Musculoskeletal Biology

UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT).

This enterprise, under the leadership of Dr. Lynda Bonewald, represents a multidisciplinary and interdisciplinary center that includes investigators from the Schools of Dentistry, Medicine, Nursing, and Computing and Engineering to focus on dental and musculoskeletal health. This UMKC Center of Excellence integrates all investigators, whether basic or clinical, into a powerful translational team to prevent and treat diseases of teeth, cartilage, bone, and muscle.

The major objective of the Center is to expand the ability to make new discoveries in the basic sciences, and to translate these findings into diagnostic tests, prognostic indicators, and therapeutic interventions for diseases of muscle and mineralized tissues. There are four major objectives for this center;

  • Develop a world-class basic science research program in mineralized tissues.
  • Create an outcomes science platform and clinical trial networks.
  • Provide education from graduate students and clinicians.
  • Establish an infrastructure to develop biotechnology and technology transfer.

Drs. Jon Andresen, Ming Zhao and Michael Wacker are BMS faculty members who contribute to the research mission of CEMT.

Vision Research Center (VRC)

UMKC’s nationally recognized Vision Research Center (VRC) is dedicated to advancing and promoting optimal vision health in the community and worldwide.  The VRC is an innovative research organization that integrates interdisciplinary collaborative research teams from the Departments of Ophthalmology and Biomedical Sciences at the School of Medicine, as well as faculty from the School of Pharmacy. The teams ­through strong interaction between basic, translational and clinical researchers ­bring discoveries in vision research to patients and their communities.

Dr. Peter Koulen is the Felix and Carmen Sabates Missouri Endowed Chair in Vision Research and serves as co-director of the VRC.  Dr. Koulen’s research is focused on developing new treatment strategies for diseases that damage nerve cells in the central nervous system and the eye.

Dr. Scott Duncan is interested in the immune system’s effect on the visual system and its role in the development of chronic diseases of the retina.

Dr. Karl Kador’s research focuses on injuries and diseases of the optic nerve, such as glaucoma, that lead to the death of the retinal ganglion cells, which connect the retina to the brain.  Dr. Kador employs methods for transplanting new cells to replace the cells that have died and uses tissue engineering to direct these cells through the retina and to the optic nerve to develop a treatment that will restore vision to patients suffering end stage diseases affecting the retina and optic nerve.

Neuroscience Research

wang_BMSCare of the neurologically impaired patient is a growing and important aspect of healthcare today. Neurological impairments requiring specialized knowledge and care span a wide spectrum from chronic pain, epilepsy, drug addiction, and paralysis due to spinal injury or stroke, to neurodegenerative disorders such as Parkinson’s Disease and Multiple Sclerosis. Recent advances in the broad discipline of Neuroscience has enhanced our fundamental knowledge of neural function and contributed to the development of novel therapeutic interventions such as the pharmacologic or mechanical removal of intravascular brain thrombi, and the implantation of brain electrodes to control muscular function. Despite these advancements in knowledge and treatment modalities, we are just scratching the surface, and there will continue to be an increasing demand for neuroscience research to meet the expanding needs for new drugs and technology to diagnose and treat neurological disorders. The ability to translate basic scientific research into clinical settings is vital to the advancement of neurological care, and the School of Medicine is active in both clinical and basic neuroscience research.

An advanced basic neuroscience research laboratory, under the direction of Dr. John Wang, has been established at the SOM. The research focuses on molecular signaling mechanisms triggered by drugs of abuse, as well as those used in clinical anesthesiology. Dr. Xiangping Chu is another important member of the neursoscience research group. His research focuses on the functional role of ion channels in ischemic brain injury.

Shock / Trauma Research

The Shock/Trauma Research Center at the UMKC School of Medicine brings clinicians and scientists together to bridge the gap between basic science and clinical care. Investigators conduct basic and applied research on the mechanisms involved in tissue injury and organ failure in shock and on the development of new therapeutic intervention strategies to effectively treat the injured and diseased patients.

