2018 Distinguished Scientist Award on Nov. 11 at the AHA Scientific Sessions in Chicago.

The award recognizes prominent scientists and clinicians who have made significant and sustained contributions to advancing the understanding, management and treatment of cardiovascular disease and stroke.

As clinical director of outcomes research at Saint Luke’s Mid America Heart Institute, Spertus developed technology that guides physicians and patients in medical-decision making by using models to measure and predict the risk factors of various procedures. Many experts cite two tools he created — the Seattle Angina Questionnaire and the Kansas City Cardiomyopathy Questionnaire — as the gold standards for measuring symptoms, function and quality of life in treating coronary artery disease and heart failure. Both have been translated into more than 95 languages.

“I am humbled by the honor to be recognized by the AHA for our work to improve the patient-centeredness of care,” Spertus said. “While traditionally the basic sciences are prioritized, to see the work of our community to improve care and outcomes is a terrific validation of the collective efforts of my entire team and colleagues.”

Spertus is the founder of two outcomes research organizations. The Cardiovascular Outcomes Research Consortium and CV Outcomes is a non-profit corporation dedicated to advancing health care quality and outcomes research in cardiovascular disease. The Health Outcomes Sciences is an information technology company that implements precision medicine in clinical care.

He is currently leading a regional effort with BioNexus KC and the Frontiers CTSA to bring local hospitals together in collaboration to improve the value of health care in Kansas City.

This is Spertus’ third major award from the AHA. He previously received the organization’s Lifetime Achievement Award in 2015 and the Council on Quality of Care and Outcomes Research Distinguished Achievement Award in 2013.

Student research office announces 12 Sarah Morrison awards

Top row: Yicheng Bao, Shannon Demehri, Abygail Dulle, Ankit Kadakia. Middle row: Cynthia Liu, Andrew Peterson, Amber (Lelia) Sarvestani, Som Singh. Bottom row: Kevin Varghese, Firas Al-Badarin, Kathryn Kyler, Ali O. Malik

The School of Medicine Student Research Program has awarded 12 Sarah Morrison Student Research Awards for the Fall 2018 cycle. Recipients included nine medical students and three graduate students.

Sarah Morrison awards of up to $2,500 are presented to School of Medicine students each year in April and October. The awards help students become involved in and learn about a wide variety of research activities based on their interests. The research may be in the basic sciences or in clinical medicine.

Students may develop their own hypothesis and work plan or work on an established research project with their mentor. Winners of the awards are expected to present the results of the research at a School of Medicine student research event such as the UMKC Health Sciences Student Research Summit) or a similar venue as recommended by Research Administration.

More than 100 students have received Sarah Morrison awards since 2013 with an estimated $155,000 of financial support provided from the program to conduct research projects at the School of Medicine.

The next application deadline for students interested in receiving a Sarah Morrison research award is March 1 for the April award. Applicants are reviewed by a committee of faculty judges and processed through the Office of Research Administration.

For complete application information, visit the student research website.

Fall 2018 Sarah Morrison Research Awards
(Recipient / Faculty Mentor / Project title)
  • Yicheng Bao, MS 4 / Betty Drees, M.D., Professor, Dean Emerita / Prevalence and Risk Factors of Depression Among Patients with Diabetic Retinopathy
  • Shannon Demehri, MS 6 / John Wang, M.D., Ph.D., Professor, Westport Anesthesia/Missouri Endowed Chair for Research / Regulation of Src Family Kinases in the Rat Brain by Adenosine
  • Abygail Dulle, MS 5/ Paula Monaghan-Nichols, Ph.D., Professor, Associate Dean for Research Administration / Prenatal Glucocorticoid Exposure for Preterm Birth: Investigating The Role Of Glucocorticoid Receptor Phosphorylation In The Development Of Neuropathology
  • Ankit Kadakia, MS 4 / Paula Monaghan-Nichols, Ph.D., Professor, Associate Dean for Research Administration / Role of Synthetic Glucocorticoid Exposure in Ocular Development and Pathology
  • Cynthia Liu, MS 4/ Gary Sutkin, M.D., Professor and Associate Dean of Women’s Health, Victor and Caroline Schutte Chair in Women’s Health / The Prevalence and Effects of Ambiguous Language on Communication Errors in the Operating Room
  • Andrew Peterson, MS 5 / Xiangping Chu, M.D., Ph.D., Associate Professor of Biomedical Sciences / Modulation of Heteromeric Acid-Sensing Ion 1 a/3 Channels by Zinc
  • Amber (Lelia) Sarvestani, MS 6 / Geetha Raghuveer, M.D., M.P.H., Professor of Pediatrics / Long Term Outcomes and Survival Following Repair of Truncus Arteriosus With and Without Interrupted Aortic Arch Utilizing Linkage of the Pediatric Cardiac Care Consortium with the National Death Index and Organ Procurement Transplantation Network Datasets
  • Som Singh, MS 2 / Li Zhang, M.D., Professor of Biomedical and Health Informatics / The Effect of GM26870 Gene Expression on Acetaminophen Hepatotoxicity
  • Kevin Varghese, MS 2 / Alain Cuna, M.D., Assistant Professor of Pediatrics / Effectiveness and safety of repeat use of postnatal steroids for bronchopulmonary dysplasia
  • Firas Al-Badarin, grad student / Tim Bateman, M.D., Professor of Internal Medicine and Radiology / Cardiovascular Outcomes of Patients with Normal Positron Emission Tomography and Single Photon Computed Tomography Myocardial Perfusion Imaging
  • Kathryn Kyler, grad student / Kim Smolderen, Ph.D., Assistant Professor of Biomedical and Health Informatics / Variation in medication dosing and guideline adherence by weight status for commonly prescribed medications during pediatric asthma hospitalizations
  • Ali O. Malik, grad student / Paul Chan, M.D., Professor of Internal Medicine / Association between hospital reimbursement models and rates of normal elective coronary angiograms

Sutkin receives NIH grant to develop technology for safer surgeries

Gary Sutkin, M.D., has received a $600,000 research grant from the National Institutes of Health to develop technology that will make surgeries safer.

