Department of Internal Medicine

Department Faculty


A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | Y

 

Photo of Laura Alba, M.D.
Laura Alba, M.D.
Associate Professor of Medicine Saint Luke’s Campus
  • Specialty: Gastroenterology & Hepatology
  • Medical School: University of San Luis Potosi, Mexico
  • Internal Medicine Residency: University of Missouri-Kansas City
  • Gastroenterology Fellowship: University of Missouri-Kansas City
  • Hepatology Fellowship: Mayo Clinic
Rana Al-Zoubi, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Jordan, Amman, JordanResidency: Internal Medicine, University of Missouri – Kansas City
Photo of Javed Ashraf, M.D., M.R.C.P., M.P.H., F.A.C.C, F.S.C.A.I
Javed Ashraf, M.D., M.R.C.P., M.P.H., F.A.C.C, F.S.C.A.I

Assistant Professor of Medicine – UMKC School of Medicine
Interventional Cardiologist – Truman Medical Center

  • Specialty: Cardiovascular Disease
  • Medical School: Punjab Medical College/Punjab University, Pakistan
  • Residency: Internal Medicine, Baystate Medical Centre/Tufts University, Springfield, MA
  • Fellowship: Geriatric Medicine – Baystate; Cardiology – Baystate; Interventional Cardiology – Baystate
More info

Current Research Activities & Interests

Dr. Ashraf is an interventional cardiologist at Truman Medical Center (TMC) as well as an assistant professor of medicine at the UMKC School of Medicine. He practices cardiovascular medicine, interventional cardiology and peripheral endovascular intervention. Board certified by the American Board of Internal Medicine in internal medicine, cardiology, interventional cardiology, vascular medicine and endovascular, he is also board certified in cardiology nuclear medicine. Dr. Ashraf’s research interests include PVD and peripheral vascular intervention and atherosclerosis, obesity and ethnic variations. He has presented numerous abstracts at regional and national internal medicine and cardiovascular meetings and is involved in a number of clinical trials.

Dr. Ashraf received his medical degree from Punjab Medical College/Punjab University, Pakistan. He did his postgraduate medicine training (MRCP) at Royal College of Physician London, UK, and Royal College of Physicians Dublin, Ireland. He went on to complete an internal medicine residency at Tufts University in the Baystate Medical Centre in Massachusetts. From July 2005 to June 2009, Dr. Ashraf completed a fellowship in cardiology followed by a fellowship in interventional cardiology, both at Tufts. He also received a Master in Public Health (MPH) from the University of Massachusetts in 2008. He joined the UMKC School of Medicine and TMC in 2009.

Selected Publications

Use of Fraction Flow Reserve to Predict Changes over Time in Management of
Superficial Femoral Artery. Lotfi AS, Sivalingam SK, Giugliano GR, Ashraf J. J Interv Cardiol. 2011 Nov 17.

Michael B. Rothberg, MD, MPH; Senthil K. Sivalingam, MD; Javed Ashraf, MD, et al. Patients’ and Cardiologists’ Perceptions of the Benefits of Percutaneous Coronary Intervention for Stable Coronary Disease. Ann Intern Med. Sept.7, 2010 153:307-313.

Ethnic differences in the self-recognition of obesity and obesity-related comorbidities: a cross-sectional analysis. Sivalingam SK, Ashraf J, Vallurupalli N, Friderici J, Cook J, Rothberg MB. J Gen Intern Med. 2011 Jun;26(6):616-20.

Ashraf MJ, Cook JR, Rothberg MB. Clinical Utility of Routine Folic Acid Testing for Anemia and Dementia. J Gen Intern Med. 2008 Jun;23(6):824-6

M. Javed Ashraf. Effect of Premedication on Cognitive status of Elderly Patients Undergoing Cardiac Catheterization. (Manuscript submitted to AHJ)

M. Javed Ashraf, Sandra Bellantonio. Diastolic Heart Failure and its Management in Elderly Family Practice Recertification. June 2005; 27:53

Co-author chapter “Treatment and Prevention of Influenza” in “Manual of
Clinical Problems in Infectious Diseases”. 5th edition 2005.

Clinical Focus Articles in Irish Medical News (IMN) Paper
a) M. J. Ashraf. Diastolic Heart Failure & Management. IMN; Sept.03
b) M. J. Ashraf, John Barton. Cardiac Rehabilitation – an important step in the
management cardiac patients. Irish Medical News; Jan 21, 2002
c) M. J. Ashraf, John Barton. Peri operative Acute Myocardial Ischemia
in patients with known CAD. Irish Medical News; Feb 18, 2002

Ahmed Awad, D.O.
  • Specialty: Nephrology
Paramdeep Baqweja, M.D.
  • Specialty: Cardiovascular Disease
  • Medical School: University College of Medical Sciences, Delhi, India
  • Residency: Internal Medicine, State University of New York/Downstate Medical Center
  • Fellowships: Cardiology – State University of New York; Interventional Cardiology – State University of New York
Photo of David Bamberger, M.D.
David Bamberger, M.D.