Nilofer Qureshi, Ph.D., professor of biomedical sciences and internationally renowned for her research on septic shock, is director of the Center. One of the few such centers in the Midwest, it is adjacent to Truman Medical Center, the largest Level I trauma center in Western Missouri. Nearly 1,000 patients per year are admitted to the TMC trauma center, approximately 40% with gunshot or knife wounds, and 20% with hemorrhagic shock and sepsis/shock. The Center is ideally suited to develop innovative techniques to treat shock based on proteasome modulators, which can be readily transferred to improve the care of septic civilians in the community, or septic wounded soldiers on the battlefield.

Several research investigators with diverse areas of expertise related to shock, including molecular biology, chemistry, biochemistry, surgery and models of septic shock conduct research at the Center. Clinical research activities involve investigators from the UMKC School of Medicine’s Departments of Biomedical Science and Emergency Medicine, and the Level 1 trauma center of TMC Hospital Hill. The Shock/Trauma Research Center will also create a sepsis and infectious disease focus group involving Children’s Mercy Hospital and Saint Luke’s Hospital of Kansas City.

Dr. David C. Morrison and Dr. Charles Van Way III pioneered the Shock/Trauma Research Center and are presently appointed as Emeritus Professors.

MOLECULAR & CELLULAR IMMUNOLOGY (Sepsis/shock/inflammation)
Director:  Nilofer Qureshi, Ph.D. Professor (tenured), BMS
Neerupma Silswal, Ph. D   Assistant Research Professor, BMS
Monica Gaddis, Ph.D. Assist Research Professor, Bioinformatics
Gary Gaddis, M.D. Professor, St. Louis. (Clinical)
Charlie Inboriboon, M.D. Associate Professor (Clinical) TMC
COLLABORATORS
Peter Koulen, Ph.D. Professor BMS
Mike Wacker, Ph.D. Associate. Professor BMS
Mark Hoffman, Ph.D. (Children’s Mercy Hospital)
Emeritus Professors working on the Sepsis project:
David Morrison, Ph.D.
Van Way, M.D (Clinical)
Asaf A. Qureshi, Ph.D.
INFLAMMATION & SEPSIS
Director: Mingui Fu, Ph.D. Associate Professor. BMS

Contact Us

Department of Basic Medical Science
M3-C03 (Third floor)
UMKC School of Medicine
2411 Holmes Street
Kansas City, MO 64108
Phone: 816-235-5172
Fax: 816-235-6517
Paula Monaghan-Nichols, Ph.D.
Chair
816-235-6663
nicholsap@umkc.edu
Michael Wacker, Ph.D.
Vice-chair
816-235-6069
wackerm@umkc.edu
Cheryl Jones
Administrative Assistant
816-235-5172
joneschery@umkc.edu

 

Chemical Management at SOM

Hazardous chemicals are managed by the UMKC Environmental Health and Safety Office (EHS). EHS maintains the University bar-coding system to inventory and track hazardous materials at UMKC. EHS works with every lab and conducts audits of each lab. In addition, EHS provides emergency response efforts for chemical spills.
Dr. Xiangping Chu is the School of Medicine representative for UMKC Chemical Safety Committee.

SOM researchers should contact the Office of Research Administration at somresearch@umkc.edu or (816)235-6247 when new chemicals are received, hazardous chemicals need to be removed, or assistance with the new inventory system and management of chemical inventories in labs. Research Administration will contact Suban Burale in the SOM Biomedical Sciences Dept. as Suban is the point of contact as of Sept. 1, 2017, for all chemical management in the SOM.

Faculty

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Xiang-Ping Chu, M.D., Ph.D.

Associate Professor, Tenured
Department(s) of Biomedical Sciences
Section: Neurosciences
UMKC School of Medicine Chu, Xiang-Ping

Specialties and Research/Medical Interests

Anesthesiology, Neurology, Pediatric Prenatal

Chu, Xiang-Ping
235-2248
M4-108
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Maria Cole, Ph.D., M.Ed.L.

Associate Teaching Professor
Department(s) of Biomedical Sciences
Section: Anatomy
UMKC School of Medicine
Cole, Maria
235-1904
M3-423
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Theodore Cole, III, Ph.D.

