J. Steven Leeder, Ph.D., Pharm.D.

Department(s) of Pediatrics
Section: Pharmacology/Toxicology
Children's Mercy Hospital
Meet J. Leeder
Research Summary

My research focuses on the application of pharmacogenetic and pharmacogenomic strategies to characterize the relative contributions of ontogeny, genetic variation, and disease to observed variability in drug disposition and response in children. Almost all of our current projects are components of the GOLDILOKs initiative – Genomic- and Ontogeny-Linked Dose Individualization and cLinical Optimization for Kids, and generally involve individualization of dose to achieve a standardized systemic drug exposure to better investigate variability in response.