Professor of Medicine, UMKC School of Medicine
Vice-chairman, Educational Affairs, UMKC School of Medicine
Section Chief, Infectious Diseases, UMKC School of Medicine
Medical Director, Kansas City Health Department STD Clinic
Medical Director, Occupational Health, TMC

  • Specialty: Infectious Diseases
  • Bachelor of Arts: University of Kansas
  • Medical School: Baylor College of Medicine
  • Internal Medicine Residency: University of Minnesota
  • Infectious Diseases Fellowship: University of Minnesota
Photo of Julie Banderas, Pharm.D.
Julie Banderas, Pharm.D.
Interim Chair, Department of Biomedical & Health Informatics Professor & Associate Dean for Graduate StudiesUMKC School of Medicine Work Phone: (816) 235-5249
  • Specialty: Clinical Pharmacology
  • Doctorate of Pharmacy: University of Nebraska Medical Center
  • Clinical Pharmacy Residency: Denver Veterans Affairs Medical Center
  • Pharmacotherapy Fellowship: University of Missouri-Kansas City
  • Research interests: HIV prevention, adherence to medications, engagement in care, health literacy.

View Bio

Julie earned her Doctor of Pharmacy from the University of Nebraska Medical Center in 1990. She completed a clinical pharmacy residency and pharmacotherapy fellowship before she began teaching basic and clinical pharmacology at UMKC School of Medicine in 1994. Happily, she has been able to experience a variety of rewarding opportunities at UMKC. In addition to teaching, she has engaged in clinical research in the areas of adherence, HIV treatment and prevention. She has served on the UMKC Adult Health Sciences IRB and teaches the Responsible Conduct of Research course for UMKC graduate programs. At the School of Medicine, she is the Assistant Dean for Graduate Studies and is a member of the Department of Medicine and the Department of Biomedical and Health Informatics. She enjoys the inter-professional aspects of her work.

Robert Belt, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Kansas
Abid Bhat, M.D.
  • Specialty: Pulmonary/Critical Care
  • Medical School: Government Medical College, Kashmir, India
  • Residency: Sisters Hospital, Buffalo, NY
  • Fellowship: Sleep and Pulmonary/Critical Care State University of New York at Buffalo
Joseph H. Brewer, M.D.

Clinical Assistant Professor of Medicine, UMKC School of Medicine
Medical Director of Infection Control & Hospital Epidemiology, Saint Luke’s Hospital

  • Specialty: Infectious Disease
  • Internal Medicine Residency: Saint Luke’s Hospital, Kansas City, MO
  • ID Fellowship: Emory University, Atlanta, GA
Photo of Richard Butin, M.D.
Richard Butin, M.D.
Associate Professor – UMKC Truman Medical Center Hospital HillDepartment of Internal Medicine
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Kansas
  • Medical School: University of Kansas
  • Internal Medicine Residency: Cleveland Clinic Foundation and Hospital
Photo of Donald Campbell, M.D.
Donald Campbell, M.D.
Core Faculty Professor of MedicineMissouri Endowed Chair in Internal Medicine

Joined UMKC Faculty in 1999

  • Medical School: University of Virginia School of Medicine
  • Residency: Internal Medicine, University of Kansas
  • Fellowship: Gastroenterology, University of Florida College of Medicine
Stuart Chen, M.D.
Clinical Associate Professor of Medicine Truman Medical Centers
  • Specialty: Gastroenterology
  • Medical School: Taiwan National University
  • Internal Medicine Residency: University of Minnesota
  • Doctorate of Philosophy: University of Minnesota
  • Gastroenterology Fellowship: University of Minnesota
Photo of Wendell Clarkston, M.D.
Wendell Clarkston, M.D.
GI Fellowship Program Director, Professor of Medicine Saint Luke’s Hospital
  • Specialty: Gastroenterology
  • Medical School: University of Missouri-Kansas City
  • Residency: Internal Medicine/Pediatrics University of Missouri-Kansas City
  • Fellowship: Gastroenterology, University of Missouri-Kansas City
Photo of C Douglas Cochran, M.D.
C Douglas Cochran, M.D.
Associate Program Director Assistant Professor of MedicineVice Chair, Department of Internal Medicine, St. Luke’s Hospital