Teaching Professor
Department(s) of Biomedical Sciences
Section: Anatomy
UMKC School of Medicine
Cole, Theodore
235-1829
M3-413
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Wail M. Hassan, Ph.D, M(ASCP)CM

Associate Teaching Professor
Department(s) of Biomedical Sciences
Section: Microbiology
UMKC School of Medicine

Specialties and Research/Medical Interests

Autism spectrum disorder, multivariate immune profiling

Hassan, Wail M.
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Rosa H. Huang, Ph.D.

Professor, UMKC Grievance Hearing Panel
Department(s) of Biomedical Sciences
Section: Biochemistry
UMKC School of Medicine
Huang, Rosa H.
235-2589
M3-425
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Seung Suk Kang, Ph.D., M.A.

Assistant Professor
Department(s) of Biomedical Sciences
UMKC School of Medicine
Kang, Seung Suk
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Karl Kador, Ph.D.

Assistant Professor
Department(s) of Biomedical Sciences, Ophthalmology
UMKC School of Medicine Kador, Karl
Kador, Karl
235-6766
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Peter Koulen, Ph.D., FARVO

Professor, Felix and Carmen Sabates / Missouri Endowed Chair in Vision Research, Director of Basic Research, Vision Research Center
Department(s) of Biomedical Sciences, Ophthalmology
Section: Neurosciences
Vision Research Center Koulen, Peter
Koulen, Peter
235-6773
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Limin Mao, M.D., Ph.D.

Research Professor
Department(s) of Biomedical Sciences
Section: Pharmacology
UMKC School of Medicine
Mao, Limin
235-1719
M5-207
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Darla McCarthy, Ph.D.

Associate Teaching Professor, Assistant Dean - Curriculum
Department(s) of Biomedical Sciences
Section: Biochemistry
UMKC School of Medicine
McCarthy, Darla
235-1736
M3-419
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Paula Monaghan-Nichols, Ph.D.

Professor, Associate Dean - Research Administration, Chair - Biomedical Sciences
Department(s) of Biomedical Sciences
UMKC School of Medicine Monaghan-Nichols, Paula

Specialties and Research/Medical Interests

Community and Family Medicine, Neurology, Pediatric Oncology

Monaghan-Nichols, Paula
235-6663
M3-403
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Willard Morrow, V.M.D., Ph.D.

Associate Teaching Professor
Department(s) of Biomedical Sciences
Section: Physiology, Histology, Pathology
UMKC School of Medicine
Morrow, Willard
235-5717
M3-125
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Mark Nichols, Ph.D.

Chair, Associate Professor - Department of Biomedical and Health Informatics, Director of Research Development, School of Medicine,
Department(s) of Biomedical Sciences, Biomedical and Health Informatics
UMKC School of Medicine
Nichols, Mark
235-1855
M5-101
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Christopher Papasian, Ph.D., D(ABMM)

Professor Emeritus
Department(s) of Biomedical Sciences
Section: Microbiology/Immunology
UMKC School of Medicine
Papasian, Christopher
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Bart Patenaude, M.D.

Assistant Teaching Professor, Interim Medical Director - Physician Assistant Program
Department(s) of Biomedical Sciences
UMKC School of Medicine
Patenaude, Bart
235-1984
M3-415
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Nilofer Qureshi, Ph.D.

Professor, Director – Shock/Trauma Research Center, Director, Molecular & Cellular Immunology
Department(s) of Biomedical Sciences
Section: Microbiology
UMKC School of Medicine Qureshi, Nilofer
Qureshi, Nilofer
235-1056
MG-CO5E
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Chad D. Touchberry, Ph.D., M.S.

Assistant Teaching Professor
Department(s) of Biomedical Sciences
UMKC School of Medicine
Touchberry, Chad D.
235-1983
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Michael Wacker, Ph.D.

Associate Professor, Associate Dean - Academic Affairs, Vice-chair - Biomedical Science
Department(s) of Biomedical Sciences
Section: Physiology
UMKC School of Medicine Wacker, Michael

Specialties and Research/Medical Interests

Cardiology, Cell Biology

Wacker, Michael
235-6069
HSB 2232
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John Q. Wang, M.D., Ph.D.

