Tag Archives: Alzheimer’s Disease

SOM researcher develops technology for early detection of Alzheimer’s

Patients can be tested for early-stage Alzheimer’s disease with a microperimeter, a machine already used regularly in eye exams.
Koulen, Peter
Peter Koulen, Ph.D.

According to the Alzheimer’s Association, more than 5-million Americans live with Alzheimer’s disease, which is the sixth leading cause of death in the United States. At UMKC School of Medicine, researcher Peter Koulen, Ph.D., has found an innovative way to diagnose the early stages of the disease – with an eye exam.

The test was developed at the School of Medicine’s Vision Research Center, where Koulen serves as director of basic research. It provides a non-invasive, fast-screening tool for early detection of Alzheimer’s and mild cognitive impairment, a precursor to Alzheimer’s.

Koulen’s work received a patent in January and has been attracting attention since. With support from the university’s Office of Technology Commercialization, it is now drawing interest from local manufacturers and diagnostic companies.

Koulen said the technology has received overtures from local investors interested in forming a startup company to license and further develop it, as well.

“There are business people now on our doorstep,” he said.

The test uses a microperimeter, a machine routinely used in eye exams to evaluate retina function, and typically takes less than half an hour.

And it is a relatively simple test for patients. One looks into the machine and presses a button when they see a flash of light. A computer program progresses through a series of flashing lights in various locations and intensities to measure the person’s retinal function.

“This is a technology that is already widely used by ophthalmologists,” Koulen said. “Over the years, we’ve found some different uses for it, and the Alzheimer’s diagnostics is one example of that. It’s basically a boring video game that you play for a few minutes.”

Because it was developed through clinical studies with patients and subjects, the transition from discovery to use in clinics could be relatively short. Compare that to other research, like creating a cancer drug, which could take decades of development.

“We’ve worked about half a decade on this,” Koulen said.

The technology evolved through researching therapies for glaucoma, macular degeneration and diabetic retinopathy, major eye diseases affecting the retina. These have been the focus of much of Koulen’s work at UMKC since joining the Vision Research Center in 2009.

The retina, a light-sensitive tissue, is part of the body’s central nervous system and is connected to the brain. Koulen and his team spent about seven years developing a still-growing database to define a baseline for healthy retina function. Using microperimetry, they were able to recognize subtle deviations from those baseline figures beyond normal aging. They linked those deviations to what they realized could be indicators of early-stage Alzheimer’s and mild cognitive impairment.

“We were able to pick up that these patients very likely had the neurological disorder before the neurologist was able to diagnose the very earliest forms of the disease,” Koulen said.

There is no single exam for diagnosing Alzheimer’s. The current method is an often cumbersome, time-consuming process of eliminating other potential causes of a neurological disorder. Results can be inconclusive until the disease has progressed to a more-advanced stage. By that point, treatment and patient care has become a primary concern.

A more rapid and conclusive diagnosis is possible with the test Koulen has developed. It can easily be given in a clinic or other settings. That could make the technology enticing for investors.

“The nice thing about conducting the diagnostics in the clinic is that they’re non-invasive,” Koulen said. “You don’t have to draw blood. You don’t need anesthesia. It’s basically a very complicated eye exam, but it’s still an eye exam.”