Joined UMKC Faculty in 1997

  • Medical School: UMKC School of Medicine
  • Residency: Internal Medicine, UMKC School of Medicine
  • Medical Interests: thromboembolism in PICC patients, handheld decision support software, health services research
Photo of Paul Cuddy, Pharm.D., M.B.A.
Paul Cuddy, Pharm.D., M.B.A.
Senior Associate Dean of Academic Affairs, Professor Internal Medicine Work Phone: (816) 235-1809
  • Specialty: Clinical Pharmacology
  • Bachelor of Science: Massachusetts College of Pharmacy
  • Masters of Business Administration: University of Missouri-Kansas City
  • Doctorate of Pharmacy: University of Missouri-Kansas City
Photo of Diana Dark, M.D.
Diana Dark, M.D.
Associate Dean, Professor Saint Luke’s HospitalInternal Medicine
  • Specialty: Pulmonary
  • Medical School: University of Missouri-Kansas City
  • Residency: University of Kansas
  • Fellowship: University of Kansas
Tarek Darwish, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Damascas, Syria
  • Residency: Internal Medicine, University of Missouri – Kansas City
Carl Dirks, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Missouri Kansas City
  • Internal Medicine Residency: UMKC Internal Medicine Residency
  • Chief Resident: UMKC Internal Medicine Residency
Photo of Amr Edrees, M.D.
Amr Edrees, M.D.
  • Specialty: Rheumatology
  • Medical School: Cairo University, Egypt
  • Residency: Internal Medicine, University of Missouri – Kansas City
  • Fellowship: Rheumatology – University of Iowa
Photo of Alan Forker, M.D.
Alan Forker, M.D.
  • Specialty: Cardiology
  • Medical School: University of Kansas
  • Internal Medicine Residency: Mayo Clinic and Foundations
  • Cardiology Fellowship: Mayo Clinic and Foundations
More info

Professor of Medicine, UMKC School of Medicine, 1990-present Chief of Cardiology, Truman Medical Center, 1990-2000 Program Director, CV Training Program, UMKC/MidAmerica Heart Inst, 1990-2008

Still an active teacher for students, residents, fellows, and practicing physicians Director, Outpatient Lipid Diabetes Research, MidAmerica Heart Inst, 2007-present Chair, IRB, Saint Lukes Hospital, 2006-present Current Governor, MO Chapter, American College of Physicians, 2011-2015, Executive Committee — national ACP

Photo of John Foxworth, Pharm.D.
John Foxworth, Pharm.D.
Work Phone: (816) 235-1925

Associate Program Director
Director of Research
Professor of Medicine
Assistant Dean for Faculty Development
Chair, Continuing Medical Education, Truman Medical Center and UMKC School of Medicine
Faculty Officer, AOA Chapter, UMKC Medical School

Joined UMKC Faculty since 1975

  • University: UMKC for BS Pharmacy and Doctor of Pharmacy
  • Residency: Kansas City General Hospital
  • Medical Interests: teaching research methodology, biostatistics & evidence-based medicine to others

View CV

Gary Gaddis, M.D., Ph.D.
  • Specialty: Emergency Medicine
  • Medical School: Indiana University School of Medicine, Indianapolis, IN
  • Residency: Wright State University Integrated Residency in Emergency Medicine, Dayton, OH
  • PhD: Physiology, Indiana University, Bloomington IN
Photo of Ashraf Gohar, M.D.
Ashraf Gohar, M.D.
Core Faculty Associate Professor of Medicine

Joined UMKC program in 2008

  • Medical School: Cairo University School of Medicine
  • Residency:  Internal Medicine, UMKC School of Medicine
  • Fellowship: Pulmonary/Critical Care/Sleep Medicine, University of Minnesota
  • Medical Interests: Sleep medicine, residents working hours and sleep deprivation
Darcy Green-Conaway, M.D.
  • Specialty: Cardiovascular Disease
  • Medical School: University of Kansas
  • Residency: University of Kansas
  • Fellowship: Cardiology – University of Missouri – Kansas City
Photo of David Hermanns, M.D., M.P.H.
David Hermanns, M.D., M.P.H.
  • Specialty: Internal Medicine
  • Medical School: Baylor College of Medicine
  • Internal Medicine Residency: New England Medical Center
  • General Medicine Fellowship: Boston University
  • Masters of Public Health: Boston University
Peter S. Holt, M.D.
  • Specialty: Internal Medicine and Geriatrics
  • Medical School: University of Kansas Medical School
  • Internal Medicine Residency: Saint Luke’s Hospital, Kansas City, MO
  • Fellowship: Geriatrics, Stanford University
Photo of William Jennings, M.D.
William Jennings, M.D.
  • Specialty: Hematology/Oncology
  • Medical School: University of Kansas Medical School
  • Internal Medicine Residency: Mayo Graduate School of Medicine
  • Hematology Fellowship: Mayo Graduate School of Medicine
Paul Jost, M.D.