Professor, Westport Anesthesia / Missouri Endowed Chair for Research
Department(s) of Anesthesiology, Biomedical Sciences
UMKC School of Medicine Wang, John

Specialties and Research/Medical Interests

Biochemistry, Cardiology, Anesthesiology, Pediatric Prenatal, Neurology

Wang, John Q.
235-1907
M3-225
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Kristin Wright, Ph.D.

Associate Teaching Professor
Department(s) of Biomedical Sciences
UMKC School of Medicine
Wright, Kristin
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Department of Biomedical Sciences

Basic-Medical-Science_Heart-Lab
The Department of Biomedical Sciences (formerly Basic Medical Science) was established in 1998 in response to recommendations by the American Association of Medical College’s Liaison Committee on Medical Education following an accreditation inspection. The newly established department was initially charged with the responsibility of improving the quality and relevance of basic science education for medical students. As the department has matured, we have also focused on developing research programs in specific biomedically related disciplines.

Departmental Teaching Responsibilities

Medical Students

Biochemistry
Gross Anatomy
Histology
Physiology
Medical Microbiology
Immunology
Medical Neuroscience

Dental Students

Gross Anatomy
Histology

Dental Hygiene Students

Anatomy

Anesthesiology Assistant Students

Anatomy
Physiology

Physician Assistant Students

Anatomy
Biochemistry
Immunology
Microbiology
Physiology

Departmental Research Initiatives

Shock/Trauma Research
Neuroscience Research
Vision Research
Musculoskeletal Biology

Central Lab (room # M3-C04F)

(816) 235-5172
joneschery@umkc.edu

Equipment and supplies
  • Large-volume autoclave
  • Deionized water station
  • Air dryers
  • Flask scrubber
  • BIOHAZ (red bins) medical waste container pick up/drop off area
  • Freezers -80 C
  • Dry Ice available for lab specimen shipments – contact at least 3 business days prior to shipment. Larger amounts more than #10 lbs. (4 blocks) require at least 7 business days advance notice to schedule preparation.
    • Please email your cancellation by noon the day before, if dry ice is not needed
  • Distilled water available. Contact at least 48 hours in advance. 5 gallons of distilled water containers are available, limited to one request per business day.
  • Light and fluorescence microscopes equipped with PAXcam microscope camera, and PAX-it imaging software.
  • Laboratory Equipment Available
    • Mulit-image Light Cabinet
    • Plate Reader
    • Centrifuge
    • Affymetrix Microarray Analysis
Sharps Policy and Disposal:
Training:

All new-hire researchers are required to attend an orientation training prior to utilizing the Central Lab.

Central Lab Orientation Video (requires WMV player and UMKC SSO)

Per School of Medicine (SOM) policy – research investigators, staff, students, and volunteers that work in SOM laboratories including the Central Lab, must complete biohazard training from CITI.

For more info see – https://med.umkc.edu/ora/human_subjects

Hazardous Chemical Management:
  • Hazardous chemicals are managed by the UMKC Environmental Health and Safety Office (EHS).  EHS maintains the University bar-coding system to inventory and track hazardous materials at UMKC. EHS works with every lab and conducts audits of each lab. In addition, EHS provides emergency response efforts for chemical spills.
  • Dr. Xiangping Chu is the School of Medicine representative for UMKC Chemical Safety Committee.
  • SOM researchers should contact joneschery@umkc.edu or (816)235-5172 when new chemicals are received, hazardous chemicals need to be removed, or assistance with the new inventory system and management of chemical inventories in labs. Cheryl will contact Suban Burale, as Suban is the point of contact as of Sept. 1, 2017, for all chemical management in the SOM.
Compressed Gas Cylinders

Safety Compressed Gas Cylinders – Handling and Use, Transportation and Storage

Equipment and Supply Request

The Department of Biomedical Sciences has equipment and supplies available for request for research purposes only. A list of equipment and supplies can be found below.