Gary Sutkin, M.D., director of the UMKC School of Medicine’s Surgical Innovations Laboratory, has received a three-year, $600,000 grant from the National Institutes of Health to develop simulation technology that can be used to prevent surgical errors.

With magnetic resonance imaging (MRI) and a 3-D printer, Sutkin plans to create a high-fidelity pelvic simulator and use motion analysis to identify surgical errors involved in Midurethral Sling surgery.

Sutkin, professor of surgery, serves as associate dean for women’s health and is Victor and Caroline Shutte Endowed Chair in Women’s Health at the School of Medicine. He chose this particular surgery for his research because it is common in older women and includes a high-risk step. During the procedure, the surgeon must blindly guide a sharp, pointed steel trocar past vital structures, including the bladder, bowel, and major blood vessels.

Performed to improve quality of life, the procedure also has the potential for catastrophic outcomes.

The project will use MRI to create a virtual model of a human pelvis of a patient with reproducible stress urinary incontinence. From that, a 3-D model will be printed, assembled and tested for fidelity to human tissue.

A group of five seasoned surgeon who are experts in Midurethral Surgery and five surgeons who are novices in the procedure will perform the surgery on the model. Motion analysis will collect kinematic data of shoulder, elbow, and wrist motions. The information will be combined into a 3-D model to analyze movements that lead to the most common errors: perforation of the bladder or bowel, and injury to the external iliac veins.

Sutkin’s groundbreaking research has the potential to have a major impact on the prevention of surgical errors by minimizing patient distress and health care costs. Once successful, Sutkin said he plans to incorporate the technology into the School of Medicine’s surgical residency program and apply the approach to reducing errors in other surgeries.

Two students selected for Children’s Mercy neurology research award

Shrushti Mehta, Andrew Williams

Shrushti Mehta and Andrew Williams, fourth-year students at the School of Medicine, have been selected to receive an award from the Children’s Mercy Hospital Philanthropy Fund to support research interests in neurology.

Recipients of the Neurology Research and Scholar Award work on research projects with Jennifer Bickel, M.D., and her research team in the Headache Research Group in the Division of Neurology at Children’s Mercy Kansas City. An associate professor of pediatrics, Bickel serves as director of the Comprehensive Headache Clinic at Children’s Mercy.

Students work closely with the research group to design, implement and present research findings in the area of pediatric headache assessment and management. They also attend the American Academy of Neurology annual conference where they can network with other professionals in the field, attend presentations and poster displays and other pertinent educational opportunities.

Research projects focus on headache treatment but also vary based on current studies being conducted at any given time within the group.

The research fellowship award is available to qualified fourth, fifth or sixth-year B.A./M.D. students or second, third or fourth-year M.D. students at the School of Medicine. Students must commit to at least 80 total research hours throughout a 12-month period. A medical school research elective with the Children’s Mercy Hospital Department of Neurology is highly encouraged.

Bao contributes to published articles relating Type 1 diabetes to autoimmune disease

Third-year medical student Yicheng Bao has co-authored two recent journal articles related to research on a link between Type 1 diabetes and autoimmune disease.

He was the first author of an article published in the September issue of Wiley Journal of Diabetes, “High prevalence of comorbid autoimmune diseases in adults with type 1 diabetes from the HealthFacts database.” He also is a co-author of an article published in October on the American Diabetes Association web site, “Diabetes Care, titled, Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease.”

Bao began his research during a summer medical student research program at Washington University in St. Louis. The program was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Bao continued working on the study when he returned to school at UMKC for the fall semester.

The study showing that adults diagnosed with type 1 diabetes are at greater risk of developing additional autoimmune conditions has been reported in a number of health care and diabetes-related media outlets.

Pediatrics researcher receives humanitarian award

Richard Schwend, M.D., professor of orthopaedics and pediatrics, received the Walter P. Blount Humanitarian Award from the Scoliosis Research Society.

Richard Schwend, M.D., professor of orthopaedics and pediatrics, was recently honored with the Walter P. Blount Humanitarian Award by the Scoliosis Research Society.

The award recognizes outstanding service to patients with spinal deformities and generosity to the profession of scoliosis research. It was presented during the 53rd annual Scoliosis Research Society Annual Meeting in Bologna, Italy, in October.

Schwend serves as chief of orthopaedic research at Children’s Mercy Hospital, one of the UMKC School of Medicine’s partner teaching hospitals. He recently completed the Global Clinical Research Training Research Program at Harvard University.

For the past 18 years, Schwend has been active in a humanitarian effort in Ecuador for children with spinal deformities. He also serves as the medical director for Project Perfect World, Ecuador, a program that sponsors the Ecuador Spine Project.

The immediate past president of the Pediatric Orthopaedic Society of North America, Schwend received the organization’s Humanitarian Award in 2014 and its Special Effort award in 2013. He also served as chair of the Orthopaedic Section of the American Academy of Pediatrics from 2010-2014 and created a scholarship program to provide residents with international global experiences.