Clinical Assistant Professor of Medicine, UMKC School of Medicine

  • Specialty: Infectious Diseases
  • Medical School: University of Kansas School of Medicine
  • Internal Medicine Residency: Saint Luke’s Hospital, Kansas City, MO
  • ID Fellowship: University of Kansas
Photo of Jared Keeler, M.D.
Jared Keeler, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
Photo of Kathy Kinder, M.D.
Kathy Kinder, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Kansas
  • Residency: Internal Medicine, St.Lukes Hospital, Kansas City, MO
Photo of Richard Lustig, D.O., M.B.A.
Richard Lustig, D.O., M.B.A.
Core Faculty Assistant Professor

Joined UMKC Faculty in 2001

  • Medical School: University of Health Sciences, Kansas City, MO (KCUMB)
  • Residency: Internal Medicine, UMKC School of Medicine
  • Medical Interests: diabetes, the business of medicine
Photo of Anthony Magalski, M.D.
Anthony Magalski, M.D.
  • Specialty: CV Disease
  • Medical School: Washington University, St. Louis
Photo of Amgad Masoud, M.D.
Amgad Masoud, M.D.
  • Specialty: Internal Medicine
  • Medical School: Cairo University, Egypt
  • Residency: Internal Medicine, University of Missouri – Kansas City
Photo of Jennifer McBride, M.D.
Jennifer McBride, M.D.
Core Faculty Assistant Professor of Medicine

Joined UMKC Faculty in 2008

  • Medical School: UMKC School of Medicine
  • Residency: UMKC MedPeds
  • Medical Interests: Adolescent medicine, faculty development & patient education, Hereditary Hemorrhagic Telangiectasia
Jim Mertz, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Kansas
Photo of Jill Moormeier, M.D., M.P.H.
Jill Moormeier, M.D., M.P.H.
Chair, Department of Internal Medicine Professor of Medicine

Joined UMKC Faculty in 1990

  • Medical School: University of Nebraska
  • Residency: Internal Medicine, Columbia Presbyterian Medical Center – New York
  • Fellowship: Hematology/Oncology, University of Chicago Medical Center
  • Masters of Public Health: St. Louis Unversity
  • Medical Interests: assessment, program administration
Chris Perryman, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Kansas
  • Internal Medicine Residency: Saint Luke’s Hospital, Kansas City , MO
Photo of Dennis Pyszczynski, M.D., F.C.C.P.
Dennis Pyszczynski, M.D., F.C.C.P.
  • Specialty: Pulmonary
  • Bachelor of Arts: State University of New York
  • Medical School: State University of New York
  • Internal Medicine Residency: Millard Fillmore Hospital -Buffalo, New York
  • Pulmonary Disease Fellowship: State University of New York at Buffalo
Photo of Annette Quick, M.D.
Annette Quick, M.D.
  • Specialty: Cardiology
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
  • Cardiology Fellowship: University of Missouri-Kansas City
Photo of Brenda Rogers, M.D.
Brenda Rogers, M.D.
Core Faculty Associate Dean of Student AffairsAssociate Professor of Internal Medicine and Pediatrics

Joined UMKC faculty in 2000

  • Medical School: UMKC School of Medicine
  • Residency: UMKC MedPeds
  • Medical Interests: Medical Education Professionalism in medical education Bioethics
Photo of Esmat Sadeddin, M.D.
Esmat Sadeddin, M.D.
Section Chief of Gastroenterology, Assistant Professor of Medicine Truman Medical Center CampusTherapeutic Endoscopy
  • Specialty: Gastroenterology
  • Medical School: University of Jordan, Amman, Jordan
  • Residency: Internal Medicine, University of Missouri – Kansas City
  • Fellowship: Gastroenterology UMKC; Therapeutic Endoscopy – Washington University
Nitin Sajnani, M.D.
  • Specialty: Internal Medicine
  • Medical School: Internal Medicine, University of Missouri – Kansas City
Gaston Saliou-Diallo, M.D., F.R.C.P., F.A.C.P.
Clinical Associate Professor of Medicine Truman Medical Centers
  • Specialty: Gastroenterology
  • Medical School: University of Lausanne, Switzerland
  • Internal Medicine Residency: Hotel-Dieu Hospital, Canada
  • Nephrology Fellowship: Hotel-Dieu Hospital, Canada
  • Gastroenterology Fellowship: Hotel-Dieu Hospital, Canada
  • Gastroenterology Fellowship: University Hospital San Juan, Puerto Rico
Photo of Alan Salkind, M.D.
Alan Salkind, M.D.

Professor of Medicine, UMKC School of Medicine
Program Director, Infectious Diseases Fellowship, UMKC School of Medicine
Medical Director, Antimicrobial Stewardship Program, Truman Medical Center
Medical Director, Care Continuity, Truman Medical Center

  • Specialty: Infectious Diseases
  • Bachelor of Arts: California State University
  • Medical School: East Tennessee State University
  • Medicine Residency: Albany Medical Center Hospital
  • Infectious Diseases Fellowship: University of Rochester
Photo of Gary Salzman, M.D.
Gary Salzman, M.D.
Professor of Medicine
  • Specialty: Pulmonary
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: Wake Forest University
  • Pulmonary Fellowship: University of Missouri-Kansas City
More info
Research Interests

In 1999 UMKC School of Medicine led by Gary A. Salzman MD, FCCP in partnership with Truman Medical Center and Children’s Mercy Hospital established the UMKC Asthma Clinical Research Center (ACRC) funded by a $500,000 grant over five years from the American Lung Association (ALA). In 2004 UMKC was awarded increased funding from the American Lung Association of $750,000 over 5 years.  Recently funding was extended for another 3 years until 2012.  The American Lung Association- Asthma Clinical Research Centers (ALA-ACRC) has successfully completed five clinical trials with several additional trials under way or in preparation. Currently there are 17 clinical centers and a data coordinating center at Johns Hopkins University.

Why did the ALA fund this large network? Health care providers caring for patients with asthma need answers quickly to provide the best care for their patients. Clinical studies performed at one center or even three or four centers may take up to five years to enroll enough subjects to answer such important questions.

The ALA recognized that 17 clinical centers will be able to enroll a large number of subjects in a relatively short period of time so the studies’ results can be published and health care providers can have the answers they need to provide the best evidence-based care to their patients with asthma.

Another advantage of a large network of clinical centers is the ability to enroll subjects from diverse populations. The populations represented in the ALA-ACRC studies include the same type of patients encountered by health care providers across the country.
Five practical and clinically important questions addressed by the ALA-ACRC are summarized below.

Vaccine safety

Is the influenza vaccine safe for patients with asthma?
The ALA-ACRC Network’s first endeavor was the Study of Inactivated Influenza Vaccine in Asthmatics (SIIVA). Influenza causes substantial morbidity in adults and children with asthma. However, the rate of vaccination for patients with asthma has been low partly due to fears of increased exacerbations from the vaccine.

The purpose of SIIVA was to evaluate the safety of the influenza vaccine in patients with asthma. The trial enrolled 2,032 participants in a three-month period between September and November 2000. Results showed rates of asthma exacerbations between vaccine and placebo injections were equivalent in a diverse population of adults and children with asthma, including severe asthma.  The results were published in the New England Journal of Medicine.

Health care providers should encourage patients with asthma to be immunized. Not only is the vaccine safe in this population, but vaccination also reduces the morbidity and mortality associated with influenza in patients with asthma.

Add-on controller medications

Which add-on controller medications work well for patients with uncontrolled asthma?
The ALA-ACRC Network’s second clinical trial was the Effectiveness of Low Dose Theophylline as Add-On Therapy in Treatment of Asthma (LODO).  Current guidelines recommend adding a controller medication to the treatment regimen of poorly controlled patients with asthma. Theophylline, a relatively inexpensive asthma medication, and anti-leukotriene agents such as montelukast, are convenient choices because both are once-a-day medications taken by mouth.
The comparative effectiveness of these two add-on treatments for poorly controlled asthma is unknown. LODO is the first clinical trial to directly compare theophylline to both active (montelukast) and placebo control.

The study enrolled 489 adolescents and adults with poorly controlled asthma over an 11-month period between 2001 and 2002.  The primary outcome was the rate of episodes of poor asthma control (EPACs). An EPAC is a composite measure of asthma control including measures of asthma control, need for medical care, and lung function.

Results showed neither low-dose theophylline nor montelukast decreased the rate of EPACs in patients with poorly controlled asthma as compared to the placebo group.  Both treatments did, however, improve lung function as measured by spirometry.

In a sub-group of patients not taking inhaled corticosteroids (ICS), monotherapy low-dose theophylline resulted in both statistically and clinically significant improvements in asthma control and symptoms. Montelukast was less effective in patients not on an ICS. As such, low-dose theophylline may provide an effective, safe and low-cost treatment alternative for patients with poorly controlled asthma who can’t or won’t use ICS because of side effects, preference, or cost.

Step-down therapy

Which step-down therapy options work well for patients with mild asthma?

Current guidelines for the treatment of patients with mild persistent asthma are to establish control of symptoms using inhaled corticosteroids and then “step-down” therapy to the minimum needed to maintain control. Although step-down therapy has been studied in patients with moderate to severe asthma, it hasn’t been systematically evaluated in patients with mild asthma. This was the purpose of the Leukotriene Modifier or Corticosteroids or Corticosteroid-Salmeterol (LOCCS) trial.

A large number of patients with asthma have a mild form of the disease. Encouraging patient adherence to asthma treatment regimens continues to present challenges. Providing patients with convenient, efficacious alternative treatments associated with fewer side effects could enhance adherence and reduce unnecessary medication exposure.

This clinical trial compared three alternative treatments for patients whose asthma was well controlled on low-dose inhaled corticosteroids. The treatment groups were fluticasone (100 mg twice a day), fluticasone plus salmeterol (100/50 mg once daily) or montelukast (10 mg or 5 mg daily for adults and children, respectively). The study randomized 500 children and adults; participant follow-up was completed in July 2005.

Results showed patients with asthma well controlled on twice-daily inhaled fluticasone can be stepped-down to once daily fluticasone/salmeterol without increased rates of treatment failure.

Stepping-down to montelukast resulted in an increase in treatment failures and decreased asthma control. Notably, however, there were a high number of symptom-free days for patients in all treatment groups, including 79 percent of days for patients taking montelukast over a four-month follow-up period.  Hence, oral montelukast isn’t as effective as either low-dose ICS (twice a day) or a low-dose ICS with salmeterol (once daily), but montelukast still provided good asthma control for most patients. The results were published in the New England Journal of Medicine.

Patient education

Are the effects of patient education real or not?

The Trial of Asthma Patient Education (TAPE) was designed to evaluate the effect of patient education on the treatment response to both placebo and montelukast. The National Heart Lung Blood Institute-funded trial completed enrollment in 2005, eight months ahead of schedule.

Patients randomized to montelukast or placebo was randomized again to receive either an enhanced presentation of the study treatment or a neutral presentation. The enhanced presentation was designed to increase expectancy of therapeutic benefit.

We compared effects of the enhanced presentation independently in the montelukast and placebo groups. This comparison addressed the question — does increasing expectancy improve outcomes equally in active treatment and placebo groups?

The usual care group was compared to the placebo group receiving the neutral presentation to estimate the placebo effect. Results showed the placebo and education effects were small for measures of lung function. However, there were effects on symptom indices such as Asthma Control Score.

Furthermore, “nocebo” effects were observed on side effects, such that more patients reported headache in the placebo group after receiving information about possible side effects than those on placebo who didn’t receive similar information. These results address the specific question about the best ways to evaluate new therapies for asthma and, more generally, how the use of placebo may affect the results of clinical trials.

The main results of the trial are currently being prepared for publication as well as results from several sub-studies evaluating adherence and education effects.

GERD & asthma

Can treatment with a proton pump inhibitor (PPI) of gastroesophogeal reflux disease improve asthma control?

GERD is common in patients with asthma, even in patients who have no symptoms of heartburn. It’s predicted that GERD may contribute to poor control of asthma but its unknown if empiric treatment of GERD in patients with poorly controlled asthma can improve control.

Two complementary clinical trials funded by the NHLBI in adults and children were  conducted by the ALA-ACRC. Both trials examine whether treatment with a PPI for GERD will improve asthma control in patients with poorly controlled asthma despite relatively high doses of inhaled steroids. Subjects undergo esophageal pH monitoring for the accurate diagnosis of GERD and have methacholine challenge testing to determine changes in bronchial reactivity. The adult study was completed in 2009 and demonstrated no improvement in asthma control with high dose proton pump inhibitor treatments. The results were published in the New England Journal of Medicine.  The pediatric study will be completed in 2011.

The ALA-ACRC has provided answers to important clinical questions for health care providers working in the trenches caring for asthma patients every day. Investigators on the ALA-ACRC steering committee are planning several future studies to improve the quality of life for adults and children living with asthma.  We recently have acquired funding from the NIH for two additional studies.  One study evaluates the administration of Soy supplements to uncontrolled asthmatics to determine if there is improved asthma control.  The other study evaluates the treatment of allergic rhinitis/sinusitis on asthma control.

The UMKC ACRC is one 17 centers nationwide undertaking a multi-center research approach to discovering improved methods to manage asthma with the long term goal to find a cure for asthma.  UMKC joins Johns Hopkins, Duke, Washington University in St. Louis, and many other prestigious universities in the largest industry independent research consortium to ever study asthma.

UMKC Lung Research Center

The Lung Research Center at UMKC was started by Dr. Salzman in 2005 to expand on the successes in clinical asthma research to include collaboration with UMKC basic science researchers.  Areas of planned studies include metabolic bone disease related to the use of systemic corticosteroids, discovery of novel mechanisms of disease in sarcoidosis, lung injury related to fat embolism from long bone fractures, and the genetic characteristics of asthma.

The collaboration of the clinical and basic science investigators with expertise in many aspects of lung disease will lead to significant discoveries that will be taken from bench to bedside to improve the treatment for many types of lung disease.  The addition of an endowed chair in lung research will serve as a catalyst for the expansion of research activities and funding.  Building on the strong foundation of existing funding and the talent of existing faculty the UMKC Lung Research Center will obtain international prominence in the next five years.

Peer Reviewed Publications

The American Lung Association Asthma clinical Research Centers (including GA Salzman). Clinical Trial of Low-dose Theophylline and Montelukast in Patients with Poorly Controlled Asthma. AJRCCM 2007. 175:235-242

The American Lung Association Asthma Clinical Research Centers (including GA Salzman). Randomized Comparison of Strategies for Reducing Treatment in Mild Persistent Asthma. N Eng J Med 2007; 356:2027-2039

Salzman GA. Smoking Ruins, The Prevention of Lung Disease. Missouri Medicine 2007; 104 (3): 208-209.

Khan ZU, Salzman GA. Management of Sepsis: The Surviving Sepsis Guidelines for Early Therapy. Hospital Physician 2007; 55:21-30.

The American Lung Association Asthma Clinical Research Center (including GA Salzman). Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma. N Engl J Med 2009;360:1487-99.

M Das, GA Salzman. Pulmonary Alveolar Proteinosis: An Overview for Internists and Hospital Physicians. Hospital Practice 2010;38(1):277-280.

Cox LS, Faseru B, Mayo MS, Krebill R, Snow TS, Bronars CA, Nollen NL, Choi WS, Okuyemi KS, Salzman GA, Benowitz NL, Tyndale RF, Ahluwalia JS. Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials 2011, 12:22

Jallu SS, Salzman GA. A Case-Based Approach to Noninvasive Positive Pressure Ventilation. Hospital Practice 2011; 39(3):168-175.

The American Lung Association Asthma Clinical Research Center (including GA Salzman). Lansoprazole for Children with Poorly Controlled Asthma. JAMA. 2012;307(4):373-381

Saettele TM, Mohr J. Evaluation and Management of Acute Kidney Injury in the Intensive Care Unit. Missouri Medicine 2012:109(5):379-383

Research Support

The Leukotriene Modifier Or Corticosteroids Trial (The LOCS Trial):

A Comparison of Continued Low-Dose Inhaled Corticosteroids versus Leukotriene Modifier for Asthmatic Patients Well Controlled with Low Dose Inhaled Corticosteroids, Principal investigator. Funding from GlaxoSmithKline $4,633,888 total funding over 5 years to Asthma Clinical Research Centers 2001-2006 One of 19 principal investigators.

The Trial of Asthma Patient Education, Funding from National Heart, Blood and Lung Institute $2,570,617 total funding over 4 years to Asthma Clinical Research Centers 2002-2006. One of 19 principal investigators

Study of Acid Reflux in Asthma, Funding from National Heart, Blood and Lung Institute $3,800,627 total funding over 5 years to Asthma Clinical Research Centers 2004-2009. One of 19 principal investigators

Study of Acid Reflux in Childhood Asthma, Funding from National Heart, Blood and Lung Institute $2,414,841 total funding over 5 years to Asthma Clinical Research Centers 2007-2012 One of 20 principal investigators

American Lung Association: Asthma Clinical Research Center: 2009-2012 for $300,000. Principal Investigator

Missouri Hospital Association Regional Health Partnership Grant for Asthma Education and Research Programs- $100,000; 2002-2006. Principal Investigator

Blue Cross and Blue Shield of Kansas City: $49,875. Developing a culturally tailored smoking cessation program for heavily addicted Chronic Obstructive Pulmonary Disease (COPD) patients; Principal Investigator 2007-2009

American Lung Association Asthma Clinical Research Centers (ACRC)
The Study of Soy Isoflavones in Asthma (SOYA) National Heart, Blood and Lung Institute: R01 HL0088367-01A2- total funding $1.5 million- one of 18 ACRC multi-center co-investigators 2010-2013

American Lung Association Asthma Clinical Research Centers (ACRC) Study of Asthma and Nasal Steroids (STAN) National Heart, Blood and Lung Institute: U01 HL00895101-01A2- total funding $2.1
One of 18 ACRC multi-center co-investigators 2010-2013

Geldmacher Pulmonary Fibrosis Research Center 2012-2017 $400,000 Principal Investigator

Bruce Schwartz, M.D.
  • Specialty: Internal Medicine
  • Medical School: Ohio State University
Photo of Fariha Shafi, M.D.
Fariha Shafi, M.D.
Associate Professor Truman Medical CentersInternal Medicine
  • Medical School: Universidad Tecnologica De Santiago (UTESA), Dominican Republic
  • Residency: Internal Medicine, State University of New York at Buffalo
Shadrach Smith, M.D.
  • Specialty: Internal Medicine
  • Medical School: University of Kansas
  • Internal Medicine Residency: Tulsa Medical College
  • Internal Medicine Fellowship: Tulsa Medical College
Photo of Carol Stanford, M.D.
Carol Stanford, M.D.
  • Specialty: Internal Medicine
  • Bachelor of Arts: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
Photo of James Stanford, M.D.
James Stanford, M.D.

Associate Professor of Medicine, UMKC School of Medicine
Medical Director, Infection Prevention, Truman Medical Center

  • Specialty: Infectious Disease
  • Bachelor of Sciences: University of Missouri-Kansas City
  • Medical School: University of Missouri-Kansas City
  • Internal Medicine Residency: University of Missouri-Kansas City
  • Infectious Diseases Fellowship: Truman Medical Centers

 

Photo of Kazi Syed, M.D.
Kazi Syed, M.D.
  • Specialty: Neurology/Sleep
  • Medical School: Osmania Medical College, Hyderabad, India
  • Residency: Neurology – University of Missouri-Columbia
  • Fellowship: Clinical Neurophysiology – University of Missouri-Columbia
 
Photo of Omkar Vaidya, M.D.
Omkar Vaidya, M.D.
Core Faculty Clinical Assistant Professor
  • Specialty: Nephrology and Intensive Care Medicine
  • Medical School: Grant Medical College, Mumbai, Maharashtra India
  • Internal Medicine Residency: University of Missouri-Kansas City
  • Nephrology Fellowship: University of Texas Southwestern, Dallas, TX
  • Critical Care Fellowship: University of Missouri-Kansas City
More info

Joined UMKC in 2014

  • Medical Interests: Critical Care, renal transplantation, Internal Medicine. Teaching students and residents.

Photo of Dorota Walewicz, M.D.
Dorota Walewicz, M.D.
  • Specialty: Endocrine
  • Medical School: Collegium Medicum, Jagiellonski University – Krakow, Poland
  • Residency: Internal Medicine, University of Missouri – Kansas City
  • Fellowship: Endocrinolgy, Diabetes, and Metabolism – Temple University, Philadelphia, PA
Photo of Slawomir Walewicz, M.D.
Slawomir Walewicz, M.D.
  • Specialty: Internal Medicine
  • Medical School: Collegium Medicum, Jagiellonski University – Krakow, Poland
  • Residency: Internal Medicine, University of Missouri – Kansas City
Photo of Lamont G. Weide, M.D., Ph.D.
Lamont G. Weide, M.D., Ph.D.
Professor Department of Internal Medicine
  • Specialty: Endocrinology and Metabolism
  • Medical School: University of Texas, San Antonio
  • Doctoral Degree: University of Texas, Dallas
  • Postdoctoral Training: University of Texas, San Antonio
  • Internal Medicine Residency: Indiana University Medical Center
  • Endocrinology and Metabolism Fellowship: Washington University, St. Louis
Photo of Barry Wood, M.D.
Barry Wood, M.D.
  • Specialty: Nephrology
  • Medical School: University of Kansas
  • Internal Medicine Residency: University of Kansas School of Medicine, Saint Luke’s Hospital
  • Nephrology Fellowship: Scripps’s Research Foundation, Saint Luke’s Hospital
Photo of David Wooldridge, M.D.
David Wooldridge, M.D.
Program Director Associate Professor of Medicine

Joined UMKC Faculty in 1997

  • Medical School: UMKC School of Medicine
  • Residency: Internal Medicine, UMKC School of Medicine
  • Medical Interests: Medical education, clinical reasoning, bringing evidence-based medicine to the bedside
Photo of James Wooten, Pharm.D.
James Wooten, Pharm.D.
Basic Medical Science Work Phone: (816) 235-2197
  • Specialty: Clinical Pharmacology
  • Doctorate of Pharmacy: Creighton University
  • Clinical Pharmacy Residency: University of California, San Diego
View Bio
Dr. Wooten is an Associate Professor of Medicine, in the section of clinical pharmacology for the UMKC School of Medicine. Dr. Wooten’s responsibilities include teaching pharmacology to medical students, as well as students in both the Anesthesia Assistant and Physician Assistant Programs. Dr. Wooten has been a faculty member with the UMKC School of Medicine since 1998. He received his Doctor of Pharmacy degree from Creighton University in 1985 and completed a one-year clinical pharmacy residency at the University of California—San Diego (UCSD) Medical Center in 1986. Before joining UMKC, he worked as a clinical pharmacy coordinator in several hospitals in the Kansas City area and was also a faculty member for a family practice residency program. Dr. Wooten’s professional interests include all aspects of internal medicine and medication use in the elderly.